Domino Reaction of α-Acetyl-α-carbamoyl Ketene Dithioacetals with Vilsmeier Reagents:  A Novel and Efficient Synthesis of 4-Halogenated 2(1H)-Pyridinones

2007 ◽  
Vol 72 (24) ◽  
pp. 9259-9263 ◽  
Author(s):  
Li Chen ◽  
Yu-Long Zhao ◽  
Qun Liu ◽  
Cheng-Ri Piao
Keyword(s):  
Domino Reaction ◽  
Efficient Synthesis ◽  
Ketene Dithioacetals

scholarly journals Efficient synthesis of pyrazolopyridines containing a chromane backbone through domino reaction

2019 ◽  
Vol 15 ◽  
pp. 874-880
Author(s):  
Razieh Navari ◽  
Saeed Balalaie ◽  
Saber Mehrparvar ◽  
Fatemeh Darvish ◽  
Frank Rominger ◽  
...  
Keyword(s):  
Room Temperature ◽  
High Selectivity ◽  
Domino Reaction ◽  
Primary Amines ◽  
Efficient Synthesis ◽  
Atom Economy ◽  
Reaction Conditions ◽  
Efficient Approach ◽  
Three Component Reaction ◽  
High Yields

An efficient approach for the synthesis of pyrazolopyridines containing the aminochromane motif through a base-catalyzed cyclization reaction is reported. The synthesis was carried out through a three-component reaction of (arylhydrazono)methyl-4H-chromen-4-one, malononitrile, primary amines in the presence of Et3N at room temperature. However, carrying out the reaction under the same conditions without base led to a fused chromanyl-cyanopyridine. High selectivity, high atom economy, and good to high yields in addition to mild reaction conditions are the advantages of this approach.

ChemInform Abstract: Highly Efficient Synthesis of 3-Amino-/Alkylthio-cyclobut-2-en-1-ones Based on the Cyclization of Acyl Ketene Dithioacetals.

ChemInform ◽  
2011 ◽  
Vol 42 (6) ◽  
pp. no-no
Author(s):  
Yu-Long Zhao ◽  
Shao-Chun Yang ◽  
Chong-Hui Di ◽  
Xiao-Dan Han ◽  
Qun Liu
Keyword(s):  
Efficient Synthesis ◽  
Highly Efficient ◽  
Ketene Dithioacetals

Transition-Metal-Free, Intermolecular Azidoheteroarylation of Alkenes: Efficient Access to β-Azidoalkylated Quinoxalinones and Preliminary Antifungal Evaluation Against Magnaporthe grisea

Synthesis ◽  
2020 ◽  
Vol 52 (16) ◽  
pp. 2395-2409
Author(s):  
Weiwei Qin ◽  
Zhaodong Li ◽  
Yiming Du ◽  
Yue Chen ◽  
Yun-Lin Liu
Keyword(s):  
Transition Metal ◽  
Magnaporthe Grisea ◽  
Single Step ◽  
Domino Reaction ◽  
Efficient Synthesis ◽  
Metal Free ◽  
Efficient Access ◽  
First Time ◽  
Antibacterial Evaluation ◽  
Addition Pathway

An efficient, PhI(OAc)2-mediated, radical azidoheteroarylation of alkenes under transition-metal-free conditions is reported by employing TMSN3 and quinoxalin-2(1H)-ones as coupling partners. This domino reaction allows an efficient synthesis of valuable orangoazides containing quinoxalin-2(1H)-one derivatives and could be extended to phosphinyl-alkylated quinoxalin-2(1H)-one in a single step in moderate to excellent yields under mild conditions, as demonstrated by the preliminary antibacterial evaluation against Magnaporthe grisea for the first time. Mechanistic studies revealed that this transformation undergoes a cascade addition pathway controlled by a polar radical.

Reactions of Resin-Bound Triazenes with Dithianylium Tetrafluoroborates: Efficient Synthesis of α-Azo Ketene Dithioacetals and Related Hydrazones

2014 ◽  
Vol 16 (4) ◽  
pp. 1112-1115 ◽  
Author(s):  
Nicole Jung ◽  
Bettina Stanek ◽  
Simone Gräßle ◽  
Martin Nieger ◽  
Stefan Bräse
Keyword(s):  
Efficient Synthesis ◽  
Ketene Dithioacetals

scholarly journals Facile synthesis of annulated heterocyclic benzo[kl]acridine derivatives via one-pot N–H/C–H coupling

2016 ◽  
Vol 3 (11) ◽  
pp. 1520-1523 ◽  
Author(s):  
Yulian Zagranyarski ◽  
Artem Skabeev ◽  
Yingjie Ma ◽  
Klaus Müllen ◽  
Chen Li
Keyword(s):  
Domino Reaction ◽  
Efficient Synthesis ◽  
Facile Synthesis ◽  
One Pot ◽  
Acridine Derivatives

A facile and efficient synthesis of benzo[kl]acridines was developed based on a domino reaction via a combinatorial catalyst approach.

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