scholarly journals Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene-related peptide induced dilation of dural meningeal vessels

2002 ◽  
Vol 137 (1) ◽  
pp. 62-68 ◽  
Author(s):  
S Akerman ◽  
D J Williamson ◽  
H Kaube ◽  
P J Goadsby
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Calcitonin Gene Related Peptide ◽  
Nitric Oxide Synthase Inhibitors ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Oxide Synthase

Nitric oxide synthase, calcitonin gene-related peptide and NK-1 receptor mechanisms are involved in GTN-induced neuronal activation

Cephalalgia ◽  
2013 ◽  
Vol 34 (2) ◽  
pp. 136-147 ◽  
Author(s):  
Roshni Ramachandran ◽  
Deepak Kumar Bhatt ◽  
Kenneth Beri Ploug ◽  
Anders Hay-Schmidt ◽  
Inger Jansen-Olesen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Femoral Vein ◽  
Calcitonin Gene Related Peptide ◽  
Human Model ◽  
Neuronal Activation ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Pre Treatment ◽  
Oxide Synthase

Background and aim Infusion of glyceryltrinitrate (GTN), a nitric oxide (NO) donor, in awake, freely moving rats closely mimics a universally accepted human model of migraine and responds to sumatriptan treatment. Here we analyse the effect of nitric oxide synthase (NOS) and calcitonin gene-related peptide (CGRP) systems on the GTN-induced neuronal activation in this model. Materials and methods The femoral vein was catheterised in rats and GTN was infused (4 µg/kg/min, for 20 minutes, intravenously). Immunohistochemistry was performed to analyse Fos, nNOS and CGRP and Western blot for measuring nNOS protein expression. The effect of olcegepant, L-nitro-arginine methyl ester (L-NAME) and neurokinin (NK)-1 receptor antagonist L-733060 were analysed on Fos activation. Results GTN-treated rats showed a significant increase of nNOS and CGRP in dura mater and CGRP in the trigeminal nucleus caudalis (TNC). Upregulation of Fos was observed in TNC four hours after the infusion. This activation was inhibited by pre-treatment with olcegepant. Pre-treatment with L-NAME and L-733060 also significantly inhibited GTN induced Fos expression. Conclusion The present study indicates that blockers of CGRP, NOS and NK-1 receptors all inhibit GTN induced Fos activation. These findings also predict that pre-treatment with olcegepant may be a better option than post-treatment to study its inhibitory effect in GTN migraine models.

scholarly journals Nitric oxide synthase activity in rat gastric mucosa contributes to mucin synthesis elicited by calcitonin gene-related peptide

2006 ◽  
Vol 27 (3) ◽  
pp. 117-124 ◽  
Author(s):  
Takafumi ICHIKAWA ◽  
Tatsumi KUSAKABE ◽  
Yukari GONO ◽  
Nobuaki SHIKAMA ◽  
Hiromi HIRUMA ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Gastric Mucosa ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Mucin Synthesis ◽  
Calcitonin Gene ◽  
Rat Gastric Mucosa ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

THE EFFECTS OF BLOCKING CALCITONIN GENE RELATED PEPTIDE AND NITRIC OXIDE SYNTHASE IN A RAT MODEL OF ENDOTOXIC SHOCK

Shock ◽  
1995 ◽  
Vol 3 ◽  
pp. 50
Author(s):  
C. Ezeugwu ◽  
E. Hannon ◽  
T. Savel ◽  
D. Kreisel ◽  
A. Manasia ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Rat Model ◽  
Endotoxic Shock ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Oxide Synthase

THE EFFECTS OF BLOCKING CALCITONIN GENE RELATED PEPTIDE, and NITRIC OXIDE SYNTHASE IN A RAT MODEL OF ENDOTOXIC SHOCK

Shock ◽  
1995 ◽  
Vol 3 (6) ◽  
pp. 50
Author(s):  
C. Ezeugwu ◽  
E. Hannon ◽  
T. Savel ◽  
D. Kreisel ◽  
A. Manasia ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Rat Model ◽  
Endotoxic Shock ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Oxide Synthase

Levels of Endothelial Nitric Oxide Synthase and Calcitonin Gene–related Peptide in the Charcot Foot: A Pilot Study

2008 ◽  
Vol 47 (5) ◽  
pp. 424-429 ◽  
Author(s):  
Javier La Fontaine ◽  
Lawrence B. Harkless ◽  
Victor L. Sylvia ◽  
David Carnes ◽  
Josefine Heim-Hall ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pilot Study ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Calcitonin Gene Related Peptide ◽  
Charcot Foot ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide
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