Beyond biocompatibility: an approach for the synthesis of ZnS quantum dot-chitosan nano-immunoconjugates for cancer diagnosis

2015 ◽  
Vol 17 (3) ◽  
pp. 1820-1830 ◽  
Author(s):  
Herman S. Mansur ◽  
Alexandra A. P. Mansur ◽  
Amanda Soriano-Araújo ◽  
Zélia I. P. Lobato
Keyword(s):  
Green Chemistry ◽  
Quantum Dot ◽  
Cancer Cells ◽  
Cancer Diagnosis ◽  
Environmentally Friendly

Nanomedicine meets green chemistry: Biocompatible ZnS-immunoconjugates were developed to detectin vitroNHL cancer cells using an environmentally-friendly aqueous process.

Dual-functional supramolecular nanohybrids of quantum dot/biopolymer/chemotherapeutic drug for bioimaging and killing brain cancer cells in vitro

2019 ◽  
Vol 184 ◽  
pp. 110507 ◽  
Author(s):  
Alexandra A.P. Mansur ◽  
Anderson J. Caires ◽  
Sandhra M. Carvalho ◽  
Nadia S.V. Capanema ◽  
Isadora C. Carvalho ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Cancer Cells ◽  
Brain Cancer ◽  
Chemotherapeutic Drug ◽  
Dual Functional

The use of L-glucose in cancer diagnosis: Results from In Vitro and In Vivo Studies

2021 ◽  
Vol 28 ◽  
Author(s):  
Ioanna A. Anastasiou ◽  
Ioanna Eleftheriadou ◽  
Anastasios Tentolouris ◽  
Iordanis Mourouzis ◽  
Constantinos Pantos ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Diagnosis ◽  
English Language ◽  
Research Work ◽  
Tumor Development ◽  
Mirror Image ◽  
In Vivo Studies ◽  
Cochrane Library

Background:: Cancer cells are characterized by metabolic heterogeneity. Although many research groups make efforts to analyze this heterogeneity, little attention has been paid to the scenario that cancer cells may utilize otherwise unusable substrates as fuel for tumor development. Of the two stereoisomers of glucose, D-glucose but not L-glucose, the mirror image isomer of D-glucose, is abundantly found in nature. D-glucose is the human body's key source of energy, through aerobic respiration. However, data from in vitro and in vivo studies examining the ability of cancer cells to take up L-glucose are scarce. Objectives: The present mini-review aims to present current literature data on the role of L-glucose in cancer diagnosis based on in vitro and in vivo studies. Methods: The MEDLINE, EMBASE, and the Cochrane Library with restrictions to articles in English language databases were searched to retrieve available data. Results: There are limited data in literature regarding in vitro and in vivo studies that examined the ability of cancer cells to take up L-glucose. Research work so far has shown that that the binding of a fluorescent detector to L-glucose molecule produced a fluorescent probe that was specifically taken up by malignant cancer cells, thus providing a unique method for their detection. Conclusion: Given that L-glucose is taken up by cancer cells, L-glucose fluorescent probes can be a useful tool for visualization and characterization of cancer cells. More research on the potential biologic effects of L-glucose in cancer is necessary.

Bi-functional quantum dot-polysaccharide-antibody immunoconjugates for bioimaging and killing brain cancer cells in vitro

2019 ◽  
Vol 252 ◽  
pp. 333-337 ◽  
Author(s):  
Cleildo P. Santana ◽  
Alexandra A.P. Mansur ◽  
Sandhra M. Carvalho ◽  
Armando da Silva-Cunha ◽  
Herman S. Mansur
Keyword(s):  
Quantum Dot ◽  
Cancer Cells ◽  
Brain Cancer ◽  
Polysaccharide Antibody

Water-soluble nanoconjugates of quantum dot-chitosan-antibody for in vitro detection of cancer cells based on “enzyme-free” fluoroimmunoassay

2015 ◽  
Vol 52 ◽  
pp. 61-71 ◽  
Author(s):  
Herman S. Mansur ◽  
Alexandra A.P. Mansur ◽  
Amanda Soriano-Araújo ◽  
Zélia I.P. Lobato ◽  
Sandhra M. de Carvalho ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Cancer Cells ◽  
Water Soluble

scholarly journals L-cysteine and poly-L-arginine grafted carboxymethyl cellulose/Ag-In-S quantum dot fluorescent nanohybrids for in vitro bioimaging of brain cancer cells

2019 ◽  
Vol 133 ◽  
pp. 739-753 ◽  
Author(s):  
Isadora C. Carvalho ◽  
Alexandra A.P. Mansur ◽  
Sandhra M. Carvalho ◽  
Rodrigo M. Florentino ◽  
Herman S. Mansur
Keyword(s):  
Quantum Dot ◽  
Cancer Cells ◽  
Brain Cancer ◽  
Carboxymethyl Cellulose

Cytotoxic effects of disulfiram and synergism with cisplatin on ovarian cancer cells in vitro

2018 ◽  
Author(s):  
F Guo ◽  
Z Yang ◽  
J Xu ◽  
J Sehouli ◽  
AE Albers ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Cytotoxic Effects

Cytotoxic Effect of the Combination of Gemcitabine and Atorvastatin Loaded in Microemulsion on the HCT116 Colon Cancer Cells

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Mayson H. Alkhatib ◽  
Dalal Al-Saedi ◽  
Wadiah S. Backer
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Therapeutic Potential ◽  
Morphological Changes ◽  
In Vitro Study ◽  
Colon Cancer Cells ◽  
Apoptosis Detection ◽  
Hct116 Cells

The combination of anticancer drugs in nanoparticles has great potential as a promising strategy to maximize efficacies by eradicating resistant, reduce the dosage of the drug and minimize toxicities on the normal cells. Gemcitabine (GEM), a nucleoside analogue, and atorvastatin (ATV), a cholesterol lowering agent, have shown anticancer effect with some limitations. The objective of this in vitro study was to evaluate the antitumor activity of the combination therapy of GEM and ATVencapsulated in a microemulsion (ME) formulation in the HCT116 colon cancer cells. The cytotoxicity and efficacy of the formulation were assessed by the 3- (4,5dimethylthiazole-2-yl)-2,5-diphyneltetrazolium bromide (MTT) assay. The mechanism of cell death was examined by observing the morphological changes of treated cells under light microscope, identifying apoptosis by using the ApopNexin apoptosis detection kit, and viewing the morphological changes in the chromatin structure stained with 4′,6-diamidino-2-phenylindole (DAPI) under the inverted fluorescence microscope. It has been found that reducing the concentration of GEM loaded on ME (GEM-ME) from 5μM to 1.67μM by combining it with 3.33μM of ATV in a ME formulation (GEM/2ATV-ME) has preserved the strong cytotoxicity of GEM-ME against HCT116 cells. The current study proved that formulating GEM with ATV in ME has improved the therapeutic potential of GEM and ATV as anticancer drugs.

N-hexane Extract and Fraction of Green Tea as Antiproliferation of MCM-B2 Breast Cancer Cells In Vitro

2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Lisni Noraida Waruwu ◽  
Maria Bintang ◽  
Bambang Pontjo Priosoeryanto
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Green Tea ◽  
Cancer Cell ◽  
Breast Cancer Cells ◽  
Green Tea Extract ◽  
Hexane Fraction ◽  
Phytochemical Screening ◽  
Tea Extract

Green tea (Camellia sinensis) is one of traditional plants that have the potential as an anticancer. The sample used in this research commercial green tea extract. The purpose of this study was to test the antiproliferation activity of green tea extract on breast cancer cell MCM-B2 in vitro. Green tea extract fractionated using three solvents, ie water, ethanol 70%, and n-hexane. Extract and fraction of green tea water have value Lethality Concentration 50 (LC50) more than 1000 ppm. The fraction of ethanol 70% and n-hexane had an LC50 value of 883.48 ppm and 600.56 ppm, respectively. The results of the phytochemical screening of green tea extract are flavonoids, tannins, and saponins, while the phytochemical screening results of n-hexane fraction are flavonoids and tannins. Antiproliferation activity was tested on breast cancer cells MCM-B2 and normal cells Vero by trypan blue staining method. The highest MCM-B2 cell inhibitory activity was achieved at a concentration of 13000 ppm green tea extract and 1000 ppm of n-hexane fraction, 59% and 59%, respectively. The extract and n-hexane fraction of green tea are not toxic to normal Vero cells characterized by not inhibiting normal cell proliferation. Keywords: antiproliferative, cancer cell MCM-B2, commercial green tea, cytotoxicity

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