Characterization of the Novel Broad-Spectrum Kinase Inhibitor CTx-0294885 As an Affinity Reagent for Mass Spectrometry-Based Kinome Profiling

2013 ◽  
Vol 12 (7) ◽  
pp. 3104-3116 ◽  
Author(s):  
Luxi Zhang ◽  
Ian P. Holmes ◽  
Falko Hochgräfe ◽  
Scott R. Walker ◽  
Naveid A. Ali ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Broad Spectrum ◽  
Kinase Inhibitor ◽  
The Novel ◽  
Affinity Reagent

scholarly journals Electrospray Tandem Mass Spectrometry of 3'-azido-2',3'dideoxythymidine and of a Novel Series of 3'-azido-2',3',4'-trideoxy-4'thio-5-halogenouridines and their Respective α-Anomers

1994 ◽  
Vol 12 (2) ◽  
pp. 69-83 ◽  
Author(s):  
Joseph Banoub ◽  
Emmanuel Gentil ◽  
Bougrine Tber ◽  
Nour-Eddine Fahmi ◽  
Gino Ronco ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Structural Characterization ◽  
Electrospray Mass Spectrometry ◽  
Low Energy ◽  
Tandem Mass ◽  
The Novel ◽  
Electrospray Tandem Mass Spectrometry ◽  
Protonated Molecules

Electrospray mass spectrometry has aided the structural characterization of 3'-azido-2',3'-dideoxythymidine (AZI) and the novel series of 3'-azido-2',3',4'trideoxy-4'-thio-S-(bromo, chi oro or fluoro )uridine nucleosides and their respective α.anomers. Low energy CAD MS/MS analysis of the protonated molecules [M+H]+confmned the predicted fragmentation route for AZT and a series of related 4'-thio-S-halogenouridines. This MSIMS study also provided characteristic fingerprint patterns which permitted differentiation of anomers within the series of 3'-azido-2' ,3' ,4' -trideoxy-4' -thio-S-halogenouridine nucleosides.

Abstract 1638: Preclinical characterization of the novel TTK kinase inhibitor S81694 for the treatment of triple negative breast cancer

2015 ◽  
Author(s):  
Riccardo Colombo ◽  
Mike Burbridge ◽  
Marianne Rodriguez ◽  
Frédérique Cantero ◽  
Marina Caldarelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Kinase Inhibitor ◽  
The Novel

scholarly journals Synthesis and Characterization of a Trifunctional Photoinitiator Based on Two Commercial Photoinitiators with α-Hydroxyl Ketone Structure

Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5272
Author(s):  
Rong Zhong ◽  
Hui Hu ◽  
Yanfang Zhou
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Proton Nuclear Magnetic Resonance ◽  
Synthesis And Characterization ◽  
The Novel ◽  
Nuclear Magnetic Resonance Spectra ◽  
Magnetic Resonance Spectra ◽  
Nuclear Magnetic

A trifunctional photoinitiator based on commercial photoinitiators 2-hydroxy-2-methylpropiophenone (Irgacure1173) and 2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure2959) was synthesized by an esterization reaction. Its structure was characterized by UV-Vis spectrometry, Infrared Transformed Fourier, Proton Nuclear Magnetic Resonance Spectra, 13 Carbon Nuclear Magnetic Resonance Spectra, Mass Spectrometry, and Thermogravimetry. In addition, its photoinitiating activity was investigated. The results showed that the novel photoinitiator had good photoinitiating activity and thermal stability compared to commercial photoinitiators. The migration of the residual photoinitiator in the cured film was lower than that of 1173 and 2959.

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