scholarly journals One-Step Continuous Flow Synthesis of Highly Substituted Pyrrole-3-carboxylic Acid Derivatives via in Situ Hydrolysis oftert-Butyl Esters

2010 ◽  
Vol 12 (22) ◽  
pp. 5182-5185 ◽  
Author(s):  
Ananda Herath ◽  
Nicholas D. P. Cosford
Keyword(s):  
Carboxylic Acid ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Butyl Esters ◽  
One Step

scholarly journals Nanofiltration-Enabled In Situ Solvent and Reagent Recycle for Sustainable Continuous-Flow Synthesis

ChemSusChem ◽  
2017 ◽  
Vol 10 (17) ◽  
pp. 3435-3444 ◽  
Author(s):  
Tamas Fodi ◽  
Christos Didaskalou ◽  
Jozsef Kupai ◽  
Gyorgy T. Balogh ◽  
Peter Huszthy ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis

Continuous Flow Synthesis of Terminal Epoxides from Ketones Using in Situ Generated Bromomethyl Lithium

2019 ◽  
Vol 21 (24) ◽  
pp. 10094-10098 ◽  
Author(s):  
Timo von Keutz ◽  
David Cantillo ◽  
C. Oliver Kappe
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis

Continuous-Flow Synthesis of (–)-Oseltamivir Phosphate (Tamiflu)

Synlett ◽  
2020 ◽  
Vol 31 (19) ◽  
pp. 1925-1929 ◽  
Author(s):  
Paul Watts ◽  
Cloudius R. Sagandira
Keyword(s):  
Residence Time ◽  
Continuous Flow ◽  
Shikimic Acid ◽  
Flow Process ◽  
Flow Synthesis ◽  
Continuous Flow Process ◽  
The Individual ◽  
Total Residence Time ◽  
Oseltamivir Phosphate

Herein the anti-influenza drug (–)-oseltamivir phosphate is prepared in continuous flow from ethyl shikimate with 54% overall yield over nine steps and total residence time of 3.5 min from the individual steps. Although the procedure involved intermediate isolation, the dangerous azide chemistry and intermediates involved were elegantly handled in situ. It is the first continuous-flow process for (–)-oseltamivir phosphate involving azide chemistry and (–)-shikimic acid as precursor.

scholarly journals The in situ generation and reactive quench of diazonium compounds in the synthesis of azo compounds in microreactors

2016 ◽  
Vol 12 ◽  
pp. 1987-2004 ◽  
Author(s):  
Faith M Akwi ◽  
Paul Watts
Keyword(s):  
Continuous Flow ◽  
Coupling Reaction ◽  
Azo Compounds ◽  
Coupling Reactions ◽  
Azo Coupling ◽  
Reaction Conditions ◽  
Flow Rates ◽  
Flow Synthesis ◽  
Optimum Flow

In this paper, a micro-fluidic optimized process for the continuous flow synthesis of azo compounds is presented. The continuous flow synthesis of Sudan II azo dye was used as a model reaction for the study. At found optimal azo coupling reaction temperature and pH an investigation of the optimum flow rates of the reactants for the diazotization and azo coupling reactions in Little Things Factory-MS microreactors was performed. A conversion of 98% was achieved in approximately 2.4 minutes and a small library of azo compounds was thus generated under these reaction conditions from couplers with aminated or hydroxylated aromatic systems. The scaled up synthesis of these compounds in PTFE tubing (i.d. 1.5 mm) was also investigated, where good reaction conversions ranging between 66–91% were attained.

scholarly journals In Situ Investigation of Multicomponent MOF Crystallization during Rapid Continuous Flow Synthesis

2021 ◽  
Author(s):  
Brandon He ◽  
Lauren K. Macreadie ◽  
James Gardiner ◽  
Shane G. Telfer ◽  
Matthew R. Hill
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
In Situ Investigation

scholarly journals One-Step Continuous Flow Synthesis of Antifungal WHO Essential Medicine Flucytosine Using Fluorine

2017 ◽  
Vol 21 (2) ◽  
pp. 273-276 ◽  
Author(s):  
Antal Harsanyi ◽  
Annelyse Conte ◽  
Laurent Pichon ◽  
Alain Rabion ◽  
Sandrine Grenier ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Essential Medicine ◽  
Flow Synthesis ◽  
One Step

Functional response of Fucus vesiculosus communities to tributyltin measured in an in situ continuous flow-through system

Hydrobiologia ◽  
1989 ◽  
Vol 188-189 (1) ◽  
pp. 277-283 ◽  
Author(s):  
C. Lindblad ◽  
U. Kautsky ◽  
C. André ◽  
N. Kautsky ◽  
M. Tedengren
Keyword(s):  
Functional Response ◽  
Continuous Flow ◽  
Fucus Vesiculosus ◽  
Flow Through

Continuous flow synthesis of the lamivudine precursor L-Menthyl Glyoxylate

2021 ◽  
Author(s):  
Lais S. D. Azevedo ◽  
Anderson R. Aguillon ◽  
Marcelo T. Lima ◽  
Raquel A. C. Leão ◽  
Rodrigo O. M. A. de Souza
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis
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