scholarly journals Macular vessel density and foveal avascular zone parameters in patients after acute primary angle closure determined by OCT angiography

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kangcheng Liu ◽  
Huizhuo Xu ◽  
Haibo Jiang ◽  
Hua Wang ◽  
Pingbao Wang ◽  
...  
Keyword(s):  
Early Stage ◽  
Normal Subjects ◽  
Vessel Density ◽  
Foveal Avascular Zone ◽  
Angle Closure ◽  
Acute Primary Angle Closure ◽  
Primary Angle Closure ◽  
Circularity Index ◽  
Avascular Zone ◽  
And Control

Abstract This study analyzed the optical coherence tomography angiography (OCTA) macular parameters in primary angle-closure glaucoma (PACG) patients after acute primary angle closure (APAC) episodes. Thirty-three patients with 33 APAC eyes and 33 primary angle closure suspect (PACS) eyes and 33 age-matched normal subjects (controls) were enrolled. Macular vessel density (VD) in central, inner, outer and full regions and foveal avascular zone (FAZ) parameters (area, perimeter and circularity index) were compared between APAC, PACS, and control eyes. For resolved APAC eyes, the VD in each macular region was significantly lower than that in control eyes, with less central and inner macular VD than PACS eyes. The central macular VD was significantly lower in PACS eyes than in controls. There was no difference in FAZ area and perimeter between APAC, PACS, and control eyes. FAZ circularity was highest in control eyes, followed by PACS eyes, and lowest in APAC eyes. The AUC, sensitivity and specificity of FAZ circularity were 0.944, 93.9% and 84.8%, respectively, in APAC eyes and 0.881, 84.8% and 81.8%, respectively, in PACS eyes. Therefore, FAZ circularity had the best discrimination capability for detecting both APAC and PACS eyes. Macular assessment with OCTA could provide an accurate early-stage diagnostic tool for PACG.

scholarly journals Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode

2019 ◽  
Vol 60 (2) ◽  
pp. 552 ◽  
Author(s):  
Sasan Moghimi ◽  
Mona SafiZadeh ◽  
Masoud Aghsaei Fard ◽  
Nazgol Motamed-Gorji ◽  
Nassim Khatibi ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Vessel Density ◽  
Angle Closure ◽  
Acute Primary Angle Closure ◽  
Primary Angle Closure

scholarly journals Optical Coherence Tomography Angiography of The Macular Microcirculation in Acute Primary Angle Closure Treated With Phacoemulsification

2021 ◽  
Author(s):  
Lin Fu ◽  
Yau Kei Chan ◽  
Jia Fang ◽  
Junbo Liu ◽  
Shumei Wen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Vessel Density ◽  
Angle Closure ◽  
Field Pattern ◽  
Control Group ◽  
Optical Coherence ◽  
Acute Primary Angle Closure ◽  
Primary Angle Closure ◽  
Normal Individuals

Abstract Purpose To measure the changes of macular microcirculation in cases with unilateral acute primary angle closure (APAC) who were managed by phacoemulsification. Methods Patients with unilateral APAC and managed by phacoemulsification were enrolled. The contralateral unaffected eyes were served as fellow group, and normal individuals were recruited as control group. Optical coherence tomography angiography (OCT-A) was performed to analyse the macular whole image vessel density (wiVD) and parafoveal vessel density (pfVD). The retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses were assessed using spectral-domain optical coherence tomography. Results A total of 36 APAC patients and 35 eyes from 35 normal individuals were recruited. In the APAC eyes, the mean wiVD (42.1% ± 3.7%) and pfVD (45.2% ± 3.8%) in the superficial layers (wiVD-SL and pfVD-SL) were both significantly reduced, compared to fellow eyes (45.7% ± 3.1%, 48.7% ±3.1%) and control eyes (44.4% ± 4.7%, 47.4% ± 5.1%) (P < 0.05). They were all statistically correlated with RNFL, GCC, visual field pattern standard deviation (PSD), and mean deviation (MD). Conclusion The macular OCT-A parameters including wiVD-SL and pfVD-SL were significantly reduced in the eyes with APAC compared the fellow unaffected eyes and normal control eyes. They were correlated well with RNFL, GCC, PSD and MD. The macular vessel density parameters may help monitor the progression of APAC.

scholarly journals Vessel Density and Structural Measurements in Primary Angle-Closure Suspect Glaucoma Using Optical Coherence Tomography Angiography

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Yi Zha ◽  
Juanjuan Chen ◽  
Shuyu Liu ◽  
Jinfei Zhuang ◽  
Jianqiu Cai
Keyword(s):  
Retinal Vessel ◽  
Normal Subjects ◽  
Vessel Density ◽  
Angle Closure ◽  
Control Group ◽  
Fiber Layer ◽  
Primary Angle Closure ◽  
Rnfl Thickness ◽  
Significant Difference ◽  
Retinal Vessel Density

Purpose. To measure the macular retinal vessel density (VD) and peripapillary retinal nerve fiber layer (RNFL) in primary angle-closure suspects (PACS) by Angio-OCT to be compared with normal subjects. Methods. Primary angle-closure suspect patients and normal subjects were enrolled in this study. The demographic and clinical characteristics of all subjects, such as RNFL thickness, retinal vessel density, and ocular perfusion pressure, were compared. Results. No significant difference was found in both groups on age, sex distribution, intraocular pressure (IOP), and retinal vessel density. The PACS group exhibited significantly thicker RNFL thickness compared with the control group. The deep vessel density was negatively associated with age ( P = − 0.034 ), while IOP had negative association with ACD ( P = − 0.019 ). OPP was independently associated with RNFL ( B = 0.334 , P = 0.038 ) in the PACS group. Conclusions. OCTA showed significant thicker change on RNFL in the PACS group. Only OPP was independently associated with RNFL in the PACS group.

scholarly journals A Study on Changes in Plasma Cholinesterase in Patients with Acute Primary Angle Closure

2021 ◽  
Author(s):  
Tian Tian ◽  
Yu Cai ◽  
Mei Li ◽  
Yuan Fang ◽  
Yingzi Pan
Keyword(s):  
Pearson Correlation ◽  
Case Series ◽  
Normal Subjects ◽  
Plasma Cholinesterase ◽  
Angle Closure ◽  
Retrospective Case ◽  
Acute Primary Angle Closure ◽  
Primary Angle Closure ◽  
Blood Biochemical ◽  
Significant Difference

Abstract Purpose To analyze the differences in plasma cholinesterase (pChE) among patients with acute primary angle closure (APAC), patients with chronic primary angle closure glaucoma (CPACG) and normal people scheduled for cataract surgery and to analyze the relationship between intraocular pressure (IOP) and pChE in order to explore the significance of pChE in the pathogenesis of glaucoma. Methods Retrospective case series. Nighty-four patients with APAC, 72 patients with CPACG and 95 normal controls were enrolled in this study. All patients excluding those with diseases that may affect pChE underwent routine blood biochemical examination. Pearson correlation analysis was used to further analyze the correlation of IOP with pChE. Results There was no significant difference in age or sex among the three groups. The difference in IOP among the APAC (43.8 ± 12.2 mmHg), CPACG (25.6 ± 7.4 mmHg) and normal groups (13.6 ± 1.8 mmHg) was significant (P = 0.000). There was a significant difference in pChE between patients with APAC (7450.89 ± 1748.49 IU/L) and normal subjects (7994.68 ± 1321.90 IU/L) (P = 0.000) and between patients with APAC and those with CPACG (7969.44 ± 1572.14 IU/L) (P = 0.000). There was no significant difference in pChE between CPACG patients and normal subjects (P = 0.932). There was a moderate negative correlation between IOP and pChE in APAC patients (r = -0.410, P = 0.000), while there was no significant correlation in CPACG patients (P = 0.228) or normal subjects (P = 0.341). Conclusion APAC patients with higher IOP had lower pChE, which may have been related to IOP-induced neuroinflammation. It may provide a new strategy for optic nerve protection in glaucoma patients.

Vessel density and retinal nerve fibre layer thickness following acute primary angle closure

2019 ◽  
Vol 104 (8) ◽  
pp. 1103-1108 ◽  
Author(s):  
Sasan Moghimi ◽  
Mona SafiZadeh ◽  
Benjamin Y Xu ◽  
Masoud Aghsaei Fard ◽  
Nassim Khatibi ◽  
...  
Keyword(s):  
Nerve Fibre ◽  
Multiple Logistic Regression Analysis ◽  
Multivariable Analysis ◽  
Retinal Nerve Fibre Layer ◽  
Vessel Density ◽  
Angle Closure ◽  
Acute Primary Angle Closure ◽  
Primary Angle Closure ◽  
Fibre Layer ◽  
Nerve Fibre Layer

BackgroundTo evaluate changes in circumpapillary vessel density (cpVD) and retinal nerve fibre layer (cpRNFL) thickness after a successfully treated episode of acute primary angle closure (APAC) and to identify factors associated with glaucoma progression in these eyes.MethodsTwenty-six patients successfully treated for a unilateral episode of APAC were included in this prospective study. Optical coherence tomography (OCT) cpRNFL thickness and OCT angiography (OCTA) cpVD were compared between 2 and 8 months after treatment. Multiple logistic regression analysis was conducted to identify factors that influenced cpRNFL outcome.ResultscpRNFL thicknesses was thinner in the affected eye (94.0 µm (95% CI: 87.3 to 100.8)) than in the unaffected fellow eye (103.1 µm (99.3 to 106.9)) at 2 months (p=0.039). The cpRNFL thickness of the affected eye decreased 8 months after remission (89.5 µm (84 to 95)), but was unchanged in the unaffected eye. Although cpVD was significantly lower (p=0.001) in APAC eyes 2 months after treatment (56.7% (53.8 to 59.7)) compared with fellow eyes (62.9% (61.4 to 64.4)), there was no significant change in cpVD of the affected eye between 2 and 8 months. In the multivariable analysis, the only factor that was associated with cpRNFL progression was lower cpVD at 2 months after APAC remission (OR=1.79, p=0.036).ConclusionEarly reductions of the vessel density and long-term decrease in cpRNFL thickness were observed during the first 8 months after an APAC attack. A lower vessel density at 2 months was the best predictor of conversion to an abnormal cpRNFL thickness. Glaucomatous progression should be suspected in eyes with lower vessel density even after remission of an episode of APAC.

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