scholarly journals Interaction of indomethacin with calf thymus DNA: a multi-spectroscopic, thermodynamic and molecular modelling approach

MedChemComm ◽  
2017 ◽  
Vol 8 (6) ◽  
pp. 1283-1296 ◽  
Author(s):  
Mohammed Amir Husain ◽  
Hassan Mubarak Ishqi ◽  
Tarique Sarwar ◽  
Sayeed Ur Rehman ◽  
Mohammad Tabish
Keyword(s):  
Acetic Acid ◽  
Acid Derivative ◽  
Molecular Modelling ◽  
Biological Activities ◽  
Calf Thymus Dna ◽  
Calf Thymus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Modelling Approach

Indomethacin belongs to the acetic acid derivative class of non-steroidal anti-inflammatory drugs with diverse pharmacological and biological activities.

scholarly journals INTERACTION OF TWO FLAVONOIDS WITH CALF THYMUS DNA: A MULTI - SPECTROSCOPIC, ELECTROCHEMICAL AND MOLECULAR MODELLING APPROACH

2018 ◽  
Vol 7 (1) ◽  
pp. 10 ◽  
Author(s):  
Venmathy Prabhakaran ◽  
J. Jeyasundari ◽  
V. S. Vasantha ◽  
P. Nandha Kumar ◽  
M. Sakthi
Keyword(s):  
Molecular Modelling ◽  
Calf Thymus Dna ◽  
Calf Thymus ◽  
Modelling Approach

Elucidating the interaction of sulindac with calf thymus DNA: biophysical and in silico molecular modelling approach

2017 ◽  
Vol 41 (24) ◽  
pp. 14924-14935 ◽  
Author(s):  
Mohammed Amir Husain ◽  
Hassan Mubarak Ishqi ◽  
Sayeed Ur Rehman ◽  
Tarique Sarwar ◽  
Shumaila Afrin ◽  
...  
Keyword(s):  
Molecular Modelling ◽  
In Silico ◽  
Calf Thymus Dna ◽  
Calf Thymus ◽  
Modelling Approach

Sulindac is one of the most effective NSAIDs and belongs to the arylalkanoic acid class.

scholarly journals Exacerbation of acetic acid ulcer induced by non-steroidal anti-inflammatory drugs in rats.

1983 ◽  
Vol 33 (2) ◽  
pp. 447-454 ◽  
Author(s):  
Hiroshi TANAKA ◽  
Katsuichi SHUTO ◽  
Nobuhiro NAKAMIZO
Keyword(s):  
Acetic Acid ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals PYRIMIDINES AS POTENT CYTOTOXIC AND ANTI-INFLAMMATORY AGENTS

2017 ◽  
Vol 10 (6) ◽  
pp. 237 ◽  
Author(s):  
Ishwar Bhat K ◽  
Abhishek Kumar
Keyword(s):  
Acetic Acid ◽  
Cytotoxic Activity ◽  
Glacial Acetic Acid ◽  
Antimalarial Activity ◽  
Biological Activities ◽  
Cytotoxic Agents ◽  
Pyrimidine Derivatives ◽  
Pharmacological Activities ◽  
Anti Inflammatory ◽  
Derivatives Of

Objective: Many derivatives of pyrimidine are known for the broad-spectrum biological activities such as antimicrobial, antitumor, antibacterial, antitubercular, anti-inflammatory, and cytotoxic activity. Chalcones with an enone group show potent pharmacological activities such as antiinflammatory, antibacterial, antifungal, and antimalarial activity. A series of pyrimidines from chalcones have been synthesized and screened for anti-inflammatory and cytotoxic activity studies.Methods: Chalcones [1-(4-nitrophenyl)-3-substituted-phenylprop-2-en-1-one] were synthesized from various substituted aldehydes with 4-nitroacetophenone and cyclized with urea and glacial acetic acid to give pyrimidine derivatives [4-(4-nitrophenyl)-6-substituted-phenylpyrimidin-2-ol].Results: Anti-inflammatory and cytotoxic activity studies revealed that some of the synthesized compounds have shown significant activity.Conclusion: The observed results proved that pyrimidines are found to be interesting lead molecules for the synthesis of anti-inflammatory and cytotoxic agents

scholarly journals Evaluation of Analgesic and Anti-inflammatory Activities of Polyalthia simiarum (Hook. F. &Thomson)

2019 ◽  
Vol 5 (1) ◽  
pp. 18-23
Author(s):  
Selina Kabir ◽  
Ronok Zahan ◽  
Abdullah Mohammad Sarwaruddin Chowdhury ◽  
Choudhury Mahmood Hasan ◽  
Mohammad Abdur Rashid
Keyword(s):  
Acetic Acid ◽  
Analgesic Activity ◽  
Biological Activities ◽  
Dependent Manner ◽  
Paw Edema ◽  
Immersion Method ◽  
Ongoing Research ◽  
Tail Immersion ◽  
Anti Inflammatory ◽  
Dose Dependent

Background: Polyalthia simiarum (Hook. F. &Thomson) exhibits different effects in human body. Objective: As a part of ongoing research on medicinal plants of Bangladesh, the present study is focused to investigate the analgesic and anti-inflammatory activities of stem bark of Polyalthia simiarum (Annonaceae). Methodology: The ethyl acetate (EA) and petroleum ether (PE) extracts were subjected to qualitative chemical investigation for the identification of different phytoconstituents. The analgesic activity was determined for its central and peripheral pharmacological actions using tail immersion method and acetic acid-induced writhing test. The anti-inflammatory activity was evaluated by carrageenan induced paw edema in rats. Analgesic and anti-inflammatory data were evaluated statistically analysed by Dunnett’s-T test. Result: Both extracts at the dose of 50- and 100 mg/kg b.w., produced significant increase in pain threshold in tail immersion method whereas significantly reduced the writhing caused by acetic acid in a dose dependent manner. The EA and PE extracts showed anti-inflammatory activities at 50- and 100 mg/kg body weight. Among all the extracts, the EA extract showed a dose dependent and comparable analgesic activity in all the tested methods and also reduced the paw edema considerably (27.5% and 39.1% inhibition after 4h), in dose dependent manner when compared to carrageenan induced control rat. Conclusion: Therefore, the EA and PE extracts of Polyalthia simiarum were capable to exhibit moderate analgesic and anti-inflammatory activities. This is the first report of analgesic and anti-inflammatory potential of Polyalthia simiarum and can be further investigated to isolate the active compounds responsible for the biological activities. Journal of National Institute of Neurosciences Bangladesh, 2019;5(1): 18-23

scholarly journals EXACERBATION OF ACETIC ACID ULCER INDUCED BY NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IN RATS

1983 ◽  
Vol 33 (2) ◽  
pp. 447-454
Author(s):  
Hiroshi TANAKA ◽  
Katsuichi SHUTO ◽  
Nobuhiro NAKAMIZO
Keyword(s):  
Acetic Acid ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Caffeic acid binds to the minor groove of calf thymus DNA: A multi-spectroscopic, thermodynamics and molecular modelling study

2017 ◽  
Vol 98 ◽  
pp. 319-328 ◽  
Author(s):  
Tarique Sarwar ◽  
Hassan Mubarak Ishqi ◽  
Sayeed Ur Rehman ◽  
Mohammed Amir Husain ◽  
Yusra Rahman ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Molecular Modelling ◽  
Minor Groove ◽  
Calf Thymus Dna ◽  
Calf Thymus ◽  
Modelling Study
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