DNA methylation inhibitor resets tolerance in autoimmune arthritis

2021 ◽  
Author(s):  
Joanna Clarke
Keyword(s):  
Dna Methylation ◽  
Autoimmune Arthritis ◽  
Methylation Inhibitor ◽  
Dna Methylation Inhibitor

scholarly journals Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

2002 ◽  
Vol 321 (4) ◽  
pp. 591-599 ◽  
Author(s):  
L. Zhou ◽  
X. Cheng ◽  
B.A. Connolly ◽  
M.J. Dickman ◽  
P.J. Hurd ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Dna Methyltransferases ◽  
Methylation Inhibitor ◽  
Dna Methylation Inhibitor ◽  
Covalent Complex

scholarly journals DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5

2019 ◽  
Vol 11 (5) ◽  
Author(s):  
Naohide Kondo ◽  
Genki Tohnai ◽  
Kentaro Sahashi ◽  
Madoka Iida ◽  
Mayumi Kataoka ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Methylation Inhibitor ◽  
Dna Methylation Inhibitor

Combination of DNA methylation inhibitor 5-azacytidine and arsenic trioxide has synergistic activity in myeloma

2009 ◽  
Vol 82 (3) ◽  
pp. 176-183 ◽  
Author(s):  
Guanghua Chen ◽  
Yi Wang ◽  
Haiwen Huang ◽  
Fengru Lin ◽  
Depei Wu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Arsenic Trioxide ◽  
Synergistic Activity ◽  
Methylation Inhibitor ◽  
Dna Methylation Inhibitor

Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells

2005 ◽  
Vol 70 (1) ◽  
pp. 121-133 ◽  
Author(s):  
Tsipi Ben-Kasus ◽  
Zvi Ben-Zvi ◽  
Victor E. Marquez ◽  
James A. Kelley ◽  
Riad Agbaria
Keyword(s):  
Dna Methylation ◽  
Bladder Carcinoma ◽  
Metabolic Activation ◽  
Carcinoma Cells ◽  
Human Bladder ◽  
Methylation Inhibitor ◽  
Dna Methylation Inhibitor ◽  
Bladder Carcinoma Cells

DNA Methylation Inhibitor Zebularine Confers Stroke Protection in Ischemic Rats

2015 ◽  
Vol 6 (4) ◽  
pp. 296-300 ◽  
Author(s):  
Hua Dock ◽  
Annette Theodorsson ◽  
Elvar Theodorsson
Keyword(s):  
Dna Methylation ◽  
Methylation Inhibitor ◽  
Dna Methylation Inhibitor

scholarly journals DNA methylation affects photoperiodic tuberization in potato (Solanum tuberosum L.) by mediating the expression of genes related to the photoperiod and GA pathways

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Yanjun Ai ◽  
Shenglin Jing ◽  
Zhengnan Cheng ◽  
Botao Song ◽  
Conghua Xie ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Solanum Tuberosum L ◽  
Tuber Initiation ◽  
Short Day ◽  
Photoperiodic Flowering ◽  
Differentially Methylated Genes ◽  
Wide Range ◽  
Methylation Inhibitor ◽  
Dna Methylation Inhibitor ◽  
Photoperiod Sensitive

AbstractOvercoming short-day-dependent tuberization to adapt to long-day conditions is critical for the widespread geographical success of potato. The genetic pathways of photoperiodic tuberization are similar to those of photoperiodic flowering. DNA methylation plays an important role in photoperiodic flowering. However, little is known about how DNA methylation affects photoperiodic tuberization in potato. Here, we verified the effect of a DNA methylation inhibitor on photoperiodic tuberization and compared the DNA methylation levels and differentially methylated genes (DMGs) in the photoperiodic tuberization process between photoperiod-sensitive and photoperiod-insensitive genotypes, aiming to dissect the role of DNA methylation in the photoperiodic tuberization of potato. We found that a DNA methylation inhibitor could promote tuber initiation in strict short-day genotypes. Whole-genome DNA methylation sequencing showed that the photoperiod-sensitive and photoperiod-insensitive genotypes had distinct DNA methylation modes in which few differentially methylated genes were shared. Transcriptome analysis confirmed that the DNA methylation inhibitor regulated the expression of the key genes involved in the photoperiod and GA pathways to promote tuber initiation in the photoperiod-sensitive genotype. Comparison of the DNA methylation levels and transcriptome levels identified 52 candidate genes regulated by DNA methylation that were predicted to be involved in photoperiodic tuberization. Our findings provide a new perspective for understanding the relationship between photoperiod-dependent and GA-regulated tuberization. Uncovering the epigenomic signatures of these pathways will greatly enhance potato breeding for adaptation to a wide range of environments.

Sign in / Sign up

Export Citation Format

Share Document