scholarly journals Organic molecule-based photothermal agents: an expanding photothermal therapy universe

2018 ◽  
Vol 47 (7) ◽  
pp. 2280-2297 ◽  
Author(s):  
Hyo Sung Jung ◽  
Peter Verwilst ◽  
Amit Sharma ◽  
Jinwoo Shin ◽  
Jonathan L. Sessler ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Organic Molecule ◽  
Inorganic Nanomaterials ◽  
Potential Complement

Over the last decade, organic photothermal therapy (PTT) agents have attracted increasing attention as a potential complement for, or alternative to, classical drugs and sensitizers involving inorganic nanomaterials.

Near-infrared Inorganic Nanomaterials-based Nanosystem for Photothermal Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Yufei Wang ◽  
Hongmin Meng ◽  
Zhaohui Li
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Strong Absorption ◽  
Non Invasive ◽  
Inorganic Nanomaterials

The development of robust materials for treating diseases through non-invasive photothermal therapy (PTT) has attracted increasing attention in recent years. Among many types of nanomaterials, inorganic nanomaterials with strong absorption...

scholarly journals Bioinspired carrier-free peptide conjugated BF2-oxasmaragdyrin dye-based nano self-assemblies: a photostable NIR cancer theragnostic agent

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Kandala Laxman ◽  
B. Pradeep K. Reddy ◽  
Sumit K. Mishra ◽  
Andrea Robinson ◽  
Abhijit De ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Visible Region ◽  
Whole Body ◽  
Water Mixture ◽  
Free Peptide ◽  
Nirf Imaging ◽  
Nir Fluorescence ◽  
Inorganic Nanomaterials

AbstractPhotothermal therapy (PTT) has attracted great interest in cancer treatment, and the quest for potential organic photothermal agents is underway owing to the nonbiodegradable nature and chronic toxicity of existing inorganic nanomaterials. Organic material-based nanoformulations with good photothermal and fluorescence properties in the near-infrared (NIR-I) window are scarce. However, porphyrins are one category of biocompatible systems that are advantageous for photothermal therapy but are currently based in the visible region, causing limited depth of tissue penetration and leading to compromised photothermal and near-infrared fluorescence (NIRF) imaging applications. To overcome these limitations, we report the synthesis of L,L-diphenylalanine conjugated BF2-oxasmaragdyrin (FF-BSC) and the fabrication of monodispersed spherical self-assemblies (FF-BSC NPs) using a USP class 3 solvent-water mixture. The resulting product exhibited excellent photostability (NIR exposure), multicycle photothermal efficacy, and NIR fluorescence. In vitro studies revealed good biocompatibility, efficient cellular internalization, and photothermal efficacy. Preclinical studies of these nano-self-assemblies demonstrated nontoxicity, efficient whole-body NIRF imaging, fractional passive tumor homing, and excellent photothermal tumor ablation potential. The absorbance and fluorescence of FF-BSC NPs in NIR-I make them suitable for theragnostic applications over existing porphyrins/inorganic nanomaterials for future clinical applications.

scholarly journals Near-infrared light-responsive inorganic nanomaterials for photothermal therapy

2016 ◽  
Vol 11 (3) ◽  
pp. 349-364 ◽  
Author(s):  
Zhihong Bao ◽  
Xuerong Liu ◽  
Yangdi Liu ◽  
Hongzhuo Liu ◽  
Kun Zhao
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Inorganic Nanomaterials

scholarly journals Inorganic nanomaterials for chemo/photothermal therapy: a promising horizon on effective cancer treatment

2019 ◽  
Vol 11 (3) ◽  
pp. 335-352 ◽  
Author(s):  
Mona Khafaji ◽  
Masoud Zamani ◽  
Mortaza Golizadeh ◽  
Omid Bavi
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Inorganic Nanomaterials

scholarly journals Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment

2020 ◽  
Vol Volume 15 ◽  
pp. 1903-1914 ◽  
Author(s):  
Ji Wang ◽  
Xia Wu ◽  
Peng Shen ◽  
Jun Wang ◽  
Yidan Shen ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Inorganic Nanomaterials

"All-in-One" Strategy Based on Organic Molecule DCN-4CQA for Effective NIR Fluorescence Imaging guided Dual Phototherapy

2021 ◽  
Author(s):  
Tianlei Zhou ◽  
Tao Jia ◽  
Lu Li ◽  
Yanjie Liu ◽  
Tiedong Sun ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Organic Molecule ◽  
Single Treatment ◽  
Therapeutic Method ◽  
Nir Fluorescence ◽  
Single Material

Combined with dual phototherapy, photodynamic therapy (PDT) and photothermal therapy (PTT), is considered as the more effective therapeutic method of cancer than single treatment. Therefore, development of single material with...

Overview of the application of inorganic nanomaterials in cancer photothermal therapy

2020 ◽  
Vol 8 (11) ◽  
pp. 2990-3020 ◽  
Author(s):  
Natanael Fernandes ◽  
Carolina F. Rodrigues ◽  
André F. Moreira ◽  
Ilídio J. Correia
Keyword(s):  
Therapeutic Effect ◽  
Photothermal Therapy ◽  
Inorganic Nanomaterials

Cancer photothermal therapy (PTT) has captured the attention of researchers worldwide due to its localized and trigger-activated therapeutic effect.

High Resolution Replication of Organoclay Surfaces

1982 ◽  
Vol 40 ◽  
pp. 576-577
Author(s):  
W. W. Barker ◽  
W. E. Rigsby ◽  
V. J. Hurst ◽  
W. J. Humphreys
Keyword(s):  
Clay Mineral ◽  
Organic Molecule ◽  
Organic Molecules ◽  
X Ray Diffraction ◽  
Xrd Pattern ◽  
X Ray ◽  
Naturally Occurring ◽  
Silicate Layers ◽  
Mineral Identification

Experimental clay mineral-organic molecule complexes long have been known and some of them have been extensively studied by X-ray diffraction methods. The organic molecules are adsorbed onto the surfaces of the clay minerals, or intercalated between the silicate layers. Natural organo-clays also are widely recognized but generally have not been well characterized. Widely used techniques for clay mineral identification involve treatment of the sample with H2 O2 or other oxidant to destroy any associated organics. This generally simplifies and intensifies the XRD pattern of the clay residue, but helps little with the characterization of the original organoclay. Adequate techniques for the direct observation of synthetic and naturally occurring organoclays are yet to be developed.

NIR-active Nanoterminator with Mature Dendritic Cell Acitivities for Immuno-Priming Mild Photothermal Cancer Therapy

2020 ◽  
Author(s):  
zhihong sun ◽  
Guanjun Deng ◽  
Xinghua Peng ◽  
Xiuli Xu ◽  
Lanlan Liu ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Photothermal Therapy ◽  
Whole Body ◽  
Mature Dendritic Cell ◽  
Immune Microenvironment ◽  
Highly Efficient ◽  
Tumor Immune Microenvironment ◽  
Shock Proteins ◽  
Mild Temperature ◽  
Broad Interest

Recently, photothermal-immuno synergistic therapy under mild temperature (~ 45 °C) has got broad interest in cancer treatment. Inhibition the intratumorally HSPs production is the key to accomplish highly efficient and mild photothermal therapy. In this work, we developed biomimetic nanoterminators with mature DCs functions by coating the mature dendritic cell membrane on photothermal nanoagents. As-prepared nanoterminators could automatically locate on T cell in the complex tumor-immune microenvironment and promote the T cells proliferation, activation and cytokine secretion, which could not only inhibit the expression of heat shock proteins to cooperate on highly efficient mild photothermal therapy (~42°C), but also promote tumor apoptosis during the treatment. More importantly, this nanoterminator could serve as vaccine to trigger anti-tumor immune response of the whole body, which would be promising to long-life tumor inhibition and termination.

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