scholarly journals Protein kinase C isoenzymes: a review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis

2000 ◽  
Vol 130 (7) ◽  
pp. 1433-1452 ◽  
Author(s):  
Benjamin L J Webb ◽  
Stuart J Hirst ◽  
Mark A Giembycz
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Muscle Tone ◽  
Smooth Muscle Tone ◽  
Kinase C ◽  
Airways Smooth Muscle ◽  
Structure Regulation

Mechanisms of smooth muscle contraction

1996 ◽  
Vol 76 (4) ◽  
pp. 967-1003 ◽  
Author(s):  
A. Horowitz ◽  
C. B. Menice ◽  
R. Laporte ◽  
K. G. Morgan
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Striated Muscle ◽  
Muscle Tone ◽  
Contractile Activity ◽  
Covalent Modification ◽  
Smooth Muscle Tissue ◽  
Initial Development ◽  
Kinase C

Work performed with differentiated contractile smooth muscle tissue over the last two decades has made clear that covalent modification of myosin by phosphorylation of the 20-kDa myosin light chains is a significant mode of regulation of contractile activity in smooth muscle, particularly in regard to the generation of phasic contractions and the initial development of tonic contractions. This regulatory mechanism appears to be of unique importance in smooth muscle compared with striated muscle. It is equally clear, however, that there is an important role for protein kinase C in the regulation of smooth muscle tone maintenance, particularly in vascular smooth muscle. Several possible signal transduction cascades involving protein kinase C are outlined. Increasing evidence suggests a link between protein kinase C and actin-based regulatory mechanisms. This review places emphasis on relating up-to-date biochemical facts to the physiological realities of the smooth muscle cell.

Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level

1997 ◽  
Vol 54 (1) ◽  
pp. 199-205 ◽  
Author(s):  
Benjamin L.J. Webb ◽  
Mark A. Lindsay ◽  
Joachim Seybold ◽  
Nigel J. Brand ◽  
Magdi H. Yacoub ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Human Lung ◽  
Mrna Level ◽  
Kinase C ◽  
Airways Smooth Muscle

Regulation of Scavenger Receptor Expression in Smooth Muscle Cells by Protein Kinase C

1997 ◽  
Vol 17 (5) ◽  
pp. 969-978 ◽  
Author(s):  
Michele Mietus-Snyder ◽  
Annabelle Friera ◽  
Christopher K. Glass ◽  
Robert E. Pitas
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Smooth Muscle Cells ◽  
Scavenger Receptor ◽  
Muscle Cells ◽  
Receptor Expression ◽  
Kinase C

Antiproliferative action of protein kinase C in cultured rabbit aortic smooth muscle cells

1987 ◽  
Vol 173 (2) ◽  
pp. 504-514 ◽  
Author(s):  
Ken-Ichi Kariya ◽  
Yasuo Fukumoto ◽  
Terutaka Tsuda ◽  
Takeshi Yamamoto ◽  
Yasuhiro Kawahara ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Kinase C ◽  
Antiproliferative Action
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