scholarly journals Genomic reorganization in germinal centres

2016 ◽  
Vol 16 (10) ◽  
pp. 595-595
Author(s):  
Olive Leavy
Keyword(s):  
Germinal Centres ◽  
Genomic Reorganization

scholarly journals Chromosomal Analysis in Crotophaga ani (Aves, Cuculiformes) Reveals Extensive Genomic Reorganization and an Unusual Z-Autosome Robertsonian Translocation

Cells ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 4
Author(s):  
Rafael Kretschmer ◽  
Ricardo José Gunski ◽  
Analía del Valle Garnero ◽  
Thales Renato Ochotorena de Freitas ◽  
Gustavo Akira Toma ◽  
...  
Keyword(s):  
Robertsonian Translocation ◽  
Chromosome Evolution ◽  
Sex Chromosome ◽  
Rare Event ◽  
Chromosome Morphology ◽  
Z Chromosome ◽  
Molecular Cytogenetic ◽  
Intrachromosomal Rearrangements ◽  
Genomic Reorganization

Although cytogenetics studies in cuckoos (Aves, Cuculiformes) have demonstrated an interesting karyotype variation, such as variations in the chromosome morphology and diploid number, their chromosome organization and evolution, and relation with other birds are poorly understood. Hence, we combined conventional and molecular cytogenetic approaches to investigate chromosome homologies between chicken and the smooth-billed ani (Crotophaga ani). Our results demonstrate extensive chromosome reorganization in C. ani, with interchromosomal rearrangements involving macro and microchromosomes. Intrachromosomal rearrangements were observed in some macrochromosomes, including the Z chromosome. The most evolutionary notable finding was a Robertsonian translocation between the microchromosome 17 and the Z chromosome, a rare event in birds. Additionally, the simple short repeats (SSRs) tested here were preferentially accumulated in the microchromosomes and in the Z and W chromosomes, showing no relationship with the constitutive heterochromatin regions, except in the W chromosome. Taken together, our results suggest that the avian sex chromosome is more complex than previously postulated and revealed the role of microchromosomes in the avian sex chromosome evolution, especially cuckoos.

Germinal Centres in the Affinity Maturation of T Cell-Dependent Antibody Responses

1993 ◽  
pp. 21-26
Author(s):  
Ian C. M. Maclennan ◽  
Yong-Jun Liu ◽  
Deborah Hardie ◽  
Gerald D. Johnson ◽  
Montserrat Casamayor-Palleja ◽  
...  
Keyword(s):  
T Cell ◽  
Affinity Maturation ◽  
Antibody Responses ◽  
Germinal Centres

Germinal centres seen through the mathematical eye: B-cell models on the catwalk

2009 ◽  
Vol 30 (4) ◽  
pp. 157-164 ◽  
Author(s):  
Michael Meyer-Hermann ◽  
Marc Thilo Figge ◽  
Kai-Michael Toellner
Keyword(s):  
B Cell ◽  
Cell Models ◽  
Germinal Centres

Development of the lymphoid tissues of the tammar wallaby Macropus eugenii

1997 ◽  
Vol 9 (2) ◽  
pp. 243 ◽  
Author(s):  
K. Basden ◽  
D. W. Cooper ◽  
E. M. Deane
Keyword(s):  
Lymph Nodes ◽  
Immunoglobulin G ◽  
Lymphoid Tissue ◽  
Post Partum ◽  
Tammar Wallaby ◽  
Didelphis Virginiana ◽  
Lymphoid Tissues ◽  
Macropus Eugenii ◽  
Germinal Centres

A study has been made of the development of four lymphoid tissues from birth to maturity in the tammar wallaby Macropus eugenii —the cervical and thoracic thymus, lymph nodes and gut-associated lymphoid tissue (GALT). The development of these tissues in the tammar wallaby is similar to that in two other marsupials, the quokka Setonix brachyurus and the Virginian opossum Didelphis virginiana. Lymphocytes were first detected in the cervical thymus of the tammar at Day 2 post partum and in the thoracic thymus at Day 6. They were subsequently detected in lymph nodes at Day 4 and in the spleen by Day 12 but were not apparent in the GALT until around Day 90 post partum. By Day 21, the cervical thymus had developed distinct areas of cortex and medulla and Hassall’s corpuscles were apparent. The maturation of other tissues followed with Hassall’s corpuscles in the thoracic thymus by Day 30 and nodules and germinal centres in the lymph nodes by Day 90. Measurement of immunoglobulin G concentrations in the serum of young animals indicated a rise in titre around Day 90 post partum, correlating with the apparent maturation of the lymphoid tissues.

scholarly journals Tunable dynamics of B cell selection in gut germinal centres

Nature ◽  
2020 ◽  
Vol 588 (7837) ◽  
pp. 321-326
Author(s):  
Carla R. Nowosad ◽  
Luka Mesin ◽  
Tiago B. R. Castro ◽  
Christopher Wichmann ◽  
Gregory P. Donaldson ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Selection ◽  
Germinal Centres
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