scholarly journals Investigation of the prevalence of Cognitive Impairment and its risk factors within the elderly population in Shanghai, China

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Longbing Ren ◽  
Yongtao Zheng ◽  
Lezhou Wu ◽  
Yijun Gu ◽  
Yusheng He ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Elderly Population ◽  
The Elderly

scholarly journals GW28-e0223 Investigation of the prevalence of Cognitive Impairment and its risk factors within the elderly population in Shanghai, China

2017 ◽  
Vol 70 (16) ◽  
pp. C71-C72
Author(s):  
Longbing Ren ◽  
Yongtao Zheng ◽  
Yijun Gu ◽  
Yusheng He ◽  
Bo Jiang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Elderly Population ◽  
The Elderly

scholarly journals Post-infection cognitive impairments in a cohort of elderly patients with COVID-19

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Yu-Hui Liu ◽  
Ye-Ran Wang ◽  
Qing-Hua Wang ◽  
Yang Chen ◽  
Xian Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Elderly Patients ◽  
Cognitive Decline ◽  
Post Infection ◽  
Elderly Population ◽  
The Elderly ◽  
Cognitive Status ◽  
Increased Risk

Abstract Background Understanding the long-term effects of coronavirus disease 2019 (COVID-19) on cognitive function is essential for monitoring the cognitive decline in the elderly population. This study aims to assess the current cognitive status and the longitudinal cognitive decline in elderly patients recovered from COVID-19. Methods This cross-sectional study recruited 1539 COVID-19 inpatients aged over 60 years who were discharged from three COVID-19-designated hospitals in Wuhan, China, from February 10 to April 10, 2020. In total, 466 uninfected spouses of COVID-19 patients were selected as controls. The current cognitive status was assessed using a Chinese version of the Telephone Interview of Cognitive Status-40 (TICS-40) and the longitudinal cognitive decline was assessed using an Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). Cognitive assessments were performed 6 months after patient discharge. Results Compared with controls, COVID-19 patients had lower TICS-40 scores and higher IQCODE scores [TICS-40 median (IQR): 29 (25 to 32) vs. 30 (26 to 33), p < 0.001; IQCODE median (IQR): 3.19 (3.00 to 3.63) vs. 3.06 (3.00 to 3.38), p < 0.001]. Severe COVID-19 patients had lower TICS-40 scores and higher IQCODE scores than non-severe COVID-19 patients [TICS-40 median (IQR): 24 (18 to 28) vs. 30 (26 to 33), p < 0.001; IQCODE median (IQR): 3.63 (3.13 to 4.31) vs. 3.13 (3.00 to 3.56), p < 0.001] and controls [TICS-40 median (IQR): 24 (18 to 28) vs. 30 (26 to 33), p < 0.001; IQCODE median (IQR) 3.63 (3.13 to 4.31) vs. 3.06 (3.00 to 3.38), p < 0.001]. Severe COVID-19 patients had a higher proportion of cases with current cognitive impairment and longitudinal cognitive decline than non-severe COVID-19 patients [dementia: 25 (10.50 %) vs. 9 (0.69 %), p < 0.001; Mild cognitive impairment (MCI): 60 (25.21 %) vs. 63 (4.84 %), p < 0.001] and controls [dementia: 25 (10.50 %) vs. 0 (0 %), p < 0.001; MCI: 60 (25.21 %) vs. 20 (4.29 %), p < 0.001)]. COVID-19 severity, delirium and COPD were risk factors of current cognitive impairment. Low education level, severe COVID-19, delirium, hypertension and COPD were risk factors of longitudinal cognitive decline. Conclusions Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with an increased risk of long-term cognitive decline in elderly population. COVID-19 patients, especially severe patients, should be intensively monitored for post-infection cognitive decline.

A Short Mental Status Questionnaire

1982 ◽  
Vol 1 (1-2) ◽  
pp. 16-20 ◽  
Author(s):  
Duncan Robertson ◽  
Kenneth Rockwood ◽  
Paul Stolee
Keyword(s):  
Cognitive Impairment ◽  
Mental Status ◽  
Clinical Assessment ◽  
Elderly Population ◽  
The Elderly ◽  
False Positives ◽  
False Negatives ◽  
Institutionalized Elderly ◽  
Severe Cognitive Impairment ◽  
Mild Impairment

ABSTRACTA mental status questionnaire (MSQ) developed tor use in surveys of the non-institutionalized elderly has been validated against clinical assessment. The MSQ identities moderate and severe cognitive impairment in the elderly. However, using the suggested scoring subjects with mild impairment cannot be separated from normals.The test is short, acceptable and reproducible and rate for false-positives and false-negatives fall well within acceptable limits for use in estimating the prevalence of dementia in the non-institutionalized elderly population.

Transversal and longitudinal studies of risk factors for coronary heart disease in the elderly population of Sa˜o Paulo

1994 ◽  
Vol 109 (1-2) ◽  
pp. 15
Author(s):  
M.S. Cendoroglo ◽  
T.L.R. Martinez ◽  
L.E.S. Almeida Pinto ◽  
F.R. Gonçalves ◽  
T.E.C. Rosa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Longitudinal Studies ◽  
Elderly Population ◽  
The Elderly

Prevalence of Cardiovascular Risk Factors in the Elderly Population of Alentejo

2020 ◽  
pp. 185-195
Author(s):  
Maria do Céu Mendes Pinto Marques ◽  
Ana Filipa Pereira Vaz ◽  
Ana Sofia Emídio Cardoso Leite ◽  
Cláudia Sofia Araújo ◽  
Cláudia Roque Condeço ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Elderly Population ◽  
Research Question ◽  
National Level ◽  
The Elderly ◽  
Regional Level ◽  
Age Group ◽  
Prevalence Studies

The objective of this chapter is to identify cardiovascular risk factors in the elderly and their prevalence in the elderly population of Alentejo. The research question was elaborated according to the PI[C]OD methodology. The prevalence studies included allow the authors to identify the risk factors with the greatest impact on cardiovascular diseases, with the analysis of at least one of the factors (hypertension, diabetes, smoking, obesity, hypercholesterolemia, alcoholism, and sedentary lifestyle) and their prevalence in the elderly from the region of Alentejo. The results present the prevalence of cardiovascular risk factors, mainly at the national level, compared to those at the regional level, with a small number of exclusive studies in the Alentejo region, while simultaneously disaggregating the results by age group. From the data obtained, it can be concluded that the prevalence of risk factors is generally increased in the elderly population and, consequently, in Alentejo, because it is a region in the interior of the country that is predominantly rural and very old.

Risk factors for overactive bladder in the elderly population: A community-based study with face-to-face interview

2010 ◽  
Vol 18 (3) ◽  
pp. 212-218 ◽  
Author(s):  
Yoshihiro Ikeda ◽  
Haruo Nakagawa ◽  
Kaori Ohmori-Matsuda ◽  
Atsushi Hozawa ◽  
Yayoi Masamune ◽  
...  
Keyword(s):  
Risk Factors ◽  
Overactive Bladder ◽  
Elderly Population ◽  
The Elderly ◽  
Community Based ◽  
Face To Face

scholarly journals Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Jing Yan ◽  
Ailin Luo ◽  
Rao Sun ◽  
Xiaole Tang ◽  
Yilin Zhao ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Elderly Population ◽  
Cognitive Deficit ◽  
Neurological Complication ◽  
Postoperative Cognitive Dysfunction ◽  
The Elderly ◽  
Dependent Manner ◽  
Promising Avenue ◽  
Tau Acetylation

Postoperative cognitive dysfunction (POCD) is a sever postsurgical neurological complication in the elderly population. As the global acceleration of population ageing, POCD is proved to be a great challenge to the present labor market and healthcare system. In the present study, our findings showed that tau acetylation mediated by SIRT1 deficiency resulted in tau hyperphosphorylation in the hippocampus of the aged POCD model and consequently contributed to cognitive impairment. Interestingly, pretreatment with resveratrol almost restored the expression of SIRT1, reduced the levels of acetylated tau and hyperphosphorylated tau in the hippocampus, and improved the cognitive performance in the behavioral tests. What is more, we observed that microglia-derived neuroinflammation resulting from SIRT1 inhibition in microglia probably aggravated the tau acetylation in cultured neurons in vitro. Our findings supported the notion that activation SIRT1 provided dually beneficial effect in the aged POCD model. Taken together, our findings provided the initial evidence that tau acetylation was associated with cognitive impairment in the aged POCD model and paved a promising avenue to prevent POCD by inhibiting tau acetylation in a SIRT1-dependent manner.

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