Enantioseparation using carboxymethyl-6-(4-methoxybenzylamino)-β-cyclodextrin as a chiral selector by capillary electrophoresis and molecular modeling study of the recognition mechanism

2020 ◽  
Vol 44 (3) ◽  
pp. 958-972 ◽  
Author(s):  
Yu Zhao ◽  
Jinlong Wang ◽  
Yanru Liu ◽  
Zhen Jiang ◽  
Yongbo Song ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Molecular Modeling ◽  
Chiral Selector ◽  
Chiral Drugs ◽  
Recognition Mechanism ◽  
Molecular Modeling Study ◽  
First Time ◽  
Modeling Study

In this study, carboxymethyl-6-(4-methoxybenzylamino)-β-cyclodextrin (CMCDPN) was synthesized for the first time and managed to be used as a chiral selector to enantioseparate 13 kinds of chiral drugs by capillary electrophoresis.

Molecular modeling study of the recognition mechanism and enantioseparation of 4-hydroxypropranolol by capillary electrophoresis using carboxymethyl-β-cyclodextrin as the chiral selector

The Analyst ◽  
2014 ◽  
Vol 139 (16) ◽  
pp. 3901-3910 ◽  
Author(s):  
Clebio Soares Nascimento ◽  
Juliana Fedoce Lopes ◽  
Luciana Guimarães ◽  
Keyller Bastos Borges
Keyword(s):  
Capillary Electrophoresis ◽  
Molecular Modeling ◽  
Chiral Selector ◽  
Elution Order ◽  
Recognition Mechanism ◽  
Theoretical Methods ◽  
Molecular Modeling Study ◽  
Modeling Study

Elution order elucidation of 4-hydroxypropranolol by capillary electrophoresis and theoretical methods.

Synthesis, application and molecular modeling study of ionic liquid functionalized lactobionic acid, 3-methyl-1-(3-sulfopropyl)-1H-imidazol-3-ium lactobionate, as a chiral selector in capillary electrophoresis

The Analyst ◽  
2020 ◽  
Vol 145 (3) ◽  
pp. 1025-1032 ◽  
Author(s):  
Hui Xu ◽  
Zijie Feng ◽  
Yingxiang Du
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Molecular Modeling ◽  
Chiral Selector ◽  
Lactobionic Acid ◽  
Molecular Modeling Study ◽  
Modeling Study

Ionic liquid MSI-LA was used as the sole chiral selector, both cation and anion contribute in forming interactions with enantiomers.

scholarly journals Chiral separation of rasagiline using sulfobutylether-β-cyclodextrin: capillary electrophoresis, NMR and molecular modeling study

2019 ◽  
Vol 40 (15) ◽  
pp. 1897-1903 ◽  
Author(s):  
Zoltán-István Szabó ◽  
Róbert Ludmerczki ◽  
Béla Fiser ◽  
Béla Noszál ◽  
Gergő Tóth
Keyword(s):  
Capillary Electrophoresis ◽  
Molecular Modeling ◽  
Chiral Separation ◽  
Molecular Modeling Study ◽  
Modeling Study

L-Histidinium Chiral Ionic Liquid Functionalized β-Cyclodextrin as Chiral Selector in Capillary Electrophoresis

2021 ◽  
Author(s):  
Xiaofei Ma ◽  
Jingtang Li ◽  
Xiaoqi Li ◽  
Zijie Feng ◽  
Xuan Yang ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Capillary Electrophoresis ◽  
Ionic Liquids ◽  
Molecular Modeling ◽  
Chiral Separation ◽  
Chiral Selector ◽  
Chiral Discrimination ◽  
Chiral Ionic Liquid ◽  
First Time ◽  
Good Agreement

Abstract Nowadays, ionic liquids (ILs) functionalized cyclodextrins (CDs) have drawn increasing attention in chiral separation. Herein, a novel β-CD derivative functionalized by L-histidinium IL, mono-6-deoxy-6-L-histidinium-β-cyclodextrin chloride (L-HMCDCl), was synthesized for the first time and utilized for enantioseparation of nefopam and chlorphenamine in capillary electrophoresis. The L-HMCDCl exhibited superior enantioselectivity compared with native β-CD. The effect of some key parameters such as chiral selector concentration, buffer pH and applied voltage on the enantioseparation was investigated in detail. In the interest of the chiral discrimination mechanism and the enhanced enantioselectivity of L-HMCDCl, molecular modeling with AutoDock was employed to study the interaction, which was in good agreement with experimental results.

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