scholarly journals Near infrared laser-controlled drug release of thermoresponsive microgel encapsulated with Fe3O4 nanoparticles

RSC Advances ◽  
2017 ◽  
Vol 7 (32) ◽  
pp. 19604-19610 ◽  
Author(s):  
Xiaofang Qi ◽  
Lu Xiong ◽  
Jing Peng ◽  
Dongyan Tang
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Drug Release ◽  
Fe3o4 Nanoparticles ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
External Stimuli

One major issue in thermosensitive drug delivery systems is the remote, repeatable control of temperature in vivo through external stimuli such as light, ultrasound, and magnetic field.

Nanostructured Ketorolac-Tromethamine/MCF: Synthesis, Characterization and Application in Drug Release System

2018 ◽  
Vol 14 (5) ◽  
pp. 432-439 ◽  
Author(s):  
Juliana M. Juarez ◽  
Jorgelina Cussa ◽  
Marcos B. Gomez Costa ◽  
Oscar A. Anunziata
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Therapeutic Efficacy ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
The Body ◽  
Fickian Diffusion ◽  
Ketorolac Tromethamine

Background: Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured Cellular Foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Methods: Ketorolac-Tromethamine/MCF composite was synthesized. The material synthesis and loading of ketorolac-tromethamine into MCF pores were successful as shown by XRD, FTIR, TGA, TEM and textural analyses. Results: We obtained promising results for controlled drug release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times. This allows keeping drug concentration within the range of therapeutic efficacy, being highly applicable for the treatment of diseases that need a rapid response. The release of KETO/MCF was compared with other containers of KETO (KETO/SBA-15) and commercial tablets. Conclusion: The best model to fit experimental data was Ritger-Peppas equation. Other models used in this work could not properly explain the controlled drug release of this material. The predominant release of KETO from MCF was non-Fickian diffusion.

Formulation, Development and Characterization of Floating Beads of Diltiazem Hydrochloride

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Anamika Saxena Saxena ◽  
Santosh Kitawat ◽  
Kalpesh Gaur ◽  
Virendra Singh
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Entrapment Efficiency ◽  
Repeated Administration ◽  
Alginate Beads ◽  
Delivery Systems ◽  
Sem Analysis ◽  
Formulation Development

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and nontoxic for a prolonged period. Various attempts have been made to develop gastroretentive delivery systems such as high density system, swelling, floating system. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. Gastric emptying is a complex process and makes in vivo performance of the drug delivery systems uncertain. In order to avoid this variability, efforts have been made to increase the retention time of the drug-delivery systems for more than 12 hours. The floating or hydrodynamically controlled drug delivery systems are useful in such application. Background of the research: Diltiazem HCL (DTZ), has short biological half life of 3-4 h, requires rather high frequency of administration. Due to repeated administration there may be chances of patient incompliance and toxicity problems. Objective: The objective of study was to develop sustained release alginate beads of DTZ for reduction in dosing frequency, high bioavailability and better patient compliance. Methodology: Five formulations prepared by using different drug to polymer ratios, were evaluated for relevant parameters and compared. Alginate beads were prepared by ionotropic external gelation technique using CaCl2 as cross linking agent. Prepared beads were evaluated for % yield, entrapment efficiency, swelling index in 0.1N HCL, drug release study and SEM analysis. In order to improve %EE and drug release, LMP and sunflower oil were used as copolymers along with sodium alginate.

Nanocarriers with multi-locked DNA valves targeting intracellular tumor-related mRNAs for controlled drug release

Nanoscale ◽  
2017 ◽  
Vol 9 (44) ◽  
pp. 17318-17324 ◽  
Author(s):  
Yanhua Li ◽  
Yuanyuan Chen ◽  
Wei Pan ◽  
Zhengze Yu ◽  
Limin Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Cells ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Normal Cells ◽  
Tremendous Challenge

The fabrication of well-behaved drug delivery systems that can transport drugs to specifically treat cancer cells rather than normal cells is still a tremendous challenge.

scholarly journals Stimuli-Responsive Nanofibers Containing Gold Nanorods for On-Demand Drug Delivery Platforms

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1319
Author(s):  
Baljinder Singh ◽  
Nutan Shukla ◽  
Junkee Kim ◽  
Kibeom Kim ◽  
Myoung-Hwan Park
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Gold Nanorods ◽  
Drug Delivery Systems ◽  
Near Infrared ◽  
Resonance Effect ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
On Demand ◽  
Multiple Drugs

On-demand drug delivery systems using nanofibers have attracted significant attention owing to their controllable properties for drug release through external stimuli. Near-infrared (NIR)-responsive nanofibers provide a platform where the drug release profile can be achieved by the on-demand supply of drugs at a desired dose for cancer therapy. Nanomaterials such as gold nanorods (GNRs) exhibit absorbance in the NIR range, and in response to NIR irradiation, they generate heat as a result of a plasmon resonance effect. In this study, we designed poly (N-isopropylacrylamide) (PNIPAM) composite nanofibers containing GNRs. PNIPAM is a heat-reactive polymer that provides a swelling and deswelling property to the nanofibers. Electrospun nanofibers have a large surface-area-to-volume ratio, which is used to effectively deliver large quantities of drugs. In this platform, both hydrophilic and hydrophobic drugs can be introduced and manipulated. On-demand drug delivery systems were obtained through stimuli-responsive nanofibers containing GNRs and PNIPAM. Upon NIR irradiation, the heat generated by the GNRs ensures shrinking of the nanofibers owing to the thermal response of PNIPAM, thereby resulting in a controlled drug release. The versatility of the light-responsive nanofibers as a drug delivery platform was confirmed in cell studies, indicating the advantages of the swelling and deswelling property of the nanofibers and on–off drug release behavior with good biocompatibility. In addition, the system has potential for the combination of chemotherapy with multiple drugs to enhance the effectiveness of complex cancer treatments.

Thermally Activated Noble Metal Nanoparticles Incorporated in Electrospun Fiber-based Drug Delivery Systems

2019 ◽  
Vol 4 (1) ◽  
pp. 21-31 ◽  
Author(s):  
Enza Fazio ◽  
Alessandro Ridolfo ◽  
Giulia Neri
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Drug Release ◽  
Noble Metal ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Photothermal Effect ◽  
Release Mechanism ◽  
Time Interval ◽  
Visible Radiation

Background: Nanosystems based on PEG-PLGA copolymer have attracted increasing interest in several biomedicine fields, due to their unique properties. Commonly, PEG-PLGA copolymer was used to formulate nanoparticles (NPs) for drug delivery applications. Only recently, the engineering of polymeric nanofibrous membrane able to be use like drug nanocarrier was investigated. Objective: The goal of this work is the development of two new drug delivery systems based on PEGylated-PLGA nanofibrous scaffolds, obtained by electrospinning deposition, simultaneous loaded with: i) silibinin, a therapeutic agent, ii) Au/Ag and iii) non-toxic Fe2O3 magnetic nanoparticles. Another interest aspect of the present work regards how the morphological structure can influence the drug release which has been fine-tuned by two external stimuli: a light source and a magnetic field. Methods: Noble metal nanocolloids were prepared in water by the pulsed laser ablation technique. The PEG-PLGA@Au/Ag-SLB added with Fe2O3-PVA nanofibers were fabricated by the electrospinning deposition method. Results: The use of “Surface Plasmon Resonance”-mediated localized photothermal effect, determined by the nanoparticles resonant absorption of visible radiation, allows to these systems to be able to employ for photothermal drug delivery therapies in proximity of tumor cells. All data obtained about the fiber scaffolds are compared to NPs based on the same PEG-PLGA copolymer, loaded with silibinin, Fe2O3 and Au/Ag nanoparticles alternatively. Nanofibers respects to NPs, showed interesting sustained responsive silibinin release for at least 60 h, without the burst effect. A diffusion-based theoretical model approach allowed to precisely describe the release mechanism. Conclusion: The effective and controlled silibilin drug release, upon application of either light irradiation or magnetic field for a definite time interval, has been demonstrated. Under the light stimulus, the fiber-shaped nanosystem reached a cumulative drug release value as high as 70% in the long time. On the overall, the information obtained could be useful to design suitable “on demand” nanocomposites in view of a therapeutic treatments protocol that requires a fast pharmacological action.

scholarly journals Development and Evaluation of Novel Self-Nanoemulsifying Drug Delivery Systems Based on a Homolipid from Capra hircus and Its Admixtures with Melon Oil for the Delivery of Indomethacin

2014 ◽  
Vol 2014 ◽  
pp. 1-9
Author(s):  
Nicholas C. Obitte ◽  
Kenneth C. Ofokansi ◽  
Franklin C. Kenechukwu
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Tween 80 ◽  
Delivery Systems ◽  
Inflammatory Activity ◽  
Capra Hircus ◽  
Anti Inflammatory

In this study, goat fat (Capra hircus) and melon oil were extracted and used to formulate self-nanoemulsifying drug delivery systems (SNEDDS) based on either goat fat alone or its admixture with melon oil by employing escalating ratios of oil(s), surfactant blend (1 : 1 Tween 60 and Tween 80), and cosurfactant (Span 85), with or without carbosil, a glidant, for the delivery of indomethacin. The formulations were encapsulated in hard gelatin capsules and then assessed using isotropicity test, aqueous dilution stability and precipitation propensity, absolute drug content, emulsification time, in vitro drug release, and anti-inflammatory activity. The SNEDDS exhibited low precipitation propensity and excellent stability on copious dilution, as well as high drug release in vitro and in vivo. The inhibition produced by the SNEDDS was comparable to that of indomethacin injection (positive control) for much of the 5 h test period, indicating a high degree of bioavailability of the administered SNEDDS. The absolute drug contents and emulsification times fell within narrow limits. This study has shown that a 1 : 1 ratio of melon oil and goat fat could confer favourable properties with respect to drug release and anti-inflammatory activity on SNEDDS for the delivery of indomethacin, thus encouraging further development of the formulations.

scholarly journals Carrier-free nanoparticles of camptothecin prodrug for chemo-photothermal therapy: the making, in vitro and in vivo testing

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Mingtao Ao ◽  
Fei Yu ◽  
Yixiang Li ◽  
Mengya Zhong ◽  
Yonghe Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Photothermal Therapy ◽  
Drug Delivery Systems ◽  
Therapeutic Agent ◽  
Delivery Systems ◽  
Amphiphilic Drug ◽  
Carrier Free

Abstract Background Nanoscale drug delivery systems have emerged as broadly applicable approach for chemo-photothermal therapy. However, these nanoscale drug delivery systems suffer from carrier-induced toxicity, uncontrolled drug release and low drug carrying capacity issues. Thus, to develop carrier-free nanoparticles self-assembled from amphiphilic drug molecules, containing photothermal agent and anticancer drug, are very attractive. Results In this study, we conjugated camptothecin (CPT) with a photothermal agent new indocyanine green (IR820) via a redox-responsive disulfide linker. The resulting amphiphilic drug–drug conjugate (IR820-SS-CPT) can self-assemble into nanoparticles (IR820-SS-CPT NPs) in aqueous solution, thus remarkably improving the membrane permeability of IR820 and the aqueous solubility of CPT. The disulfide bond in the IR820-SS-CPT NPs could be cleaved in GSH rich tumor microenvironment, leading to the on demand release of the conjugated drug. Importantly, the IR820-SS-CPT NPs displayed an extremely high therapeutic agent loading efficiency (approaching 100%). Besides, in vitro experimental results indicated that IR820-SS-CPT NPs displayed remarkable tumor cell killing efficiency. Especially, the IR820-SS-CPT NPs exhibited excellent anti-tumor effects in vivo. Both in vitro and in vivo experiments were conducted, which have indicated that the design of IR820-SS-CPT NPs can provide an efficient nanotherapeutics for chemo-photothermal therapy. Conclusion A novel activatable amphiphilic small molecular prodrug IR820-SS-CPT has been developed in this study, which integrated multiple advantages of GSH-triggered drug release, high therapeutic agent content, and combined chemo-photothermal therapy into one drug delivery system. Graphical Abstract

scholarly journals Metronidazole- and Amoxicillin-Loaded PLGA and PCL Nanofibers as Potential Drug Delivery Systems for the Treatment of Periodontitis: In Vitro and In Vivo Evaluations

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 975
Author(s):  
Shahla Mirzaeei ◽  
Mahla Mansurian ◽  
Kofi Asare-Addo ◽  
Ali Nokhodchi
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
High Performance ◽  
Drug Delivery Systems ◽  
Periodontal Diseases ◽  
Delivery Systems ◽  
Electrospinning Process ◽  
In Vitro Drug Release

The purpose of this study was to prepare poly (D-L) lactide-co-glycolide (PLGA) and poly ε-caprolactone (PCL) nanofibers containing metronidazole and amoxicillin using an electrospinning process as intrapocket sustained-release drug delivery systems for the treatment of periodontal diseases. Scanning electron microscopy showed that the drug containing PLGA and PCL nanofibers produced from the electrospinning process was uniform and bead-free in morphology. The obtained nanofibers had a strong structure and resisted external tension according to the tensiometry results. The cytotoxicity results indicated acceptable cell viability (>80%). Quantification by high-performance liquid chromatography showed almost complete in vitro drug release between 7 and 9 days, whereas 14 days were required for complete drug release in vivo. No significant signs of irritation or inflammatory reaction were detected after three weeks of subcutaneous implantation of nanofibers in the animal models, thus indicating suitable compatibility. The results therefore suggest that the designed nanofibers can be used as potential commercial formulations in the treatment of periodontitis as controlled-release intrapocket drug delivery systems that can increase patient compliance. This is due to their ability to reduce the frequency of administration from three times daily in a systemic manner to once weekly as local delivery.

Sign in / Sign up

Export Citation Format

Share Document