scholarly journals Small rise in written complaints for dental and GP practices

BDJ ◽  
2018 ◽  
Vol 225 (6) ◽  
pp. 470-470
Keyword(s):  
Small Rise

Turnover of Human Extrinsic (Tissue-Type) Plasminogen Activator in Rabbits

1981 ◽  
Vol 46 (03) ◽  
pp. 658-661 ◽  
Author(s):  
C Korninger ◽  
J M Stassen ◽  
D Collen
Keyword(s):  
Plasminogen Activator ◽  
Intravenous Injection ◽  
Active Site ◽  
Half Life ◽  
Degradation Products ◽  
Gel Filtration ◽  
Tissue Type ◽  
Organ Distribution ◽  
Small Rise

SummaryThe turnover of highly purified human extrinsic plasminogen activator (EPA) (one- and two-chain form) was studied in rabbits. Following intravenous injection, EPA-activity declined rapidly. The disappearance rate of EPA from the plasma could adequately be described by a single exponential term with a t ½ of approximately 2 min for both the one-chain and two-chain forms of EPA.The clearance and organ distribution of EPA was studied by using 125I-labeled preparations. Following intravenous injection of 125I-1abeled EPA the radioactivity disappeared rapidly from the plasma also with a t ½ of approximately 2 min down to a level of 15 to 20 percent, followed by a small rise of blood radioactivity. Gel filtration of serial samples revealed that the secondary increase of the radioactivity was due to the reappearance of radioactive breakdown products in the blood. Measurement of the organ distribution of 125I at different time intervals revealed that EPA was rapidly accumulated in the liver, followed by a release of degradation products in the blood.Experimental hepatectomy markedly prolonged the half-life of EPA in the blood. Blocking the active site histidine of EPA had no effect on the half-life of EPA in blood nor on the gel filtration patterns of 125I in serial plasma samples.It is concluded that human EPA is rapidly removed from the blood of rabbits by clearance and degradation in the liver. Recognition by the liver does not require a functional active site in the enzyme. Neutralization in plasma by protease inhibitors does not represent a significant pathway of EPA inactivation in vivo.

PITUITARY-ADRENAL RECOVERY FOLLOWING LONG-TERM CORTICOSTEROID THERAPY

1966 ◽  
Vol 51 (1) ◽  
pp. 63-70 ◽  
Author(s):  
P. F. Roe ◽  
D. M. Mitchell ◽  
G. W. Pennington
Keyword(s):  
Corticosteroid Therapy ◽  
Adrenocortical Function ◽  
Endocrine Disorders ◽  
Marked Rise ◽  
Underlying Condition ◽  
Normal Limits ◽  
Small Rise ◽  
The Mean ◽  
Corticosteroid Drugs

ABSTRACT Adrenocortical function was assessed in 20 patients receiving long-term corticosteroid drugs for a variety of non-endocrine disorders. In all cases plasma 17-hydroxycorticosteroids (17-OHCS) levels were within or above normal limits 48 hours after abruptly stopping their drugs and a further marked rise occurred in 7 patients given metyrapone for 24 h. Urinary 17-OHCS excretion did not show a parallel rise. Taking the group as a whole, a small rise in the mean output occurred 48 hours after stopping therapy, and a further slightly greater rise followed metyrapone. 3 patients had a relapse of their underlying condition during the test in spite of normal plasma and urinary 17-OHCS levels.

EFFECT OF LOCALLY IMPLANTED OESTROGEN ON THE RESPONSE OF THE RAT'S LACTATING MAMMARY GLAND TO OXYTOCIN

1973 ◽  
Vol 73 (4) ◽  
pp. 700-712 ◽  
Author(s):  
J. D. Bruce ◽  
X. Cofre ◽  
V. D. Ramirez
Keyword(s):  
Mammary Gland ◽  
Mammary Glands ◽  
Myoepithelial Cells ◽  
Recording System ◽  
Saline Infusion ◽  
High Dose ◽  
Low Doses ◽  
Milk Ejection ◽  
Lactating Mammary Gland ◽  
Small Rise

ABSTRACT On the day following delivery (day 1 of lactation) one abdominal mammary gland was implanted with oestrogen and the contralateral gland received an empty needle. At 2, 5 or 10 days of lactation the rats were anaesthetized with pentobarbital and the nipples of both abdominal glands were cannulated and their pressures recorded by means of transducers coupled to an amplifier and recording system. The normal mammary glands of 5-day lactating rats responded to very low doses of oxytocin (Syntocinon®, Sandoz) (5× 10−8 mU) with a rhythmic elevation in pressure. However, saline infusion also evoked a small rise in intra-mammary pressure. Earlier (2 days) and later (10 days) in lactation the responses were smaller. Oestrogen decreases significantly the milk ejection response to oxytocin, and the effect was maximal at day 10 of lactation. Histological observations confirmed the diminished reaction of the gland to oxytocin, since the milk was retained in the alveoli of rats bearing a mammary-oestrogen implant. A paradoxical rise in pressure was detected in normal as well as in oestrogen-implanted glands when the lowest dose of oxytocin was injected in lactating rats which had previously received a high dose of oxytocin (50 mU or 500 mU). These results reinforce the hypothesis that oestrogen alters the milk ejection response to oxytocin and that the mechanism is probably related to changes in the contractility of the myoepithelial cells.

scholarly journals Δ14C PEAKS APPEARING IN EARLYWOOD AND LATEWOOD TREE RINGS (AD 770–780) IN NORTHEASTERN ARIZONA

Radiocarbon ◽  
2020 ◽  
pp. 1-6
Author(s):  
J H Park ◽  
J Southon ◽  
JW Seo ◽  
P P Creasman ◽  
W Hong ◽  
...  
Keyword(s):  
Tree Rings ◽  
High Latitude ◽  
Pinus Edulis ◽  
Lateral Transfer ◽  
Late Winter ◽  
National Monument ◽  
Small Rise ◽  
Pinyon Pine

ABSTRACT The AD 775 peak in Δ14C (henceforth, M12) was first measured by Miyake et al. and has since been confirmed globally. Here we present earlywood and latewood Δ14C values from tree rings of pinyon pine (Pinus edulis) from Mummy Cave, Canyon de Chelly National Monument, Chinle, Arizona, USA, for the period AD 770–780. These data reconfirm the timing of M12 and show a small rise in Δ14C in AD 774 latewood. Allowing for the delay in lateral transfer of radiocarbon produced at high latitude, this suggests that 14C peak production occurred in late winter or spring of AD 774. Additionally, Δ14C decreased slightly in the earlywood of AD 775 and increased in the latewood of AD 775 to a higher level than that observed in AD 774.

Capillary permeability: atrial peptide action is independent of "protein effect"

1990 ◽  
Vol 259 (5) ◽  
pp. H1351-H1356 ◽  
Author(s):  
V. H. Huxley ◽  
D. J. Meyer
Keyword(s):  
Hydraulic Conductivity ◽  
Bovine Serum Albumin ◽  
Atrial Natriuretic Peptide ◽  
Rana Pipiens ◽  
Capillary Permeability ◽  
Barrier Properties ◽  
Effective Area ◽  
Small Rise ◽  
Mesenteric Microvessels ◽  
Exchange Vessel

Perfusion of exchange microvessels with the vasoactive hormone, atrial natriuretic peptide (AP), acutely and reversibly elevates hydraulic conductivity (Lp) by mechanisms that are, as yet, unknown. This, the first of two studies to characterize AP responses when perfusate composition was altered, specifically focuses on the action of AP when perfusate albumin was lowered to change the transcapillary barrier properties for water by passive mechanisms (protein effect). Perfusion of frog (Rana pipiens) mesenteric microvessels with 1 nM AP in 10 mg/ml bovine serum albumin (BSA) elevated Lp by a median 2.1-fold (range 1.2-2.7, n = 13) from control levels (10 mg/ml BSA). Reduction of perfusate albumin from 10 to 1 mg/ml elicited a small rise in Lp (1.8-fold, n = 10); Lp rose a further 2.1-fold (n = 6) when 1 nM AP was added to 1 mg/ml BSA. Likewise, protein-free perfusion elevated Lp from a median 2.2 to 5.1 X 10(-7) cm.s-1.cmH2O-1 (n = 11); 1 nM AP in protein-free perfusate elevated Lp a further 2.1-fold (n = 8). Thus, regardless of protein content, the response to the peptide was a consistent, twofold increase in exchange vessel Lp (n = 27). These data are consistent with the suggestion that the AP-activated rise in Lp (twofold) occurs via an increase in the effective area of the transcapillary pathway for water without influencing the selectivity properties of the paracellular, albumin-sensitive portion of the barrier.

Chapter II. The World Economy

1986 ◽  
Vol 117 ◽  
pp. 20-29
Keyword(s):  
Interest Rates ◽  
World Economy ◽  
Oil Prices ◽  
Final Demand ◽  
Total Output ◽  
Cold Winter ◽  
The Us ◽  
The World ◽  
Initial Effect ◽  
Small Rise

Fuller data confirm the impression which we formed in May that OECD countries' total output did not change much in the first quarter. It probably increased by about ¼ per cent, with even this small rise attributable wholly to stock movements in the US. Final demand in the US fell and there were declines in total output in a number of countries, including Japan, Germany, Australia, the Netherlands, Switzerland and possibly Italy (for which there are conflicting estimates), white France achieved only marginal growth. The fall was notably severe in Germany, where construction suffered badly in the cold winter. This probably had a wider impact also, and, in North America at least, the initial effect of the slump in oil prices seems to have been depressive, with drilling activity sharply reduced, especially in the US. There may also have been a tendency for expenditure, perhaps on investment in particular, to be deferred in the expectation of falling prices and interest rates.

Hardness of Domestic Water and Blood Lead Levels

1983 ◽  
Vol 2 (4) ◽  
pp. 645-648 ◽  
Author(s):  
P.C. Elwood ◽  
K.M. Phillips ◽  
N. Lowe ◽  
J.K. Phillips ◽  
C. Toothill
Keyword(s):  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
Hard Water ◽  
Control Area ◽  
Blood Lead Levels ◽  
Domestic Water ◽  
Solvent Water ◽  
Small Rise ◽  
Lead Levels

1 The effect on the blood lead levels of residents in an area in which a soft plumbo-solvent water was hardened is examined. 2 Water lead levels fell after hardening was introduced whereas there was a small rise in water lead levels in a control area monitored over the same time. 3 The blood lead levels of residents fell after hardening and the fall was slightly greater than would have been predicted on the basis of the change in water lead levels. This suggests that lead is less well absorbed from hard water than from soft water. 4 Following hardening there was a significant fall in mean blood lead level of subjects living in houses which had initially had negligible amounts of lead in the water. This suggests that hard water may interfere with the absorption of lead from sources other than water.

INTERRELATIONSHIPS OF PITUITARY AND PLASMA CORTICOTROPHIN AND PLASMA CORTICOSTERONE IN ADRENALECTOMIZED AND STRESSED, ADRENALECTOMIZED RATS

1974 ◽  
Vol 63 (1) ◽  
pp. 213-222 ◽  
Author(s):  
JULIA C. BUCKINGHAM ◽  
J. R. HODGES
Keyword(s):  
Plasma Corticosterone ◽  
Prolonged Treatment ◽  
Delayed Effect ◽  
Plasma Acth ◽  
Corticosterone Concentration ◽  
Before And After ◽  
Small Rise ◽  
Acth Concentration ◽  
Corticosterone Treatment ◽  
Adrenalectomized Rats

SUMMARY Changes in pituitary and plasma corticotrophin (ACTH), estimated by redox bioassay, were correlated with changes in plasma corticosterone in adrenalectomized rats, with and without corticosterone treatment, before and after exposure to stress. After adrenalectomy, the plasma ACTH concentration was persistently increased. The pituitary ACTH content declined and then increased markedly. These changes were prevented by physiological doses of corticosteroids. Stress caused only a small rise in the plasma ACTH concentration in intact and sham-operated rats but a marked increase in adrenalectomized animals. This exaggerated response was reduced to normal by physiological doses of corticosterone. Prolonged treatment with higher doses of corticosterone was necessary to abolish completely the adrenocorticotrophic response to stress. However, one injection of the steroid, in a dose sufficient to raise the plasma corticosterone concentration to a similar level, did not impair the stress-induced release of ACTH. The results suggest that the synthesis and the basal release of ACTH are directly controlled by the concentration of corticosteroid in the blood, but the corticosteroids exert only a delayed effect in modulating the stress-induced release of the hormone.

scholarly journals Failure to collectively assess security surveillance technologies will inevitably lead to an absolute surveillance society.

2013 ◽  
Vol 12 (1) ◽  
pp. 73-88 ◽  
Author(s):  
Timothy Mitchener-Nissen
Keyword(s):  
New Technology ◽  
Security Technology ◽  
Security Technologies ◽  
Small Rise ◽  
The Absolute ◽  
Waking Up ◽  
Surveillance Society ◽  
The Individual ◽  
Security Surveillance ◽  
The Impact

When assessing any security technology which impacts upon privacy, whether this constitutes a new technology or the novel application of existing technologies, we should do so by examining the combined effect of all security interventions currently employed within a society. This contrasts with the prevailing system whereby the impact of a new security technology is predominantly assessed on an individual basis by a subjective balancing of the security benefits of that technology against any reductions in concomitant rights, such as privacy and liberty. I contend that by continuing to focus on the individual effect, as opposed to the combined effects, of security technologies within a society the likelihood of sleep-walking into (or indeed waking-up in) an absolute surveillance society moves from a possible future to the logically inevitable future. This conclusion is based on two underlying assertions. Firstly that assessing a technology often entails a judgement of whether any loss in privacy is legitimised by a justifiable increase in security; however one fundamental difference between these two rights is that privacy is a finite resource with identifiable end-states (i.e. absolute privacy through to the absolute absence of privacy) whereas security does not have two finite end-states (while there exists the absolute absence of security, absolute security is an unobtainable yet desired goal). The second assertion, which relies upon the validity of the first, holds that one consequence of absolute security being unobtainable yet desirable is that new security interventions will continuously be developed, each potentially trading a small measure of privacy for a small rise in security. Examined individually each intervention may constitute a justifiable trade-off. However this approach of combining interventions in the search for ever greater security will ultimately reduce privacy to zero.

scholarly journals Titus Phase Archeology at the S. Stockade Site (41TT865) on Tankersley Creek, Titus County, Texas

2003 ◽  
Author(s):  
Timothy K. Perttula ◽  
Bo Nelson ◽  
LeeAnna Schniebs
Keyword(s):  
Department Of Transportation ◽  
The West ◽  
Standing Water ◽  
Texas Department ◽  
Small Rise ◽  
Dense Concentration

The S. Stockade site was discovered on a small rise (330 feet amsl) in the Tankersley Creek floodplain during a recent archeological survey for the Texas Department of Transportation. Tankersley Creek is a southward-flowing tributary to Big Cypress Creek, and enters that creek’s floodplain a few miles below the Lake Bob Sandlin dam. There is a dense concentration of prehistoric archeological sites throughout the Tankersley Creek valley, particularly post-A.D. 800 Caddo Indian sites. This paper discusses the archeology of the S. Stockade site, a Late Caddoan Titus phase settlement. The rise at the S. Stockade site is grass-covered (with a surface visibility of less than 10%), except along the eroded slopes, where the clay B-horizon subsoil is exposed. The old creek channel immediately to the west of the rise has recently been channelized, and between the rise and the channelized creek are several low-lying marshy areas with standing water.

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