Mutation linked to type of pancreatic tumour

2014 ◽  
Author(s):  
Sedeer El-Showk
Keyword(s):  
Pancreatic Tumour

Predictive value of CA 19-9 in patients with pancreatic tumours

2020 ◽  
Vol 14 (1) ◽  
pp. 45-48
Author(s):  
Faiza Abrar ◽  
Adnan Riaz ◽  
Kaukab Sultana ◽  
Tariq Feroz Khawaja
Keyword(s):  
Surgical Resection ◽  
Predictive Value ◽  
Local Population ◽  
Pancreatic Disease ◽  
International Studies ◽  
Malignant Tumours ◽  
Pancreatic Tumours ◽  
Benign Pathology ◽  
Pancreatic Tumour ◽  
Age Range

Background: Pancreatic carcinoma is a disease with high modality and has a high incidence of recurrence after surgical resection. The prognosis depends on early diagnosis and treatment. Numerous international studies have reported use of CA 19-9 in diagnosis of pancreatic cancer. We planned this study to validate role of CA 19-9 in our local population. The objective of this study is to correlate raised serum CA 19-9 levels in patients with pancreatic tumours to distinguish between benign and malignant pancreatic disease. Subjects and methods: The present study is a validation study. Thirty-five patients with diagnosis of pancreatic tumor on radiological imaging were included after their informed consent. Data collection forms were filled, blood samples were taken and serum CA 19-9 was estimated by ELISA in Biochemistry department, SIMS. Histopathology samples were collected at time of surgical resection, sent to pathology departments of respective hospitals and histopathological reports collected. All data was collected and analysed by using descriptive method. The study was conducted in Biochemistry department of PGMI and SIMS, Lahore from May 2015 till June 2016. Results: Out of 35 patients, nineteen (54.3%) were female and sixteen (45.7%) were male. Thirty [85.7%] patients were between third to seventh decades of their life. The mean age range around 47.28. Thirty-four patients had malignant tumor and 1 benign on histopathology. CA 19-9 was raised (>37 U/ml) in 33 out of 34 patients with malignant pathology. The patient with benign pathology had CA 19-9 level <37U/ml (the cut off value). Head of pancreas was the commonest site in 32 patients (65%) for tumour occurrence. Total 28 (82%) patients had adenocarcinoma as the histological type of pancreatic tumour. Cholangiocarcinoma in Periampullary region of pancreas was second in frequency, 4 patients (12%). CA 19-9 shows sensitivity of 97% and specificity of 100% to diagnose carcinoma of pancreas in patients with pancreatic tumour. CA 19-9 has 100% positive predictive value to diagnose benign tumour and 50% negative predictive value to diagnose malignant tumours. Conclusion: Raised levels of CA 19-9 has an important role in diagnosis of patients with pancreatic tumour to differentiate between benign and malignant pathology.

scholarly journals ROS and TGFβ: from pancreatic tumour growth to metastasis

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Chao-Hui Chang ◽  
Siim Pauklin
Keyword(s):  
Tumour Growth ◽  
Cancer Metastasis ◽  
Transforming Growth Factor ◽  
Cancer Therapeutics ◽  
Transforming Growth Factor Β ◽  
Ductal Adenocarcinoma ◽  
Cellular Processes ◽  
Tumour Development ◽  
Pancreatic Tumour ◽  
Tgfβ Signalling

AbstractTransforming growth factor β (TGFβ) signalling pathway switches between anti-tumorigenic function at early stages of cancer formation and pro-tumorigenic effects at later stages promoting cancer metastasis. A similar contrasting role has been uncovered for reactive oxygen species (ROS) in pancreatic tumorigenesis. Down-regulation of ROS favours premalignant tumour development, while increasing ROS level in pancreatic ductal adenocarcinoma (PDAC) enhances metastasis. Given the functional resemblance, we propose that ROS-mediated processes converge with the spatial and temporal activation of TGFβ signalling and thereby differentially impact early tumour growth versus metastatic dissemination. TGFβ signalling and ROS could extensively orchestrate cellular processes and this concerted function can be utilized by cancer cells to facilitate their malignancy. In this article, we revisit the interplay of canonical and non-canonical TGFβ signalling with ROS throughout pancreatic tumorigenesis and metastasis. We also discuss recent insight that helps to understand their conflicting effects on different stages of tumour development. These considerations open new strategies in cancer therapeutics.

scholarly journals Eosinophilic Pancreatitis Mimicking Pancreatic Neoplasia

2006 ◽  
Vol 20 (5) ◽  
pp. 361-364 ◽  
Author(s):  
Ali Cay ◽  
Mustafa Imamoglu ◽  
Umit Cobanoglu
Keyword(s):  
Immunoglobulin E ◽  
Hypereosinophilic Syndrome ◽  
Clinical Manifestations ◽  
Oral Prednisolone ◽  
Pancreatic Mass ◽  
Eosinophilic Infiltration ◽  
Oral Steroid ◽  
Surgical Biopsy ◽  
Pancreatic Tumour ◽  
Oral Steroid Therapy

Eosinophilic pancreatitis (EP) is a rare disease. It typically occurs in the setting of either eosinophilic gastroenteritis or the hypereosinophilic syndrome. Isolated eosinophilic infiltration of the pancreas is less common. EP usually presents as a pancreatic tumour with abdominal pain and/or obstructive jaundice. The diagnosis is often not made until after pancreatic resection under suspicion of a pancreatic tumour.The case of a 14-year-old boy whose initial presentation was suggestive of a pancreatic tumour is reported. Radiological evaluation revealed a pancreatic mass suggestive of a pancreatic tumour obstructing the duodenum and common bile duct. The patient underwent surgery and a gastrojejunal anostomosis, tube cholecystostomy and biopsy were performed with no postoperative complications. The diagnosis of EP was established after surgical biopsy. The biopsy specimen revealed prominent eosinophilic infiltration. Serum immunoglobulin E levels were elevated. The patient was treated with oral prednisolone (40 mg/day). After two months of oral steroid therapy, clinical manifestations rapidly improved and peripheral eosinophilia subsided. Computed tomography scan revealed remission of the pancreatic mass-like lesion.

scholarly journals PSEUDO PAPILLARY TUMOUR OF PANCREAS

2009 ◽  
Vol 16 (04) ◽  
pp. 609-610
Author(s):  
QURATULAIN SOOMRO ◽  
Hafeez Soomro ◽  
KHAN MUHAMMAD ◽  
Sardar Khatoon ◽  
ABDUL SAMAD SHAIKH ◽  
...  
Keyword(s):  
Excisional Biopsy ◽  
Malignant Potential ◽  
Definitive Treatment ◽  
Low Grade ◽  
Young Females ◽  
Invasive Tumour ◽  
Papillary Tumour ◽  
Pancreatic Tumour ◽  
Low Malignant Potential

During 05 years period from January 2003 to December 2007,45 cases of Ca. Pancreas were reported to LINAR and only onecase of Pseudo Papillary Tumour of Pancreas is registered. It is a rare, low malignant potential pancreatic tumour. It has unknown pathogenesisand found in young females. We report a case of 24 years old female, who presented with pain in abdomen and low grade fever of 07 monthsduration. Lepratomy and excisional biopsy was done. H/P came as Pseudo Papillary Tumour of Pancreas. At presentation no any L.N. werefound enlarged. Like other malignant pancreatic tumours, this neoplasm does not metastasize. Its definitive treatment is complete surgicalremoval, no any role of chemotherapy because it doesn't metastasized, limited role of radiotherapy in local invasive tumour or in residual mass.

scholarly journals Peritoneal Patch Used for Vascular Reconstruction of the Superior Mesenteric Vein Invaded by Locally Advanced Pancreatic Tumour

2017 ◽  
Vol 22 (3) ◽  
pp. 132
Author(s):  
Mehmet Tahir Oruc; ◽  
Tuğrul Cakır ◽  
Arif Aslaner ◽  
Erdem Can Yardımcı ◽  
Alkan Sakar
Keyword(s):  
Superior Mesenteric Vein ◽  
Locally Advanced ◽  
Vascular Reconstruction ◽  
Mesenteric Vein ◽  
Pancreatic Tumour
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