A blood marker predicts who gets ‘breakthrough’ COVID

Nature ◽  
2021 ◽  
Author(s):  
Smriti Mallapaty
Keyword(s):  
Blood Marker

scholarly journals AB0603 PDGFΑ AS A POTENTIAL BLOOD MARKER IN DSSC

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1598.3-1598
Author(s):  
K. Romanowska-Prochnicka ◽  
A. Wajda ◽  
A. Paradowska-Gorycka ◽  
A. Felis-Giemza ◽  
E. Walczuk ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Late Phase ◽  
Mrna Level ◽  
Method Comparison ◽  
Active Phase ◽  
Ground Glass ◽  
Skin Involvement ◽  
Blood Marker ◽  
Spearman Test ◽  
Non Parametric

Background:PDGF is a potential important factor in the pathogenesis of scleroderma. PDGF is almost undetectable in healthy skin or lung. Immunohistochemical studies have revealed increased presence of PDGFαand PDGFβreceptors in scleroderma skin biopsies.Objectives:The aim of this study was to determine the mRNA level ofIFNα1,IL-4, TGFβ1,TGFβ2,PDGFα,PDGFβ,TNFαin whole blood in SSc patients in the aspect of clinicalMethods:A group of 14 patients (50% were women) with systemic sclerosis based on EULAR / ACR 2013 criteria was included in the study. The modified Rodnan Skin Score (mRSS) was evaluated by same assistant at the beginning of the study and six months later. DLCO, HRCT, echocardiography and NFC were measured.Gene expression was determined using validated TaqMan probes in qPCR. Constitutive mRNA level of selected genes was analyzed using ΔCt method. Comparison between different groups of patients was determined using non-parametric Mann-Whitney U test. Correlation was analyzed using non-parametric Spearman test.Results:The mean age of the patients was 60 ± 15.66. 100% of patients had organ involvement as pulmonary fibrosis. 78% - had active changes -features of ground glass.64% of patients had mild mRSS-1-10 skin involvement, 36% had moderate to severe skin involvement. In SSc patientsTGFβ1andIFNα1revealed the highest level of expression in comparison to other analyzed genes. Additionally, very high and significant correlation betweenTNFαandTGFβ1(r=0.7 p=0.004) has been noted. High and significant correlation between mRNAPDGFβandTNFαlevels have been observed. We did not reveal significant differences in analyzed genes expression when compare limited and diffuse SSc. Nevertheless, patients with dSSc were characterized by higher level ofIFNα1(almost 2 times) andTGFβ1. On the border of significance higherPDGFαmRNA level was observed in dSSc patients when compared to lSSc. AveragePDGFαexpression is higher in SSc patients with Scl70 positive than than in patients without Scl70 (p=0.04).In the aspect of clinical parameters, patients with ESR ≤12 mm/h revealed almost 6 times higher level ofIFNα1(p=0.01) in comparison to the patient with ESR>12mm/h.Patients with mRSS above10 points revealed significantly higher ofPDGFαexpression in comparison to patients with mRSS ≤10 (p=0.04). In these group of patients CRP and ESR were not different significantly.In the case of patients with active fibrosis (ground glass) in HRCTIFNα1expression was almost 2.5-times higher than in patients with HRCT non-active. Significantly higherPDGFα has been revealed in patients with active HRCT when compared with patient with non-active HRCT. Nevertheless these two groups did not differ in ESR or OB parameter.SSc patients in active phase of NFC revealed almost 3 times higher level ofIFNα1expression in comparison with the patient in late phase.Conclusion:The mRNA level ofPDGFαmay be a potential blood marker to predict worse prognosis in sclerodermaReferences:[1]Rheumatology (Oxford). 2008 Oct;47 Suppl 5:v2-4. doi: 10.1093/rheumatology/ken265.Role of PDGF in fibrotic diseases and systemic sclerosis.Trojanowska M1.Acknowledgments:NoDisclosure of Interests:None declared

Efficacy of prayer in inducing immediate physiological changes: a systematic analysis of objective experiments

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Felix Chin ◽  
Ryan Chou ◽  
Muhammad Waqas ◽  
Kunal Vakharia ◽  
Hamid Rai ◽  
...  
Keyword(s):  
Physiological State ◽  
Experimental Studies ◽  
Peripheral Resistance ◽  
Pain Tolerance ◽  
Physiological Status ◽  
Physiological Changes ◽  
Mental Functioning ◽  
Baroreceptor Sensitivity ◽  
Systematic Analysis ◽  
Blood Marker

Abstract Objectives To assess the immediate impact of prayer on physiological state by systematically reviewing objective, controlled experimental studies in the literature. Content Experimental studies measuring objective physiological changes induced by prayer. Studies containing the keyword, “Prayer” anywhere in the title or abstract were curated from the following databases: Public/Publisher Medline (PubMed), Excerpta Medica Database (EMBASE) and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) in May 2019. Titles and abstracts were screened with the remaining 30 articles analyzed for inclusion. Only experimental studies were included. Summary Eight experimental studies were identified of which five investigated neurocognitive changes and three investigated systemic physiological changes during prayer. The five studies focusing on neuroactivity used functional MRI (fMRI), electroencephalography or SPECT imaging to obtain measurements. The remaining three studies analyzed an array of systemic physiological metrics, including blood pressure, heart rate, respiratory rate, peripheral resistance, baroreceptor sensitivity and/or cardiovascular rhythm variability during prayer. All studies aside from one saw objective changes during prayer. Neurocognitive changes were mainly associated with improved mental functioning, control and pain tolerance. Prayer was found to slow down physiological functions in two of the three vital-based studies, with the third reporting no change in physiological status. None of the studies measured blood marker changes. Outlook Experimental studies show prayer to induce healthy neurocognitive and physiological changes. Additional studies exploring objective measures from prayer are encouraged to provide practitioners with a more nuanced, scientific perspective when it comes to prescribing prayer as a complementary and alternative medicine (CAM) therapy.

scholarly journals The Value of Interleukin-6 among Several Inflammatory Markers as a Predictor of Respiratory Failure in COVID-19 Patients

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1327
Author(s):  
Mitsuhiro Fujino ◽  
Michiyo Ishii ◽  
Takuya Taniguchi ◽  
Hiroya Chiba ◽  
Masaki Kimata ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Interleukin 6 ◽  
Inflammatory Markers ◽  
Characteristic Curve ◽  
Respiratory Illness ◽  
Reactive Protein ◽  
Short Period ◽  
Blood Marker ◽  
Fraction Of Inspired Oxygen ◽  
Reliable Marker

Patients with coronavirus disease 2019 (COVID-19) develop severe respiratory failure within a short period during the clinical course. It is essential to predict respiratory deterioration in the short term. We investigated the use of inflammatory markers to predict respiratory distress within three days from their analysis in COVID-19 patients. This retrospective observational study included 81 patients admitted with COVID-19. Patients were divided into two groups according to whether the maximum fraction of inspired oxygen (FiO2) for three days from the blood marker measurements was ≥0.4 (high FiO2 group; HFG) or <0.4 (low FiO2 group; LFG). Interleukin-6 (IL-6), C-reactive protein (CRP), lactate dehydrogenase (LDH), white blood cell, D-dimer, and creatinine levels were compared between the two groups. The levels of all markers were significantly higher in HFG patients. Areas under the receiver operating characteristic curve of IL-6, CRP, and LDH had high values of 0.85, 0.82, and 0.81, respectively. The odds ratio of IL-6 which was crude and adjusted for dexamethasone administration initiated before laboratory measurement, showed the high value of 29.1 (5.6–295.6) and 53.9 (4.5–3242.8), respectively. IL-6 can be used as a reliable marker for predicting respiratory illness within three days after assessment.

Chromogranin a Measurement in Neuroendocrine Tumors

1998 ◽  
Vol 13 (1) ◽  
pp. 3-9 ◽  
Author(s):  
L. Ferrari ◽  
E. Seregni ◽  
A. Martinetti ◽  
B Van Graafeiland ◽  
S. Nerini-Molteni ◽  
...  
Keyword(s):  
Tumor Marker ◽  
Neuroendocrine Tumors ◽  
Chromogranin A ◽  
High Sensitivity ◽  
Biologically Active ◽  
Proliferative Index ◽  
Favorable Prognosis ◽  
Blood Marker ◽  
Active Substances

Neuroendocrine tumors (NETs) are rare neoplasms characterized by a low proliferative index and, in some cases, a favorable prognosis. These tumors often overproduce and release biologically active substances that are responsible for severe syndromes. Tumor marker measurement provides the clinician with useful information for the management of NET patients. The substances released by overproducing tumors are currently used as biomarkers, but there is a need for sensitive markers also for the “biochemically silent” NETs. The most effective and reliable blood marker available today is chromogranin A (CgA). Because of its high sensitivity and specificity, this glycoprotein can be used for the diagnosis, prognosis and follow-up of NETs. Furthermore, CgA measurement can be used for monitoring those tumors not overproducing or releasing any hormones or biological amines. This paper is a synthetic review on the value of CgA in NET management and reports our experiences with CgA measurement in NET patients.

Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury

Biomarkers ◽  
2014 ◽  
Vol 19 (7) ◽  
pp. 578-584 ◽  
Author(s):  
Huailei Ma ◽  
Jing Ning ◽  
Xin Jin ◽  
Chunming Mao ◽  
Xiangli Bu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Blood Marker ◽  
Betaine Homocysteine Methyltransferase ◽  
Homocysteine Methyltransferase

scholarly journals Association between blood marker analyses regarding physical fitness levels in Spanish older adults: A cross-sectional study from the PHYSMED project

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0206307 ◽  
Author(s):  
Raquel Aparicio-Ugarriza ◽  
Ángel Enrique Díaz ◽  
Gonzalo Palacios ◽  
María del Mar Bibiloni ◽  
Alicia Julibert ◽  
...  
Keyword(s):  
Older Adults ◽  
Physical Fitness ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Blood Marker ◽  
Fitness Levels

scholarly journals Musculoskeletal Outcomes from Chronic High-Speed, High-Impulse Resistance Exercise

2018 ◽  
Vol 39 (10) ◽  
pp. 791-801 ◽  
Author(s):  
John Caruso ◽  
Michael Voor ◽  
Jason Jaggers ◽  
T. Symons ◽  
Jeremy Stith ◽  
...  
Keyword(s):  
Mechanical Loading ◽  
High Speed ◽  
Type I Collagen ◽  
Training Session ◽  
Knee Extension ◽  
Type I ◽  
Before And After ◽  
Force Peak ◽  
Blood Marker ◽  
Hip Extension

AbstractWhile bones and muscles adapt to mechanical loading, it appears that very specific types of stimuli must be applied to achieve osteogenesis. Our study assessed musculoskeletal outcomes to 30 training sessions on an Inertial Exercise Trainer (Newnan, GA). Subjects (n=13) performed workouts with their left leg, while their right served as an untreated control. Workouts entailed three 60-s sets each of knee extension, hip extension and calf press exercises, separated by 90-s rests. Before and after the 30 training sessions, subjects underwent strength tests (knee and ankle extensors of both legs), DEXA scans (hip, knee and ankles of both legs), and blood draws. After 30 training sessions 2×2 ANOVAs showed left leg peak torques rose significantly. 2×2 ANCOVAs, with bone scan area as a covariate, showed significant left leg calcaneal bone mineral content (+29%) and density (+33%) increases after 30 training sessions. A significant decline in C-terminal telopeptides of type I collagen, a blood marker of bone resorption, also occurred after 30 training sessions. The Inertial Exercise Trainer’s large volume of training session repetitions elicited high peak force, peak acceleration and impulses that likely provided a mechanical loading stimulus that evoked calcaneal accretion.

scholarly journals Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis

EBioMedicine ◽  
2022 ◽  
Vol 75 ◽  
pp. 103797
Author(s):  
Neus Martínez-Bosch ◽  
Helena Cristóbal ◽  
Mar Iglesias ◽  
Meritxell Gironella ◽  
Luis Barranco ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Chronic Pancreatitis ◽  
Early Detection ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Blood Marker

Chronic alcohol consumption changes blood marker profile and bone density in rats with apical periodontitis

2019 ◽  
Vol 10 (3) ◽  
Author(s):  
Renan Dal‐Fabbro ◽  
Melyna Marques de Almeida ◽  
Leopoldo Cosme‐Silva ◽  
Antonio H. C. Neto ◽  
Leda M. P. Salzedas ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Bone Density ◽  
Apical Periodontitis ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption ◽  
Blood Marker ◽  
Marker Profile

scholarly journals Quantitative mass spectrometry suggests beta‐synuclein as promising blood marker for synaptic degeneration in Alzheimer's disease

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Patrick Oeckl ◽  
Steffen Halbgebauer ◽  
Sarah Straub ◽  
Christine von Arnim ◽  
Janine Diehl‐Schmid ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Quantitative Mass Spectrometry ◽  
Synaptic Degeneration ◽  
Blood Marker
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