scholarly journals Seroprevalence and correlates of SARS-CoV-2 neutralizing antibodies from a population-based study in Bonn, Germany

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
N. Ahmad Aziz ◽  
Victor M. Corman ◽  
Antje K. C. Echterhoff ◽  
Marcel A. Müller ◽  
Anja Richter ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Response Rate ◽  
Neutralization Test ◽  
Population Based ◽  
Immunofluorescence Assay ◽  
Test Results ◽  
Community Based ◽  
Population Based Study ◽  
Temporal Course ◽  
Confirmatory Tests

AbstractTo estimate the seroprevalence and temporal course of SARS-CoV-2 neutralizing antibodies, we embedded a multi-tiered seroprevalence survey within an ongoing community-based cohort study in Bonn, Germany. We first assessed anti-SARS-CoV-2 immunoglobulin G levels with an immunoassay, followed by confirmatory testing of borderline and positive test results with a recombinant spike-based immunofluorescence assay and a plaque reduction neutralization test (PRNT). Those with a borderline or positive immunoassay result were retested after 4 to 5 months. At baseline, 4771 persons participated (88% response rate). Between April 24th and June 30th, 2020, seroprevalence was 0.97% (95% CI: 0.72−1.30) by immunoassay and 0.36% (95% CI: 0.21−0.61) when considering only those with two additional positive confirmatory tests. Importantly, about 20% of PRNT+ individuals lost their neutralizing antibodies within five months. Here, we show that neutralizing antibodies are detectable in only one third of those with a positive immunoassay result, and wane relatively quickly.

scholarly journals Seroprevalence and correlates of SARS-CoV-2 neutralizing antibodies: Results from a population-based study in Bonn, Germany

2020 ◽  
Author(s):  
N. Ahmad Aziz ◽  
Victor M Corman ◽  
Antje K.C. Echterhoff ◽  
Anja Richter ◽  
Antonio Schmandke ◽  
...  
Keyword(s):  
Test Performance ◽  
Neutralizing Antibodies ◽  
Hot Flashes ◽  
Population Based ◽  
Community Based ◽  
Population Based Study ◽  
Health Measures ◽  
History Of ◽  
Effective Public Health ◽  
The City

Background Accurate estimates of SARS-CoV-2 seroprevalence are crucial for the implementation of effective public health measures, but are currently largely lacking in regions with low infection rates. This is further complicated by inadequate test performance of many widely used serological assays. We therefore aimed to assess SARS-CoV-2 seroprevalence in a region with low COVID-19 burden, especially focusing on neutralizing antibodies that presumably constitute a major component of acquired immunity. Methods We invited all individuals who were enrolled in the Rhineland Study, an ongoing community-based prospective cohort study in people aged 30 years and above in the city of Bonn, Germany (N=5427). Between April 24th and June 30th, 2020, 4771 (88%) of these individuals participated in the serosurvey. Anti-SARS-CoV-2 IgG levels were measured using an ELISA assay, and all positive or borderline results were subsequently examined through both a recombinant immunofluorescent assay and a plaque reduction neutralisation test (PRNT). Findings Seroprevalence was 0.97% (95% CI: 0.72-1.30) by ELISA and 0.36% (95% CI: 0.21-0.61) by PRNT, and did not vary with either age or sex. All PRNT+ individuals reported having experienced at least one symptom (odds ratio (OR) of PRNT+ for each additional symptom: 1.12 (95% CI: 1.04-1.21)). Apart from living in a household with a SARS-CoV-2 confirmed or suspected person, a recent history of reduced taste or smell, fever, chills/hot flashes, pain while breathing, pain in arms/legs, as well as muscle pain and weakness were significantly associated with the presence of neutralizing antibodies in those with mild to moderate infection (ORs 3.44 to 9.97, all p<0.018). Interpretation Our findings indicate a relatively low SARS-CoV-2 seroprevalence in Bonn, Germany (until June 30th, 2020), with neutralizing antibodies detectable in only one third of those with a positive immunoassay result, implying that almost the entire population in this region remains susceptible to SARS-CoV-2 infection.

scholarly journals Prevalence and service assessment of cataract in Tibetan areas of Sichuan Province, China: population-based study

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e031337 ◽  
Author(s):  
Danba Jiachu ◽  
Ling Jin ◽  
Feng Jiang ◽  
Li Luo ◽  
Hong Zheng ◽  
...  
Keyword(s):  
Visual Impairment ◽  
Response Rate ◽  
Rapid Assessment ◽  
Population Based ◽  
Cross Sectional Study ◽  
Secondary Outcome ◽  
Cross Sectional ◽  
Population Based Study ◽  
Low Prevalence ◽  
Better Than

ObjectivesTo assess the prevalence of visual impairment (VI) and blindness (BL) due to cataract and cataract surgical outcomes in remote dispersed and high-altitude Tibetan areas of China.Design and settingA cross-sectional study was conducted among people aged 50 and above in Tibetan Autonomous Prefecture of Kandze (TAPK), China, in 2017. The Rapid Assessment of Avoidable Blindness protocol was followed.ParticipantsOf 5000 eligible participants, 4764 were examined (response rate 95.3%).Primary and secondary outcome measuresCataract VI was defined as lens opacity at visual acuity (VA) levels of <3/60 (Blindness (BL)), ≥3/60 and <6/60 (severe visual impairment (SVI)), ≥6/60 and <6/18 (moderate visual impairment (MVI)), ≥6/18 and <6/12 (early visual impairment (EVI)).ResultsThe estimated prevalence of cataract BL was 0.61% (95% CI 0.42 to 0.87). With best corrected VA, the estimated prevalence of SVI from cataract was 0.86% (95% CI 0.63 to 1.17); MVI was 2.39% (95% CI 2.00 to 2.87) and EVI was 5.21% (95% CI 4.61 to 5.87). Women in TAPK had a significantly higher prevalence of cataract BL (0.82%, 95% CI 0.54 to 2.15) than men (0.34%, 95% CI 0.16 to 0.70). Women had lower cataract surgical coverage (CSC) by eyes (60.8%, 95% CI 55.5 to 65.8) compared with men (70.1%; 95% CI 63.7 to 75.7). The prevalence of cataract BL was higher among Tibetan (2.28%; 95% CI 1.98 to 2.62) than Han Chinese (1.01%%; 95% CI 0.54% to 1.87%). Overall CSC by person with BL (by better eye) was 82.0% (95% CI 75.2 to 87.6). Among cataract-operated participants, 71.2% had VA equal to or better than 6/18.ConclusionsThe study detected a low prevalence of VI and BL due to cataract with high CSC in the study area compared with many other places in China. Further actions should be taken to improve cataract surgical outcome.

Community-Based Adverse Food Reactions and Anaphylaxis in Children with IgE-Mediated Food Allergy at Age 6 Years: A Population-Based Study

2020 ◽  
Vol 8 (10) ◽  
pp. 3515-3524 ◽  
Author(s):  
Yichao Wang ◽  
Rachel L. Peters ◽  
Kirsten P. Perrett ◽  
Vicki L. McWilliam ◽  
Mimi L.K. Tang ◽  
...  
Keyword(s):  
Food Allergy ◽  
Population Based ◽  
Community Based ◽  
Population Based Study ◽  
Ige Mediated

scholarly journals Priorities in health: what do they mean to Brazilian adults?

2010 ◽  
Vol 26 (4) ◽  
pp. 775-785 ◽  
Author(s):  
Felipe Fossati Reichert ◽  
Marlos Rodrigues Domingues ◽  
Pedro C. Hallal ◽  
Mario Renato Azevedo ◽  
Fernando Vinholes Siqueira ◽  
...  
Keyword(s):  
Physical Activity ◽  
Response Rate ◽  
Population Based ◽  
Healthy Diet ◽  
Rio Grande Do Sul ◽  
Ideal Weight ◽  
Related Factors ◽  
Population Based Study ◽  
Health Related ◽  
The Ideal

We aimed to evaluate how Brazilian adults rank seven well-known health-related factors in terms of importance for health. A population-based study was undertaken in Pelotas, Rio Grande do Sul State, Brazil (N = 3,100; response rate: 96.5%). Individuals ranked three out of seven factors that, in their opinion, were the most important for health. The factors investigated were: "controlling stress", "practicing physical activity regularly", "avoiding drinking in excess", "avoiding smoking", "visiting a doctor regularly", "keeping the ideal weight", and "having a healthy diet". Healthy diet (73.9%), physical activity (59.9%), and visiting a doctor regularly (45.7%) were the most frequently reported factors. Younger subjects and those with higher socioeconomic status were more likely to report physical activity and stress as important factors for health than their counterparts. The importance attributed to health-related factors changes markedly among population subgroups.

Force of infection of dengue serotypes in a population-based study in the northeast of Brazil

2012 ◽  
Vol 141 (5) ◽  
pp. 1080-1088 ◽  
Author(s):  
P. M. S. CASTANHA ◽  
M. T. CORDEIRO ◽  
C. M. T. MARTELLI ◽  
W. V. SOUZA ◽  
E. T. A. MARQUES ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Dengue Infection ◽  
Population Based ◽  
Northeastern Brazil ◽  
Population Based Study ◽  
Force Of Infection ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Frequent Infection ◽  
Dengue Virus Serotype 1

SUMMARYThis study investigated anti-dengue serotype-specific neutralizing antibodies in a random sample of dengue IgG-positive individuals identified in a survey performed in a hyperendemic setting in northeastern Brazil in 2005. Of 323 individuals, 174 (53·8%) had antibodies to dengue virus serotype 1 (DENV-1), 104 (32·2%) to DENV-2 and 301 (93·2%) to DENV-3. Monotypic infections by DENV-3 were the most frequent infection (35·6%). Of 109 individuals aged <15 years, 61·5% presented multitypic infections. The force of infection estimated by a catalytic model was 0·9%, 0·4% and 2·5% person-years for DENV-1, DENV-2 and DENV-3, respectively. By the age of 5 years, about 70%, 30% and 40% of participants were immune to DENV-3, DENV-2 and DENV-1, respectively. The data suggest that infection with DENV-1, -2 and -3 is intense at early ages, demonstrating the need for research efforts to investigate dengue infection in representative population samples of Brazilian children during early infancy.

Migraine Prevalence in Adolescents Aged 13–15: A Student Population‐Based Study in Taiwan

Cephalalgia ◽  
2000 ◽  
Vol 20 (5) ◽  
pp. 479-485 ◽  
Author(s):  
S‐R Lu ◽  
J‐L Fuh ◽  
K‐D Juang ◽  
S‐J Wang
Keyword(s):  
Response Rate ◽  
International Headache Society ◽  
Population Based ◽  
Junior High Schools ◽  
Questionnaire Response ◽  
Population Based Study ◽  
Migraine Headaches ◽  
Migraine Prevalence ◽  
Self Administered Questionnaire

To estimate the lifetime migraine prevalence in school adolescents aged 13–15 in Taiwan, we conducted a self‐administered questionnaire survey in four sampled public junior high schools. Migraine was diagnosed according to the diagnostic criteria of the International Headache Society. A total of 4064 students (1983 boys, 2081 girls) completed the questionnaire (response rate 91.6%). The lifetime prevalence of migraine was 6.8%. It was significantly higher in girls than boys (7.8% vs. 5.7%) and increased with age in both sexes. Students with migraine were more likely to be absent from school because of their headaches than those with non‐migraine headaches (30% vs. 14%, odds ratio (OR) 2.7). They were also more likely to use painkillers for their headaches than their non‐migraine headache peers (72% vs. 40%, OR 4.0). These results suggest that migraine is a common disorder of adolescents in Taiwan and its impact on the quality of life can not be ignored.

scholarly journals 850: Trends in Glucose Challenge test results: A population based study of over a decade

2018 ◽  
Vol 218 (1) ◽  
pp. S507
Author(s):  
Israel Yoles ◽  
Tamar Wainstock ◽  
Eyal Sheiner ◽  
Menashe Shevi ◽  
Asnat Walfisch
Keyword(s):  
Challenge Test ◽  
Population Based ◽  
Test Results ◽  
Population Based Study ◽  
Glucose Challenge Test ◽  
Glucose Challenge
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