Rosin-based block copolymer intracellular delivery nanocarriers with reduction-responsive sheddable coronas for cancer therapy

Rosin-based, reduction-responsive block copolymer-based nanocarriers exhibiting excellent colloidal stability enabling the delivery of anticancer drugs to cancerous tissues for the enhanced release of encapsulated drugs, offering great versatility as intracellular drug-delivery nanocarriers for cancer therapy.

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Redox-Sensitive Polymer Micelles Based on CD44 and Folic Acid Receptor for Intracellular Drug Delivery and Drug Controlled Release in Cancer Therapy

ACS Applied Bio Materials ◽

10.1021/acsabm.9b00500 ◽

2019 ◽

Vol 2 (10) ◽

pp. 4222-4232

Author(s):

Beibei Lu ◽

Zhourui Xiao ◽

Zhenyuan Wang ◽

Binshen Wang ◽

Weiwei Zhao ◽

...

Keyword(s):

Drug Delivery ◽

Folic Acid ◽

Controlled Release ◽

Cancer Therapy ◽

Polymer Micelles ◽

Acid Receptor ◽

Drug Controlled Release ◽

Intracellular Drug Delivery ◽

Folic Acid Receptor

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Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles

Nanoscale ◽

10.1039/c5nr02730f ◽

2015 ◽

Vol 7 (34) ◽

pp. 14191-14216 ◽

Cited By ~ 93

Author(s):

Seonmi Baek ◽

Rajendra K. Singh ◽

Dipesh Khanal ◽

Kapil D. Patel ◽

Eun-Jung Lee ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Anticancer Drugs ◽

Anticancer Therapy ◽

Mesoporous Nanoparticles

Effectiveness of the delivery of anticancer drugs and the efficacy of cancer therapy can be enhanced using smart multifunctional mesoporous nanoparticles.

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Intracellular drug delivery: Potential usefulness of engineered Shiga toxin subunit B for targeted cancer therapy

Biotechnology Advances ◽

10.1016/j.biotechadv.2018.02.005 ◽

2018 ◽

Vol 36 (3) ◽

pp. 613-623 ◽

Cited By ~ 8

Author(s):

Vera Luginbuehl ◽

Nicolas Meier ◽

Karin Kovar ◽

Jack Rohrer

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Shiga Toxin ◽

Potential Usefulness ◽

Targeted Cancer Therapy ◽

Intracellular Drug Delivery ◽

Subunit B

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Tumor-targeting intracellular drug delivery based on dual acid/reduction-degradable nanoassemblies with ketal interface and disulfide core locations

Polymer Chemistry ◽

10.1039/c9py00352e ◽

2019 ◽

Vol 10 (22) ◽

pp. 2840-2853 ◽

Cited By ~ 8

Author(s):

Arman Moini Jazani ◽

Newsha Arezi ◽

Chaitra Shetty ◽

Sung Hwa Hong ◽

Haowen Li ◽

...

Keyword(s):

Drug Delivery ◽

Block Copolymer ◽

Drug Release ◽

Tumor Targeting ◽

Intracellular Drug Delivery ◽

Acid Reduction

Dual acid/reduction-degradable block copolymer nanoassemblies both at core/corona interfaces and in micellar cores leading to synergistic and accelerated drug release for robust tumor-targeting intracellular drug delivery.

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Shell-Detachable Micelles Based on Disulfide-Linked Block Copolymer As Potential Carrier for Intracellular Drug Delivery

Bioconjugate Chemistry ◽

10.1021/bc900144m ◽

2009 ◽

Vol 20 (6) ◽

pp. 1095-1099 ◽

Cited By ~ 212

Author(s):

Ling-Yan Tang ◽

Yu-Cai Wang ◽

Yang Li ◽

Jin-Zhi Du ◽

Jun Wang

Keyword(s):

Drug Delivery ◽

Block Copolymer ◽

Intracellular Drug Delivery

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PEG-SS-PPS: Reduction-Sensitive Disulfide Block Copolymer Vesicles for Intracellular Drug Delivery

Biomacromolecules ◽

10.1021/bm070085x ◽

2007 ◽

Vol 8 (6) ◽

pp. 1966-1972 ◽

Cited By ~ 311

Author(s):

Simona Cerritelli ◽

Diana Velluto ◽

Jeffrey A. Hubbell

Keyword(s):

Drug Delivery ◽

Block Copolymer ◽

Intracellular Drug Delivery

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Thermosensitive P(NIPAM-co-AM)-b-PLA block copolymer micelles for applications in intracellular drug delivery

Journal of Drug Delivery Science and Technology ◽

10.1016/s1773-2247(14)50022-6 ◽

2014 ◽

Vol 24 (2) ◽

pp. 136-142 ◽

Cited By ~ 3

Author(s):

Feng Xu ◽

Bi-Xia Zhang ◽

Yan-Ling Luo

Keyword(s):

Drug Delivery ◽

Block Copolymer ◽

Intracellular Drug Delivery ◽

Block Copolymer Micelles ◽

Copolymer Micelles

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Lipid Nanocapsules for Intracellular Drug Delivery of Anticancer Drugs

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2007.18114 ◽

2007 ◽

Vol 7 (12) ◽

pp. 4612-4617 ◽

Cited By ~ 33

Author(s):

Franck Lacoeuille ◽

Emmanuel Garcion ◽

Jean-Pierre Benoit ◽

Alf Lamprecht

Keyword(s):

Drug Delivery ◽

Cell Culture ◽

Drug Release ◽

Anticancer Drugs ◽

Cancer Cell ◽

Release Kinetics ◽

Laser Scanning Microscopy ◽

Lipid Nanocapsules ◽

Intracellular Drug Delivery ◽

Drug Concentrations

As non-phagocytic eukaryotic cells can internalize particles <1 μm in size, small size (25 to 110 nm) lipid nanocapsules (LNC) are proposed for the intracellular drug delivery of anticancer drugs to cancer cells. LNC ofdifferent diameters were loaded with etoposide or paclitaxel and subsequently tested for drug release kinetics and their efficiency to reduce cancer cell growth in cell culture. Relative high drug loads could be achieved and sustained drug release can be provided over a period ofseveral days (etoposide) up to a few weeks (paclitaxel). While particle size exhibited only minor influences on the release kinetics, higher initial drug load led to a distinctly lower burst release. In a cancer cell culture model, etoposide or paclitaxel LNC showed a 4-fold or 40-fold higher efficiency, respectively than the drug solution while blank LNC were found to be less toxic than the pure drug at equivalent concentrations. The uptake and intracellular accumulation ofLNC was confirmed by confocal laser scanning microscopy after fluorescence labeling of the nanocarriers. This nanoparticulate system is able to achieve efficient intracellular drug concentrations and seems to be therefore a promising therapeutic approach in cancer treatment.

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