scholarly journals Breast Cancer Multi-classification from Histopathological Images with Structured Deep Learning Model

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Zhongyi Han ◽  
Benzheng Wei ◽  
Yuanjie Zheng ◽  
Yilong Yin ◽  
Kejian Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Deep Learning ◽  
Learning Model ◽  
Histopathological Images ◽  
Multi Classification ◽  
Deep Learning Model

scholarly journals Deep learning model for fully automated breast cancer detection system from thermograms

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262349
Author(s):  
Esraa A. Mohamed ◽  
Essam A. Rashed ◽  
Tarek Gaber ◽  
Omar Karam
Keyword(s):  
Breast Cancer ◽  
Deep Learning ◽  
Cancer Detection ◽  
Detection System ◽  
Diagnostic Technique ◽  
Learning Model ◽  
The Body ◽  
Breast Cancer Detection ◽  
Benchmark Database ◽  
Deep Learning Model

Breast cancer is one of the most common diseases among women worldwide. It is considered one of the leading causes of death among women. Therefore, early detection is necessary to save lives. Thermography imaging is an effective diagnostic technique which is used for breast cancer detection with the help of infrared technology. In this paper, we propose a fully automatic breast cancer detection system. First, U-Net network is used to automatically extract and isolate the breast area from the rest of the body which behaves as noise during the breast cancer detection model. Second, we propose a two-class deep learning model, which is trained from scratch for the classification of normal and abnormal breast tissues from thermal images. Also, it is used to extract more characteristics from the dataset that is helpful in training the network and improve the efficiency of the classification process. The proposed system is evaluated using real data (A benchmark, database (DMR-IR)) and achieved accuracy = 99.33%, sensitivity = 100% and specificity = 98.67%. The proposed system is expected to be a helpful tool for physicians in clinical use.

scholarly journals Evaluating the Accuracy of Breast Cancer and Molecular Subtype Diagnosis by Ultrasound Image Deep Learning Model

2021 ◽  
Vol 11 ◽  
Author(s):  
Xianyu Zhang ◽  
Hui Li ◽  
Chaoyun Wang ◽  
Wen Cheng ◽  
Yuntao Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Deep Learning ◽  
Sensitivity And Specificity ◽  
Molecular Subtypes ◽  
Learning Model ◽  
Breast Ultrasound ◽  
Ultrasound Images ◽  
Test Set ◽  
External Test ◽  
Deep Learning Model

Background: Breast ultrasound is the first choice for breast tumor diagnosis in China, but the Breast Imaging Reporting and Data System (BI-RADS) categorization routinely used in the clinic often leads to unnecessary biopsy. Radiologists have no ability to predict molecular subtypes with important pathological information that can guide clinical treatment.Materials and Methods: This retrospective study collected breast ultrasound images from two hospitals and formed training, test and external test sets after strict selection, which included 2,822, 707, and 210 ultrasound images, respectively. An optimized deep learning model (DLM) was constructed with the training set, and the performance was verified in both the test set and the external test set. Diagnostic results were compared with the BI-RADS categorization determined by radiologists. We divided breast cancer into different molecular subtypes according to hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) expression. The ability to predict molecular subtypes using the DLM was confirmed in the test set.Results: In the test set, with pathological results as the gold standard, the accuracy, sensitivity and specificity were 85.6, 98.7, and 63.1%, respectively, according to the BI-RADS categorization. The same set achieved an accuracy, sensitivity, and specificity of 89.7, 91.3, and 86.9%, respectively, when using the DLM. For the test set, the area under the curve (AUC) was 0.96. For the external test set, the AUC was 0.90. The diagnostic accuracy was 92.86% with the DLM in BI-RADS 4a patients. Approximately 70.76% of the cases were judged as benign tumors. Unnecessary biopsy was theoretically reduced by 67.86%. However, the false negative rate was 10.4%. A good prediction effect was shown for the molecular subtypes of breast cancer with the DLM. The AUC were 0.864, 0.811, and 0.837 for the triple-negative subtype, HER2 (+) subtype and HR (+) subtype predictions, respectively.Conclusion: This study showed that the DLM was highly accurate in recognizing breast tumors from ultrasound images. Thus, the DLM can greatly reduce the incidence of unnecessary biopsy, especially for patients with BI-RADS 4a. In addition, the predictive ability of this model for molecular subtypes was satisfactory,which has specific clinical application value.

scholarly journals Deep Learning Generates Custom-made Logistic Regression Models for Explaining how Breast Cancer Subtypes are Classified

2021 ◽  
Author(s):  
Takuma Shibahara ◽  
Chisa Wada ◽  
Yasuho Yamashita ◽  
Kazuhiro Fujita ◽  
Masamichi Sato ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Logistic Regression ◽  
Deep Learning ◽  
Linear Model ◽  
Regression Models ◽  
Learning Model ◽  
Logistic Regression Models ◽  
Custom Made ◽  
Meta Learning ◽  
Deep Learning Model

Abstract Breast cancer is the most frequently found cancer in women and the one most often subjected to genetic analysis. Nonetheless, it has been causing the largest number of women's cancer-related deaths. PAM50, the intrinsic subtype assay for breast cancer, is beneficial for diagnosis but does not explain each subtype’s mechanism. Deep learning can predict the subtypes from genetic information more accurately than conventional statistical methods. However, the previous studies did not directly use deep learning to examine which genes associate with the subtypes. To reveal the mechanisms embedded in the PAM50 subtypes, we developed an explainable deep learning model called a point-wise linear model, which uses meta-learning to generate a custom-made logistic regression for each sample. We developed an explainable deep learning model called a point-wise linear model, which uses meta-learning to generate a custom-made logistic regression for each sample. Logistic regression is familiar to physicians, and we can use it to analyze which genes are important for prediction. The custom-made logistic regression models generated by the point-wise linear model used the specific genes selected in other subtypes compared to the conventional logistic regression model: the overlap ratio is less than twenty percent. Analyzing the point-wise linear model’s inner state, we found that the point-wise linear model used genes relevant to the cell cycle-related pathways.

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