scholarly journals Plasma insulin, cholecystokinin, galanin, neuropeptide Y and leptin levels in obese women with and without type 2 diabetes mellitus

2000 ◽  
Vol 24 (S2) ◽  
pp. S152-S152 ◽  
Author(s):  
A Milewicz ◽  
E Mikulski ◽  
B Bidzińska
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Neuropeptide Y ◽  
Plasma Insulin ◽  
Obese Women

scholarly journals Lipocalin-2 expression and serum levels as early predictors of type 2 diabetes mellitus in obese women

IUBMB Life ◽  
2017 ◽  
Vol 69 (2) ◽  
pp. 88-97 ◽  
Author(s):  
Nearmeen M. Rashad ◽  
Amal S. El-Shal ◽  
Rasha L. Etewa ◽  
Fady M. Wadea
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Levels ◽  
Lipocalin 2 ◽  
Obese Women ◽  
Early Predictors

scholarly journals Elevated plasma levels of SPARC in patients with newly diagnosed type 2 diabetes mellitus

2011 ◽  
Vol 165 (4) ◽  
pp. 597-601 ◽  
Author(s):  
Dandong Wu ◽  
Ling Li ◽  
Mengliu Yang ◽  
Hua Liu ◽  
Gangyi Yang
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Plasma Insulin ◽  
Normal Subjects ◽  
Model Assessment ◽  
Newly Diagnosed ◽  
Affecting Factors ◽  
Metabolic Conditions

ObjectiveSecreted protein acidic and rich in cysteine (SPARC) also known as BM-40 which has been studied in various pathological conditions, has recently been suggested as a key player in the pathology of obesity and type 2 diabetes mellitus (T2DM). However, there are few studies on putative pathophysiologic roles of SPARC in glucose metabolism. The aim of this study was to determine whether plasma SPARC concentrations were altered in subjects with different glucose metabolic conditions and to investigate the affecting factors.Design and methodsIn this study, 54 newly diagnosed T2DM subjects, 53 subjects with impaired glucose regulation (IGR), and 53 normal subjects (body mass index (BMI): 24.98±3.75 vs 24.70±2.78 and 24.53±3.66 kg/m2, P>0.05) were enrolled. Plasma SPARC levels were measured with an ELISA under overnight fasting conditions. The relationships between plasma SPARC and several metabolic factors, such as BMI, blood lipids, blood glucose, plasma insulin levels, and other factors were also assessed.ResultsSPARC levels were higher in subjects with T2DM compared with IGR and control subjects (16.74±6.99 vs 14.04±8.03 μg/l, P<0.05 and 16.74±6.99 vs 11.72±4.47 μg/l, P<0.01). However, there was no difference in plasma SPARC levels between IGR subjects and the controls. Plasma SPARC levels correlated positively with BMI, the percentage of fat, triglyceride, fasting plasma insulin, 2 h plasma insulin after a glucose load, and the homeostasis model assessment of insulin resistance in simple regression analysis.ConclusionThe present work indicates a potential link between SPARC and the pathogenesis of T2DM.

Polymorphisms rs144723656, rs2268574, and rs2268575 of the glucokinase gene are not associated with obese women with type 2 diabetes mellitus

2016 ◽  
Vol 49 (1-2) ◽  
pp. 194-195
Author(s):  
Henrique Ravanhol Frigeri ◽  
Nathalia Cavalheiro Auwerter ◽  
Letícia Koczicki ◽  
Laysa Toschi Martins ◽  
Emanuel Maltempi de Souza ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Obese Women ◽  
Glucokinase Gene

scholarly journals Osteoprotegerin Expression and Serum Values in Obese Women with Type 2 Diabetes Mellitus

2021 ◽  
Author(s):  
Nearmeen M. Rashad ◽  
Amal S. El-Shal ◽  
Sally M Shalaby ◽  
Walaa M Sarhan ◽  
Hanim M. Abdel-Nour
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Levels ◽  
Obese Patients ◽  
Obese Women ◽  
Expression Levels ◽  
Obesity And Diabetes

Abstract Obesity and diabetes prevalence are increasing worldwide. We aimed by this work to detect the possible association of osteoprotegerin (OPG) gene expression with visceral adiposity indices and cardiometabolic risk factors among obese patients. This is research enrolled 150 controls and 150 obese cases subdivided into two subgroups non-diabetic (n = 70) and 80 patients with type 2 diabetes mellitus (T2DM). Circulating OPG expression levels were determined by RT-PCR. Serum OPG concentrations were assessed by ELISA.Our results explored that OPG serum levels were higher in the control group compared to obese women and obese diabetics had higher serum levels of OPG in comparison to obese non-diabetic patients. In obese group, regarding expression levels of OPG were higher than controls in diabetic obese patients, the blood expression levels of OPG were higher than non-diabetics patients. We found positive correlations between parameters of MetS and obesity indices, among them, the highest positive correlation found between VAI. After adjustment of the traditional risk factors, stepwise linear regression analysis test revealed that, OPG expression levels were independently correlated with HbA1c, HDL-cholesterol, and WHR. ROC analysis demonstrated that cutoff values of OPG expression levels and serum levels were 2.226 and 7.5; the AUC were 0.833 (95% CI = 0.821–0.946) and 0.981, respectively. Additionally, the sensitivities and the specificities of OPG expression were (90% and 86.2%), and OPG serum levels (98% and %94), respectively.OPG mRNA and serum levels are useful diagnostic biomarkers discriminate metabolic risk among obesity with or without T2DM.

scholarly journals Increased serum concentrations of macrophage inhibitory cytokine-1 in patients with obesity and type 2 diabetes mellitus: the influence of very low calorie diet

2009 ◽  
Vol 161 (3) ◽  
pp. 397-404 ◽  
Author(s):  
Ivana Dostálová ◽  
Tomáš Roubíček ◽  
Markéta Bártlová ◽  
Miloš Mráz ◽  
Zdena Lacinová ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mrna Expression ◽  
Obese Women ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet

ObjectiveMacrophage inhibitory cytokine-1 (MIC-1) is a novel regulator of energy homeostasis. We explored whether alterations in MIC-1 levels contribute to metabolic disturbances in patients with obesity and/or obesity and type 2 diabetes mellitus (T2DM).DesignWe measured serum MIC-1 levels and its mRNA expression in subcutaneous and visceral adipose tissue of 17 obese nondiabetic women, 14 obese women with T2DM and 23 healthy lean women. We also explored the relationship of MIC-1 with anthropometric and biochemical parameters and studied the influence of 2-week very low calorie diet (VLCD) on serum MIC-1 levels.MethodsSerum MIC-1 levels were measured by ELISA and its mRNA expression was determined by RT-PCR.ResultsBoth obese and T2DM group had significantly elevated serum MIC-1 levels relative to controls. T2DM group had significantly higher serum MIC-1 levels relative to obese group. Serum MIC-1 positively correlated with body weight, body fat, and serum levels of triglycerides, glucose, HbAlc, and C-reactive protein and it was inversely related to serum high-density lipoprotein cholesterol. Fat mRNA MIC-1 expression did not significantly differ between lean and obese women but it was significantly higher in subcutaneous than in visceral fat in both groups. VLCD significantly increased serum MIC-1 levels in obese but not T2DM group.ConclusionElevated MIC-1 levels in patients with obesity are further increased by the presence of T2DM. We suggest that in contrast to patients with cancer cachexia, increased MIC-1 levels in obese patients and diabetic patients do not induce weight loss.

scholarly journals To Compare the Anti-Inflammatory Effect of Oral Hypoglycemic Drugs in Type 2 Diabetes Mellitus

2018 ◽  
Vol 11 (3) ◽  
pp. 1667-1674
Author(s):  
A. Umamaheswari ◽  
K. Bhuvaneswari ◽  
R. Senthilkumar
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Plasma Insulin ◽  
Hypoglycemic Agents ◽  
Care Hospital ◽  
Anti Inflammatory

Insulin resistance and endothelial dysfunction which shares multiple signaling pathways like hyperinsulinemia, glucotoxicity and inflammation in type 2 Diabetes Mellitus (DM) leads to several micro and macrovascular complications. Studies have shown the anti-inflammatory effects of certain oral hypoglycemic agents which will be helpful in preventing the impact of diabetes related complications. The study aimed to compare the anti-inflammatory effects of Sitagliptin and Acarbose in combination with Metformin and Sulfonylurea in Type 2DM patients by using Anti-inflammatory markers Interleukin-6 (IL6), high sensitive C-reactive protein (hsCRP) and also to compare the clinical outcome between these two groups by using the parameters Fasting blood sugar (FBS), Post prandial blood sugar (PPBS), hemoglobin A1c (HbA1C), Plasma Insulin. In this open labeled prospective parallel group clinical study 30 type 2 diabetes patients on Metformin and Sulfonylurea combination, with HbA1c value ≥7.5 were recruited in tertiary care hospital and divided into two groups based on their HbA1C levels and were added on either Acarbose or Sitagliptin along with Metformin Sulfonylurea combinations and were followed for 3 months. Parameters like FBS, PPBS, HbA1c, Plasma Insulin hsCRP, IL-6were measured before and after the study. In the study the mean value of FBS, PPBS, HbA1c, Plasma Insulin, Insulin Resistance, hsCRP were reduced in both Sitagliptin and Acarbose group, which were similar to the results of previous studies except IL6 which got reduced in Sitagliptin group but increased in Acarbose group. The study had showed the synergism of Sitagliptin with Metform in Sulfonylurea combinationin reducing inflammation however; still long term studies are required to confirm their anti-inflammatory effects.

scholarly journals Leptin levels in obese women with and without type 2 diabetes mellitus

2004 ◽  
Vol 13 (5-6) ◽  
pp. 321-325 ◽  
Author(s):  
Mehmet Akif Buyukbese ◽  
Ali Cetinkaya ◽  
Ramazan Kocabas ◽  
Aytekin Guven ◽  
Mehmet Tarakcioglu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Density Lipoprotein ◽  
The Body ◽  
Obese Women ◽  
Diabetes Mellitus Group ◽  
Group 2 ◽  
Group 1

INTRODUCTION: The role of leptin has been more clear in the endocrinology area after the discovery of its secretion from the adipose tissue. The aim of the study is to investigate the leptin levels in obese women in whom type 2 diabetes mellitus were present or absent.Materials and methods: Thirty-five obese women with type 2 diabetes mellitus (group 1) and 34 obese women without type 2 diabetes mellitus (group 2) were enrolled in the study. In both groups the body mass index (BMI), waist circumference, and waist-to-hip ratio were measured. Leptin, HbA1c, creatinine and the lipid profile were assessed.Results: Leptin was found to be statistically significantly lower in group 1 than in group 2 (40.22±17.77 ng/ml versus 50.12±15.51 ng/ml, respectively;p=0.019). It was well correlated with BMI in group 1 (r=0.60,p=0.0001). In group 1 also, correlation of leptin was moderate with creatinine and high-density lipoprotein-cholesterol (r=0.36,p=0.037versusr=0.37,p=0.027, respectively), whereas triglyceride had a negative correlation (r=-0.34,p=0.046). In group 2, the only significant correlation with leptin was BMI (r=0.41,p=0.02). Leptin was also significantly lower in 17 subjects with poorly controlled diabetes mellitus than in 18 well-controlled diabetics (33.54±15.82 ng/ml versus 44.61±17.54 ng/ml, respectively;p=0.038).Conclusion: Since leptin is lower in obese women with diabetes than without diabetes and additionally it is even lower in the poorly controlled diabetes subgroup, we think that further studies are required to make clear the issue for lower leptin levels, whether it is a reason or an outcome.

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