Supplemental Material for Nocturia Reported in Nightly Sleep Diaries: Common Occurrence With Significant Implications?

2013 ◽  
2014 ◽  
Vol 33 (11) ◽  
pp. 1362-1365 ◽  
Author(s):  
Donald L. Bliwise ◽  
Leah Friedman ◽  
Beatriz Hernandez ◽  
Jamie M. Zeitzer ◽  
Clete A. Kushida ◽  
...  

Author(s):  
F. G. Zaki

Alterations of liver cell mitochondria represent pathologic phenomenon of a fundamental nature. Mitochondrial anomalies have been often described in association with cholestasis. In attempt to determine whether a given pattern of mitochondrial alteration has any correlation with the cause of cholestasis, liver biopsies were examined from 38 patients showing :a. extrahepatic cholestasis due to complete or partial extrahepatic biliary obstruction (8 cases proven at operation)b. intrahepatic cholestasis due to drugs (9 cases), viral hepatitis (6 cases) and alcoholic cirrhosis (15 cases).Mitochondria exhibiting ultrastructural changes due to aging or to the ‘wear and teart’ processes were not considered. In this study, the only profound and most prominent mitochondrial deformation was reported on basis of their common occurrence in randomly examined sections.


Author(s):  
Inga Kaija

A Latvian learner corpus “LaVA” is being built in the Institute of Mathematics and Computer Science, University of Latvia. The corpus includes texts written by beginner learners in the first two semesters of learning Latvian as a foreign language. The texts are written by hand and digitized afterwards in order to reduce the issues that could be caused by the necessity to learn not only writing itself but also using a foreign keyboard. One of the features that cannot be digitized is the new letters created by adding diacritical marks which are not used that way in the standard Latvian alphabet. Since one of the essential steps in learning to write in a language is learning the letters and diacritical marks of that language, this study aims to find instances of such newly made letters and to discuss the basic quantitative measures in order to define hypotheses and areas of interest for further research of such usage. Altogether 322 texts were searched, and 175 examples were found. The amount of examples found in 2nd semester texts was less than half the amount of examples found in the 1st semester texts, but the percentage of texts containing examples was higher than expected – more than 33 % in the 1st semester and almost 20 % in the 2nd semester. It leads to a conclusion that this is quite a common occurrence but also prone to reduction in the second semester. The corpus does not provide any data on later semesters so it cannot be predicted when such instances should become a rare, individual feature rather than a common one. The average amount of examples in a text is not high, though. Counting only the texts where at least one example was found, the average amount of examples per text is 2.136 in the 1st semester and 1.690 in the 2nd semester. Considering that the absolute lowest possible value here is 1, it should not be considered as a high value. Therefore, using diacritical marks to make new letters, while a common feature of the Latvian interlanguage, could be characterized as casual rather than systemic. However, that does not exclude the possibility of certain patterns in usage. The currently collected data already shows that there are some words – such as garšo, viņš, ļoti, četri – where examples were found in more than one author’s text. Examples of using unsuitable diacritical marks are also sometimes found next to letters for which said diacritical marks would be suitable. This should be explored more thoroughly using qualitative methods. The size of the corpus keeps growing; the expected size upon completion is 1000 texts. When it is reached, it would be useful to repeat the study and check whether the larger amount of data still confirms the same assumptions. The larger sample size would also allow for more detailed quantitative analysis discussing each letter, diacritical mark, placement of the diacritical mark, and metadata collected for the corpus, such as gender, native language and other spoken languages by the authors of the texts.


Pathogens ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 89
Author(s):  
Jiayu Li ◽  
Fuxian Yang ◽  
Ruobing Liang ◽  
Sheng Guo ◽  
Yaqiong Guo ◽  
...  

Cryptosporidiumfelis is an important cause of feline and human cryptosporidiosis. However, the transmission of this pathogen between humans and cats remains controversial, partially due to a lack of genetic characterization of isolates from cats. The present study was conducted to examine the genetic diversity of C. felis in cats in China and to assess their potential zoonotic transmission. A newly developed subtyping tool based on a sequence analysis of the 60-kDa glycoprotein (gp60) gene was employed to identify the subtypes of 30 cat-derived C. felis isolates from Guangdong and Shanghai. Altogether, 20 C. felis isolates were successfully subtyped. The results of the sequence alignment showed a high genetic diversity, with 13 novel subtypes and 2 known subtypes of the XIXa subtype family being identified. The known subtypes were previously detected in humans, while some of the subtypes formed well-supported subclusters with human-derived subtypes from other countries in a phylogenetic analysis of the gp60 sequences. The results of this study confirmed the high genetic diversity of the XIXa subtype family of C. felis. The common occurrence of this subtype family in both humans and cats suggests that there could be cross-species transmission of C. felis.


SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A255-A256
Author(s):  
Veronica Hire ◽  
Casey Thurmon ◽  
Hope Snyder ◽  
Ryan Harra ◽  
Jamie Walker ◽  
...  

Abstract Introduction Sleep modulates a number of psychological and cognitive processes, such as emotion regulation, executive control, and coping with stress. It is therefore not surprising that insufficient sleep quality or quantity are associated with greater self-reported stress levels. The COVID-19 pandemic has led to a particularly stressful and unprecedented time in history. While stress has been undoubtedly high during the past year, it’s less clear to what extent sleep has affected people’s perceived stress on a daily basis. The aim of this research was to estimate whether daily variations in sleep quality and duration were associated with general stress and/or stress related to COVID-19. Methods The study used a nationally representative sample to assess daily variations in sleep and stress for a period of two weeks during the COVID-19 pandemic. Morning assessments were conducted using online sleep diaries. These diaries were used to estimate sleep duration (in minutes) and sleep quality (subjective rating on a 5-point Likert scale). Evening assessments were also completed online and prompted participants to rate (0 to 100) their current “general” stress level, as well as their current anxiety in relation to COVID-19. Separate mixed effects models were conducted with days (Level 1) nested within participants (Level 2). Stress variables were lagged by a day to estimate the association between sleep (AM assessment) and stress (PM assessment). TST and SQ were entered as fixed effects and intercepts were allowed to vary randomly. Results 4,048 participants (Mage = 46.3 years; 78% women) were included as part of the analyses. The results supported that lower self-reported sleep quality predicted greater general stress levels (b = -1.43, p < 0.001). Lower self-reported sleep quality also predicted greater COVID-19 related anxiety (b = -0.543, p < 0.001). In contrast, sleep duration was not significantly related to general stress or COVID-19 anxiety after controlling for sleep quality. Conclusion The present data supports that daily variations in sleep quality are related to a person’s overall stress levels and COVID-19 anxiety. These findings may have implications for the role of good sleep in mitigating the increases in stress that have resulted from the COVID-19 pandemic. Support (if any) Vargas: K23HL141581


Trauma ◽  
2021 ◽  
pp. 146040862110009
Author(s):  
M Mihalik ◽  
N Allopi

Penetrating abdominal injuries, especially from gun shot wounds, are a common occurrence in South African hospitals, and a vast majority of these patient receive surgical intervention for suspected intra-abdominal injuries. Not all bullets are found and removed however, and we detail the case of a gentleman who presented to our institution with obstructive jaundice secondary to an extraluminal compression of his biliary tree by a retained migrated bullet, that spontaneously resolved, without any surgical intervention.


SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A285-A285
Author(s):  
Odalis Garcia ◽  
Danica Slavish ◽  
Jessica Dietch ◽  
Brett Messman ◽  
Ateka Contractor ◽  
...  

Abstract Introduction Nurses may experience frequent nightmares due to stressful work environments. Some studies estimate that 35% of nurses experience nightmares related to experiences at work. Nightmares may also exacerbate stress among nurses, although this has yet to be tested empirically. We examined daily bidirectional associations between stress severity and nightmare occurrence and severity, and whether posttraumatic stress disorder (PTSD) symptoms moderated those relationships. Methods 392 nurses (mean age = 39.54 years; SD = 11.15; 92% female; 78% White) were recruited for a larger study on sleep and vaccine response. For 14 days, upon awakening, nurses completed daily sleep diaries to assess previous-day stress severity (0 = not at all, 4 = extremely), as well as nightmare occurrence (0 = no nightmare, 1 = nightmare occurred) and nightmare severity (0 = not at all, 3 = very). PTSD symptoms were assessed at baseline using the PTSD Checklist of DSM-5 (PCL-5). Multilevel models were used to examine bidirectional, within-person associations between daily stress and nightmares, and cross-level moderation by baseline PTSD symptoms. Results Approximately 10.5% of nurses met criteria for PTSD based on PCL-5 scores. 47.2% of nurses reported at least one nightmare across the two weeks. Days with greater stress severity were associated with higher odds of experiencing a nightmare (OR = 1.22, p = 0.001), as well as greater nightmare severity that night (b = 0.09, p = 0.033). Nightmare occurrence (b = 0.15, p < 0.001) was associated with greater next-day stress severity. PTSD symptoms did not moderate daily stress and nightmare associations. Conclusion Nurses face intense occupational demands and frequent exposure to potentially traumatic events. Our results indicated nightmares and stress may occur in a bidirectional fashion among nurses. Results were similar regardless of nurses’ PTSD status. Future studies should explore whether targeting nightmares and stress may improve nurses’ health and well-being. Given the essential role that nurses play in maintaining patient health and safety, it is critical to understand the causes and consequences of their sleep-related disturbances. Support (if any):


2021 ◽  
pp. 074873042110060
Author(s):  
Dorothee Fischer ◽  
Till Roenneberg ◽  
Céline Vetter

The study aimed to explore chronotype-specific effects of two versus four consecutive morning or night shifts on sleep-wake behavior. Sleep debt and social jetlag (a behavioral proxy of circadian misalignment) were estimated from sleep diary data collected for 5 weeks in a within-subject field study of 30 rotating night shift workers (29.9 ± 7.3 years, 60% female). Mixed models were used to examine whether effects of shift sequence length on sleep are dependent on chronotype, testing the interaction between sequence length (two vs. four) and chronotype (determined from sleep diaries). Analyses of two versus four morning shifts showed no significant interaction effects with chronotype. In contrast, increasing the number of night shifts from two to four increased sleep debt in early chronotypes, but decreased sleep debt in late types, with no change in intermediate ones. In early types, the higher sleep debt was due to accumulated sleep loss over four night shifts. In late types, sleep duration did not increase over the course of four night shifts, so that adaptation is unlikely to explain the observed lower sleep debt. Late types instead had increased sleep debt after two night shifts, which was carried over from two preceding morning shifts in this schedule. Including naps did not change the findings. Social jetlag was unaffected by the number of consecutive night shifts. Our results suggest that consecutive night shifts should be limited in early types. For other chronotypes, working four night shifts might be a beneficial alternative to working two morning and two night shifts. Studies should record shift sequences in rotating schedules.


1996 ◽  
Vol 4 (4) ◽  
pp. 1-7
Author(s):  
Susan D Moffatt ◽  
Winston S Parkhill

Ulnar nerve compression causing clinical symptoms is a common occurrence. There are numerous conditions that can cause compression. Recently two very interesting and unusual etiologies were seen at the Plastic Surgery service. Leprosy causing ulnar nerve compression is a rare occurrence in a Canadian hospital, and so is a case of palmar mycotic aneurysm in the postantibiotic era.


Author(s):  
Danica C Slavish ◽  
Justin Asbee ◽  
Kirti Veeramachaneni ◽  
Brett A Messman ◽  
Bella Scott ◽  
...  

Abstract Background Disturbed sleep can be a cause and a consequence of elevated stress. Yet intensive longitudinal studies have revealed that sleep assessed via diaries and actigraphy is inconsistently associated with daily stress. Purpose We expanded this research by examining daily associations between sleep and stress using a threefold approach to assess sleep: sleep diaries, actigraphy, and ambulatory single-channel electroencephalography (EEG). Methods Participants were 80 adults (mean age = 32.65 years, 63% female) who completed 7 days of stressor and sleep assessments. Multilevel models were used to examine bidirectional associations between occurrence and severity of daily stress with diary-, actigraphy-, and EEG-determined sleep parameters (e.g., total sleep time [TST], sleep efficiency, and sleep onset latency, and wake after sleep onset [WASO]). Results Participants reported at least one stressor 37% of days. Days with a stressor were associated with a 14.4-min reduction in actigraphy-determined TST (β = −0.24, p = 0.030), but not with other actigraphy, diary, or EEG sleep measures. Nights with greater sleep diary-determined WASO were associated with greater next-day stressor severity (β = 0.01, p = 0.026); no other diary, actigraphy, or EEG sleep measures were associated with next-day stressor occurrence or severity. Conclusions Daily stress and sleep disturbances occurred in a bidirectional fashion, though specific results varied by sleep measurement technique and sleep parameter. Together, our results highlight that the type of sleep measurement matters for examining associations with daily stress. We urge future researchers to treat sleep diaries, actigraphy, and EEG as complementary—not redundant—sleep measurement approaches.


Sign in / Sign up

Export Citation Format

Share Document