Application of a quinone-based fluorophore for spectrofluorimetric determination of albendazole in pure form and pharmaceutical formulations

2016 ◽  
Vol 8 (25) ◽  
pp. 5136-5141 ◽  
Author(s):  
Khalid A. M. Attia ◽  
Ahmad A. Mohamad ◽  
Mohamed S. Emara
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Pharmaceutical Formulations ◽  
Pure Form ◽  
Spectrofluorimetric Method ◽  
Spectrofluorimetric Determination ◽  
Ct Complex

A spectrofluorimetric method was developed for the determination of albendazole (ALB) through charge transfer (CT) complex formation with 7,7,8,8-tetracyanoquinodimethane (TCNQ).

scholarly journals Spectrophotometric determination of cefixime by charge transfer complex formation

2013 ◽  
Vol 10 (3) ◽  
pp. 971-976
Author(s):  
Baghdad Science Journal
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Spectrophotometric Determination ◽  
Electron Donor ◽  
Charge Transfer Complex ◽  
Pure Form ◽  
Colored Complex ◽  
Spectrophotometric Methods ◽  
Beer’S Law

Simple, sensitive and economical spectrophotometric methods have been developed for the determination of cefixime in pure form. This method is based on the reaction of cefixime as n-electron donor with chloranil to give highly colored complex in ethanol which is absorb maximally at 550 nm. Beer's law is obeyed in the concentration ranges 5-250 µg ml-1 with high apparent molar absorptivities of 1.52×103 L.mole-1. cm-1.

scholarly journals Spectrphotometric Determination of Buclizine as Hydrochloride Using Various Chromogenic Reagents

2010 ◽  
Vol 7 (4) ◽  
pp. 1523-1529
Author(s):  
V. Annapurna ◽  
G. Jyothi ◽  
A. V. Subbayamma ◽  
B. B. V. Sailaja
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Charge Transfer Complex ◽  
Hydroxylamine Hydrochloride ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Method Of Least Squares ◽  
Spectrophotometric Methods ◽  
Formation Method

Simple, accurate and reproducible UV spectrophotometric methods were established for the assay ofbuclizine(BUCZ) based on the formation of precipitation, charge transfer complex and inner complex formation. Method A involves the precipitation, charge transfer complex formation of BUCZ with tannic acid/p-N-methyl aminophenol sulphate (PMAP)-Cr(VI), the complex formation with cobalt thiocyanate (CTC) in method B and inner complex formation of BUCZ with sodium nitroprusside hydroxylamine hydrochloride and sodium carbonate in method C were proposed. The optical characteristics such as Beers law limits, molar absorptivity and Sandell’s sensitivity for the methods (A-C) are given. Regression analysis using the method of least squares was made to evaluate the slope(b), intercept(a) and correlation coefficient (r) and standard error of estimation (Se) for each system Determination of BUCZ in bulk form and in pharmaceutical formulations were also incorporated.

scholarly journals Studying the association complex formation of atomoxetine and fluvoxamine with eosin Y and its application in their fluorimetric determination

2018 ◽  
Vol 5 (3) ◽  
pp. 170943 ◽  
Author(s):  
Sayed M. Derayea ◽  
Mahmoud A. Omar ◽  
Ahmed A. Abu-hassan
Keyword(s):  
Complex Formation ◽  
Pharmaceutical Formulations ◽  
Eosin Y ◽  
Fluorimetric Determination ◽  
Pharmaceutical Dosage Forms ◽  
Average Percentage ◽  
Binary Complexes ◽  
Spectrofluorimetric Method ◽  
Optimum Reaction

A simple, sensitive and non-extractive spectrofluorimetric method has been developed and validated for the determination of two psychoanaleptic drugs, atomoxetine and fluvoxamine, in pure forms and pharmaceutical dosage forms. The proposed method is based on the formation of binary complexes between eosin Y and the studied drugs in the presence of a Teorell–Stenhagen buffer. The quenching of the native fluorescence of eosin Y due to complex formation with the studied drugs was measured spectrofluorimetrically at 545 nm after excitation at 302 nm. At the optimum reaction conditions, the fluorescence quenching values (Δ F ) and concentrations were rectilinear over the concentration ranges of 0.2–2.2 and 0.3–2.2 µg ml −1 for atomoxetine and fluvoxamine, respectively. The developed method was successfully applied for the determination of the studied drugs in their pharmaceutical formulations with average percentage recoveries of 100.13 ± 0.66 and 99.69 ± 0.44 for atomoxetine and fluvoxamine, respectively ( n  = 5), without interference from common excipients.

Sign in / Sign up

Export Citation Format

Share Document