scholarly journals T- and B-cell immunosuppressive activity of novel α-santonin analogs with humoral and cellular immune response in Balb/c mice

MedChemComm ◽  
2017 ◽  
Vol 8 (1) ◽  
pp. 211-219 ◽  
Author(s):  
Nisar A. Dangroo ◽  
Jasvinder Singh ◽  
Nidhi Gupta ◽  
Shashank Singh ◽  
Anapurna Kaul ◽  
...  
Keyword(s):  
Immune Response ◽  
B Cell ◽  
Cellular Immunity ◽  
Cellular Immune Response ◽  
Immunosuppressive Activity ◽  
Humoral And Cellular Immunity ◽  
Cellular Immune

Herein we report the synthesis of α-santonin analogs, and identification of potent immunosuppressant molecules. In vivo investigation on BALB/c mice revealed that compound 4e suppresses both humoral and cellular immunity.

scholarly journals Cellular Immune Response Against Firefly Luciferase After Sleeping Beauty–Mediated Gene Transfer In Vivo

2014 ◽  
Vol 25 (11) ◽  
pp. 955-965 ◽  
Author(s):  
Kelly M. Podetz-Pedersen ◽  
Vaiva Vezys ◽  
Nikunj V. Somia ◽  
Stephen J. Russell ◽  
R. Scott McIvor
Keyword(s):  
Immune Response ◽  
Gene Transfer ◽  
Cellular Immune Response ◽  
Firefly Luciferase ◽  
Sleeping Beauty ◽  
Cellular Immune

scholarly journals Evidence of Long-Lasting Humoral and Cellular Immunity against SARS-CoV-2 Even in Elderly COVID-19 Convalescents Showing a Mild to Moderate Disease Progression

Life ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 805
Author(s):  
Bastian Fischer ◽  
Christopher Lindenkamp ◽  
Christoph Lichtenberg ◽  
Ingvild Birschmann ◽  
Cornelius Knabbe ◽  
...  
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Nucleocapsid Protein ◽  
Interferon Γ ◽  
Special Equipment ◽  
Humoral And Cellular Immunity ◽  
Moderate Disease ◽  
Ifn Γ ◽  
Blood Specimens ◽  
Cellular Immune

We here evaluate the humoral and cellular immune response against SARS-CoV-2 in 41 COVID-19 convalescents. As previous studies mostly included younger individuals, one advantage of our study is the comparatively high mean age of the convalescents included in the cohort considered (54 ± 8.4 years). While anti-SARS-CoV-2 antibodies were still detectable in 95% of convalescents up to 8 months post infection, an antibody-decay over time was generally observed in most donors. Using a multiplex assay, our data additionally reveal that most convalescents exhibit a broad humoral immunity against different viral epitopes. We demonstrate by flow cytometry that convalescent donors show a significantly elevated number of natural killer cells when compared to healthy controls, while no differences were found concerning other leucocyte subpopulations. We detected a specific long-lasting cellular immune response in convalescents by stimulating immune cells with SARS-CoV-2-specific peptides, covering domains of the viral spike, membrane and nucleocapsid protein, and measuring interferon-γ (IFN-γ) release thereafter. We modified a commercially available ELISA assay for IFN-γ determination in whole-blood specimens of COVID-19 convalescents. One advantage of this assay is that it does not require special equipment and can, thus, be performed in any standard laboratory. In conclusion, our study adds knowledge regarding the persistence of immunity of convalescents suffering from mild to moderate COVID-19. Moreover, our study provides a set of simple methods to characterize and confirm experienced COVID-19.

scholarly journals Modern Conceptions about the Mechanisms of Interaction Between Biofilm and Cellular Immunity Factors

2020 ◽  
Vol 97 (1) ◽  
pp. 83-90
Author(s):  
N. M. Shlepotina ◽  
M. V. Peshikova ◽  
O. L. Kolesnikov ◽  
Yu. S. Shishkova
Keyword(s):  
Immune Response ◽  
Pseudomonas Aeruginosa ◽  
Immune System ◽  
Cellular Immunity ◽  
Cellular Immune Response ◽  
Growth And Development ◽  
Microbial Consortium ◽  
Significant Negative Effect ◽  
Negative Effect ◽  
Cellular Immune

Features of the cellular immune response in the presence of a microbial biofilm are well described in the literature. Based on numerous studies, it became possible to establish a number of patterns: mature biofilms are better protected from immune factors, the effectiveness of antibiofilm strategies depends on species of the microorganisms, forming the biofilm, and, accordingly, on the composition of the biopolymer matrix. For example, rhamnolipids and alginate of Pseudomonas aeruginosa exert a significant negative effect on the function of immunocompetent cells. The bacteria of biofilms became able to turn to their advantage many of the protective reactions developed by the immune system and fixed evolutionarily, applying them for the growth and development of the microbial consortium.

scholarly journals Ubiquitinated Hepatitis D Antigen-Loaded Microvesicles Induce a Potent Specific Cellular Immune Response to Inhibit HDV Replication in Vivo

2021 ◽  
Author(s):  
Ting Yao ◽  
Mengjiao Lv ◽  
Siyuan Ma ◽  
Jinmei Chen ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
Liver Cirrhosis ◽  
Viral Hepatitis ◽  
Cellular Immune Response ◽  
Hepatitis D ◽  
Specific Cellular Immune Response ◽  
D Antigen ◽  
Cellular Immune

Hepatitis D is the most severe viral hepatitis with accelerating the process of liver cirrhosis and increasing the risk of hepatocellular carcinoma. However, there are no effective antiviral drugs.

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