Regulatory Genes controlling the Synthesis of Heavy Chains of Human Immunoglobulin-G

Nature ◽  
1967 ◽  
Vol 214 (5090) ◽  
pp. 783-785 ◽  
Author(s):  
NOELENE LOBB ◽  
C. C. CURTAIN ◽  
CHEV KIDSON
1967 ◽  
Vol 105 (3) ◽  
pp. 1019-1028 ◽  
Author(s):  
J. W. Prahl

The sequences of the C-terminal octadecapeptides obtained by cyanogen bromide cleavage of the γ-chains of myeloma proteins of the four subclasses, and a urinary heavy-chain-disease protein, have been determined. Although the sequences were markedly homologous, unique replacements were identified that distinguished between the γ2b, γ2c and γ2d subclasses. The data are in accord with the postulated existence of four genetic loci or cistrons, these having arisen by the process of gene duplication.


Anaerobe ◽  
2001 ◽  
Vol 7 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Daniel Grenier ◽  
Denis Mayrand

1982 ◽  
Vol 10 (2) ◽  
pp. 104-104 ◽  
Author(s):  
PETER G. H. BYFIELD ◽  
SUE COPPING ◽  
WILLIAM A. BARTLETT

1973 ◽  
Vol 10 (9) ◽  
pp. 583-589
Author(s):  
Ryuichi Yokohari ◽  
Koyo Takeda ◽  
Yukio Imamura

1987 ◽  
Vol 7 (6) ◽  
pp. 465-470 ◽  
Author(s):  
Nirmalendu Das ◽  
Mukul Kumar Basu ◽  
Manoj Kumar Das

125Iodine labelled human immunoglobulin-G encapsulated liposomes were administered orally to rats. Distribution of radioactivity was checked in various tissues and in portal blood. The effect of dextran sulfate (DS 500,000 m. wt., liver blockade agent) injection (i.p.) on the liver uptake of liposomes and on the amount of liposomes appearing in the portal blood from the gastrointestinal tract have been studied. An increased amount of radioactivity was observed in the portal blood and the amount of radioactivity in the liver decreased appreciably after injection of dextran sulfate. In both the cases the action of dextran sulfate started 2 hours after injection and reached maximum at 12 hour, falling slightly at 24 hour.


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