scholarly journals The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Barbara Żyżyńska-Granica ◽  
Bartosz Trzaskowski ◽  
Małgorzata Dutkiewicz ◽  
Oliwia Zegrocka-Stendel ◽  
Maja Machcińska ◽  
...  
Keyword(s):  
Gamma Chain ◽  
Common Gamma Chain ◽  
Cytokine Inhibitor ◽  
Anti Inflammatory

Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor beta-chain

1997 ◽  
Vol 272 (5) ◽  
pp. G1201-G1208 ◽  
Author(s):  
A. C. Stevens ◽  
J. Matthews ◽  
P. Andres ◽  
V. Baffis ◽  
X. X. Zheng ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Interleukin 2 ◽  
Receptor Protein ◽  
Beta Chain ◽  
Gamma Chain ◽  
T84 Cells ◽  
Colonic Epithelial Cells ◽  
Common Gamma Chain ◽  
Interleukin 15 ◽  
The Common

Interleukin-15 (IL-15) shares many biological functions with interleukin-2 (IL-2) due to common receptor components. IL-15 binds to the IL-2 receptor (IL-2R) beta-chain and the common gamma-chain receptor in addition to one other IL-15 binding receptor protein (IL-15R alpha). Both IL-2R beta- and gamma-chains are required to promote cell growth in hematopoietic cells. The colonic cryptlike epithelial cell line T84 contains the common gamma-chain but lacks the IL-2R beta-chain. We report IL-15R alpha-chain mRNA in T84 cells with the use of reverse transcriptase-polymerase chain reaction. T84 and normal colonic epithelial cells bind a FLAG-IL-15 fusion protein in immunoperoxidase and flow cytometric experiments. In addition, IL-15, but not IL-2, accelerates and enhances the development of transepithelial resistance across T84 monolayers in a dose-dependent fashion. We conclude that normal and T84 colonic epithelial cells express IL-15R alpha and are able to bind IL-15. IL-15 can deliver a nonproliferative functional signal in the absence of IL-2R beta-chain in T84 cells.

scholarly journals The role of soluble common gamma chain in autoimmune disease

2015 ◽  
Vol 48 (1) ◽  
pp. 10 ◽  
Author(s):  
Byunghyuk Lee ◽  
Changwan Hong
Keyword(s):  
Autoimmune Disease ◽  
Gamma Chain ◽  
Common Gamma Chain

Alternative Splicing Rescues Loss of Common Gamma Chain Function and Results in IL-21R-like Deficiency

2019 ◽  
Vol 39 (2) ◽  
pp. 207-215 ◽  
Author(s):  
David Illig ◽  
Marta Navratil ◽  
Jadranka Kelečić ◽  
Raffaele Conca ◽  
Iva Hojsak ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Gamma Chain ◽  
Common Gamma Chain

New insights of common gamma chain in hematological malignancies

Cytokine ◽  
2017 ◽  
Vol 89 ◽  
pp. 179-184 ◽  
Author(s):  
Tae Sik Goh ◽  
Changwan Hong
Keyword(s):  
Hematological Malignancies ◽  
Gamma Chain ◽  
Common Gamma Chain

Suspected Atypical Common Gamma Chain Severe Combined Immunodeficiency

2006 ◽  
Vol 117 (2) ◽  
pp. S288
Author(s):  
A. Chandra ◽  
D. Webster ◽  
K.C. Gilmour ◽  
D.S. Kumararatne ◽  
A. Thrasher
Keyword(s):  
Severe Combined Immunodeficiency ◽  
Combined Immunodeficiency ◽  
Gamma Chain ◽  
Common Gamma Chain

Mutations in the gene for the common gamma chain (γ

1998 ◽  
Vol 103 (6) ◽  
pp. 730
Author(s):  
Sebastian D. Fugmann ◽  
Susanna Müller ◽  
Wilhelm Friedrich ◽  
Claus R. Bartram ◽  
K. Schwarz
Keyword(s):  
Gamma Chain ◽  
Common Gamma Chain ◽  
The Common
Sign in / Sign up

Export Citation Format

Share Document