Abstract
Background Currently, in developed countries, more and more women and men intend to delay childbearing and, later in life, seek fertility treatment. Some women undergoing infertility treatment develop negative feelings (anxiety, depression and irritation) associated with low life satisfaction. We aimed to examine the association between infertility-related factors, including regret over the delay in childbearing decision and life satisfaction, among Japanese women and men seeking fertility treatment. Methods This cross-sectional study included 253 women and 196 men referred to fertility facilities in Japan from July to December 2018. Participants completed a questionnaire on infertility-related factors, regret over the delay in childbearing decision, life satisfaction and sociodemographic characteristics. Life satisfaction was measured with Satisfaction with Life Scale, and the degree of regret over delay in childbearing decision was measured using a seven-point Likert scale. Participants were divided into two groups based on the neutral point of the Satisfaction with Life Scale (20-point score). Answers from the groups were compared using the Mann-Whitney U-test for continuous and ordinal variables and Chi-square tests for categorical variables. Logistic regression analyses were used to examine the association between infertility-related factors and life satisfaction. Results Regrets over the delay in childbearing decision were significantly higher in the low life satisfaction group than the high life satisfaction group ( p = 0.010); it was also negatively associated with life satisfaction (adjusted Odds Ratio = 0.85, 95% confidence interval = 0.74-0.97, p = 0.020). Further, life satisfaction was positively associated with previous live birth (adjusted Odds Ratio = 2.84, 95% confidence interval = 1.38-5.85, p = 0.005). Conclusions To reduce their regret over their decision-making related to childbearing, women and men seeking fertility treatment should be cared for by health professionals. Moreover, reproductive-aged women and men need to make informed decision-making about the timing of childbearing to avoid, later in life, feelings of regret over delayed decisions, mainly because not regretting such an important aspect of life is crucial to allow people to live a satisfying life.