Moving beyond the “LDL hypothesis”
Keyword(s):
Abstract. Summary: The term “LDL hypothesis” is frequently used to describe the association of low-density lipoprotein cholesterol (LDL-cholesterol, LDL-C) and cardiovascular (CV) events. Recent data from genetic studies prove a causal relation between serum LDL-C and CV events. These data are in agreement with mechanistic molecular studies and epidemiology. New randomised clinical trial data show that LDL-C lowering with statins and a non-statin drug, ezetimibe, reduces CV events. We therefore believe that the “LDL-hypothesis” has been proven; the term appears to be outdated and should be replaced by “LDL causality”.
2012 ◽
Vol 30
(3)
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pp. 141-144
2016 ◽
Vol 14
(2)
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pp. 36-40
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2017 ◽
Vol 176
(7-8)
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