Synthesis, relaxation properties and in vivo assessment of a carborane-GdDOTA-monoamide conjugate as an MRI blood pool contrast agent

2015 ◽  
Vol 13 (33) ◽  
pp. 8912-8918 ◽  
Author(s):  
Lalit N. Goswami ◽  
Quanyu Cai ◽  
Lixin Ma ◽  
Satish S. Jalisatgi ◽  
M. Frederick Hawthorne
Keyword(s):  
Contrast Agent ◽  
Blood Pool ◽  
Blood Pool Contrast Agent ◽  
Relaxation Properties ◽  
High Relaxivity ◽  
In Vivo Assessment

The synthesis, relaxivity measurements and in vivo assessment of CB-GdDOTA-MA amphiphilic conjugate as blood pool contrast agent (BPCA) is reported. This BPCA showed high relaxivity (r1 = 6.8 mM−1 s−1 at 7 T in PBS) and exhibited excellent binding (87.4%) with HSA.

scholarly journals Ultra High-Resolution In vivo Computed Tomography Imaging of Mouse Cerebrovasculature Using a Long Circulating Blood Pool Contrast Agent

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Zbigniew Starosolski ◽  
Carlos A. Villamizar ◽  
David Rendon ◽  
Michael J. Paldino ◽  
Dianna M. Milewicz ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Contrast Agent ◽  
Blood Pool ◽  
Computed Tomography Imaging ◽  
Blood Pool Contrast Agent ◽  
Tomography Imaging

scholarly journals Amphiphilic DTPA Multimer Assembled on Icosahedral Closo-Borane Motif as High-Performance MRI Blood Pool Contrast Agent

2021 ◽  
Author(s):  
Lalit N. Goswami ◽  
Shatadru Chakravarty ◽  
Quan-Yu Cai ◽  
Erik M. Shapiro ◽  
M. Frederick Hawthorne ◽  
...  
Keyword(s):  
Contrast Agent ◽  
High Performance ◽  
Blood Pool ◽  
Blood Pool Contrast Agent

High-Spatial-Resolution Multistation MR Angiography with Parallel Imaging and Blood Pool Contrast Agent: Initial Experience

Radiology ◽  
2006 ◽  
Vol 241 (3) ◽  
pp. 861-872 ◽  
Author(s):  
Konstantin Nikolaou ◽  
Harald Kramer ◽  
Christina Grosse ◽  
Dirk Clevert ◽  
Olaf Dietrich ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Spatial Resolution ◽  
Mr Angiography ◽  
Parallel Imaging ◽  
High Spatial Resolution ◽  
Blood Pool ◽  
Initial Experience ◽  
Blood Pool Contrast Agent

scholarly journals In Vivo Quantification of Myocardial Infarction in Mice Using Micro-CT and a Novel Blood Pool Agent

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Stefan Sawall ◽  
Danielle Franke ◽  
Anne Kirchherr ◽  
Jan Beckendorf ◽  
Jan Kuntz ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Contrast Agent ◽  
Infarct Size ◽  
Blood Pool ◽  
Signal Enhancement ◽  
Imaging Method ◽  
Micro Ct ◽  
Contrast Agent Injection ◽  
Dependent Signal

We herein developed a micro-CT method using the innovative contrast agent ExiTron™ MyoC 8000 to longitudinally monitor cardiac processes in vivo in small animals. Experiments were performed on healthy mice and mice with myocardial infarction inflicted by ligation of the left anterior descending artery. Time-dependent signal enhancement in different tissues of healthy mice was measured and various contrast agent doses were investigated so as to determine the minimum required dose for imaging of the myocardium. Due to its ability to be taken up by healthy myocardium but not by infarct tissue, ExiTron MyoC 8000 enables detection of myocardial infarction even at a very low dose. The signal enhancement in the myocardium of infarcted mice after contrast agent injection was exploited for quantification of infarct size. The values of infarct size obtained from the imaging method were compared with those obtained from histology and showed a significant correlation (R2=0.98). Thus, the developed micro-CT method allows for monitoring of a variety of processes such as cardiac remodeling in longitudinal studies.

Self-Assembled Nanomicelles as MRI Blood-Pool Contrast Agent

2017 ◽  
Vol 24 (6) ◽  
pp. 1348-1357 ◽  
Author(s):  
Andrej Babič ◽  
Vassily Vorobiev ◽  
Céline Xayaphoummine ◽  
Gaëlle Lapicorey ◽  
Anne-Sophie Chauvin ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Blood Pool ◽  
Blood Pool Contrast Agent ◽  
Self Assembled

Pre-clinical evaluation of a nanoparticle-based blood-pool contrast agent for MR imaging of the placenta

Placenta ◽  
2017 ◽  
Vol 57 ◽  
pp. 60-70 ◽  
Author(s):  
Ketan B. Ghaghada ◽  
Zbigniew A. Starosolski ◽  
Saakshi Bhayana ◽  
Igor Stupin ◽  
Chandreshkumar V. Patel ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Clinical Evaluation ◽  
Blood Pool ◽  
Blood Pool Contrast Agent

MR Angiography of Aortoiliac Occlusive Disease: A Phase III Study of the Safety and Effectiveness of the Blood-Pool Contrast Agent MS-325

Radiology ◽  
2005 ◽  
Vol 236 (3) ◽  
pp. 825-833 ◽  
Author(s):  
Mathias Goyen ◽  
Mark Edelman ◽  
Pierre Perreault ◽  
Elaine O'Riordan ◽  
Hernan Bertoni ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mr Angiography ◽  
Blood Pool ◽  
Occlusive Disease ◽  
Phase Iii ◽  
Aortoiliac Occlusive Disease ◽  
Blood Pool Contrast Agent ◽  
Phase Iii Study

T 2- and T*2-weighted MRI of rat glioma using polysorbate-coated magnetic nanocrystals as a blood-pool contrast agent

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19708-19714 ◽  
Author(s):  
Young Han Lee ◽  
Dan Heo ◽  
Myeonghwan Hwang ◽  
Bongjune Kim ◽  
Soeckgu Kang ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Intravenous Injection ◽  
Blood Pool ◽  
Blood Pool Contrast Agent ◽  
Rat Glioma ◽  
Magnetic Nanocrystals ◽  
Glioma Model ◽  
3.0T Mri

In this study, T2- and T*2-weighted imaging potential of polysorbate-coated magnetic nanocrystals (P-MNCs) was investigated as a blood-pool contrast agent using a 9L-rat glioma model after intravenous injection via 3.0T MRI.

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