Near-infrared light-sensitive liposomes for controlled release

RSC Advances ◽  
2016 ◽  
Vol 6 (84) ◽  
pp. 81245-81249 ◽  
Author(s):  
Yawei Sun ◽  
Yanyun Ji ◽  
Haiyan Yu ◽  
Dong Wang ◽  
Meiwen Cao ◽  
...  

A 6-bromo-7-hydroxy-4-hydroxymethylcoumarin containing amphiphilic lipid was synthesized and applied as a near-infrared light triggered controlled release system.

Nanoscale ◽  
2019 ◽  
Vol 11 (34) ◽  
pp. 15810-15820 ◽  
Author(s):  
Li Chengnan ◽  
Quentin Pagneux ◽  
Anna Voronova ◽  
Alexandre Barras ◽  
Amar Abderrahmani ◽  
...  

Drug loaded hydrogels have proven to be versatile controlled-release systems.


2009 ◽  
Vol 1241 ◽  
Author(s):  
Shuji Yamashita ◽  
Hiromitsu Fukushima ◽  
Yasuro Niidome ◽  
Takeshi Mori ◽  
Yoshiki Katayama ◽  
...  

AbstractGold nanorods, rod-shaped gold nanoparticles, have transverse and longitudinal surface plasmon (SP) bands at visible and near-infrared (IR) regions, respectively. Since the absorbed light energy is converted into heat, photothermal effect of gold nanorods can be triggered without damaging the tissues in the path of near-IR laser light. In this study, we tried to construct controlled release system of functional molecules from surface of gold nanorods mediated by the photothermal effect. First, we evaluated controlled release of poly(ethyleneglycol) (PEG) chains from PEG-modified gold nanorods (PEG-NR). Next, we employed double stranded oligonucleotide as a thermo-responsive dissociating group (DNA-NR). Finally, we evaluated photothermal release of PEG chains mediated retro-Diels-Alder reaction (PEG-DA-NR). For construction of controlled release system of functional molecules, these studies will provide important information about the photothermal reactions of surface molecules on the gold nanorods triggered by near-IR light irradiation.


2016 ◽  
Vol 1 (3) ◽  
pp. 357-364 ◽  
Author(s):  
Christian Wiraja ◽  
Malathi Mathiyazhakan ◽  
Fatemeh Movahedi ◽  
Paul Kumar Upputuri ◽  
Yingying Cheng ◽  
...  

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2392
Author(s):  
Xin Zhang ◽  
Mengmeng Zhang ◽  
Mingyue Wu ◽  
Linchuan Yang ◽  
Rui Liu ◽  
...  

Precise control of target molecule release time, site, and dosage remains a challenge in controlled release systems. We employed a photoresponsive molecule release system via light-triggered charge reversal nanoparticles to achieve a triggered, stepwise, and precise controlled release platform. This release system was based on photocleavage-bridged polysilsesquioxane nanoparticles which acted as nanocarriers of doxorubicin loaded on the surface via electrostatic interaction. The nanoparticles could reverse into positive charges triggered by 254 nm light irradiation due to the photocleavage of the o-nitrobenzyl bridged segment. The charge reversal property of the nanoparticles could release loaded molecules. Doxorubicin was selected as a positively charged model molecule. The as-prepared nanoparticles with an average size of 124 nm had an acceptable doxorubicin loading content up to 12.8%. The surface charge of the nanoparticles could rapidly reverse from negative (−28.20 mV) to positive (+18.9 mV) upon light irradiation for only 10 min. In vitro release experiments showed a cumulative release up to 96% with continuously enhancing irradiation intensity. By regulating irradiation parameters, precisely controlled drug release was carried out. The typical “stepped” profile could be accurately controlled in an on/off irradiation mode. This approach provides an ideal light-triggered molecule release system for location, timing, and dosage. This updated controlled release system, triggered by near-infrared or infrared light, will have greater potential applications in biomedical technology.


2018 ◽  
Vol 47 (9) ◽  
pp. 3185-3192 ◽  
Author(s):  
Ediana P. Rebitski ◽  
Pilar Aranda ◽  
Margarita Darder ◽  
Raffaele Carraro ◽  
Eduardo Ruiz-Hitzky

Metformin hydrochloride is spontaneously intercalated into layered silicates like montmorillonite by an ion-exchange mechanism, producing a promising controlled release system.


2019 ◽  
Vol 31 (11) ◽  
pp. 3948-3956 ◽  
Author(s):  
Fei Wang ◽  
Zhenwei Yuan ◽  
Patrick McMullen ◽  
Ruixi Li ◽  
Jinrong Zheng ◽  
...  

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