Development of GLUT1-targeting alkyl glucoside-modified dihydroartemisinin liposomes for cancer therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (42) ◽  
pp. 21901-21912
Author(s):  
Shuo Shen ◽  
Maobo Du ◽  
Qingbo Liu ◽  
Peng Gao ◽  
Jigang Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting ◽  
Alkyl Glucoside

With the affinity of GLUT1 and an alkyl glucoside, the tumor targeting and anti-tumor effects of dihydroartemisinin liposomes are significantly improved.

A Low Dose of Hydrous Icaritin Nano-Formulation with Remarkable Efficacy and Tumor Targeting in Cancer Therapy

2021 ◽  
Vol 17 (10) ◽  
pp. 2003-2013
Author(s):  
Jingxin Fu ◽  
Yian Wang ◽  
Haowen Li ◽  
Likang Lu ◽  
Hui Ao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting ◽  
Low Dose ◽  
Drug Loading ◽  
Tumor Therapy ◽  
High Dose ◽  
Inhibition Rate ◽  
Tumor Inhibition ◽  
Nano Formulation ◽  
Tumor Inhibition Rate

Background: The use of chemotherapeutic drugs is restricted in the tumor-therapy because of the severely toxic and side effects among most important factors. The active herbal extracts are always used as a high dose while in the tumortherapy to achieve good anti-tumor effects. Hydrous icaritin has a high activity while there are few existing dosage forms as a result of low solubility in water and poor bioavailability. Results: The prepared hydrous icaritin nanorods (DP-HICT NRs) using mPEG2000-DSPE as a stabilizer, presented a narrow distribution of particle size with of 217 nm and a properly high drug-loading content of approximately 65.3±1.5%. A low dose of hydrous icaritin nano-formulation shows remarkable efficacy in cancer therapy (tumor inhibition rate: 61.36±10.80%) compared with the same dose of Paclitaxel injection (tumor inhibition rate: 66.80±4.43%), which approved as medicaments. Not only that, DP-HICT NRs can escape the clearance of the immune system and enhance targeting ability to the tumor site with only one excipient and such a low dose. Conclusions: This kind of nanoparticles contain a low dose of HICT used mPEG2000-DSPE as a stabilizer, while can achieve good tumor targeting as some active targeting agents and an anti-tumor effect as the PTX injection. There are broad prospects in drug safety, anti-tumor efficacy and even prognosis.

Host-cell-assisted construction of folate-engineered nanocarrier based on viral light particle for targeted cancer therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Cheng Lv ◽  
Jian Ao ◽  
Ji Wang ◽  
Man Tang ◽  
An-An Liu ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Host Cell ◽  
Tumor Targeting ◽  
Light Particle ◽  
Targeted Cancer Therapy ◽  
Normal Cells ◽  
Specific Tumor

Targeted cancer therapy has aroused broad interests of researchers due to its accuracy in specific tumor targeting and few side effects on normal cells. In the last decades, oncolytic viral...

Oxygen-enriched Fe3O4/Gd2O3 nanopeanuts for tumor-targeting MRI and ROS-triggered dual-modal cancer therapy through platinum (IV) prodrugs delivery

2020 ◽  
Vol 388 ◽  
pp. 124269 ◽  
Author(s):  
Guilong Zhang ◽  
Li Zhang ◽  
Yuanchun Si ◽  
Qingdong Li ◽  
Jianmin Xiao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting

scholarly journals Tumor-Targeting, MicroRNA-Silencing Porous Silicon Nanoparticles for Ovarian Cancer Therapy

2019 ◽  
Vol 11 (27) ◽  
pp. 23926-23937 ◽  
Author(s):  
Alessandro Bertucci ◽  
Kang-Hoon Kim ◽  
Jinyoung Kang ◽  
Jonathan M. Zuidema ◽  
Seo Hyeon Lee ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Porous Silicon ◽  
Cancer Therapy ◽  
Tumor Targeting ◽  
Silicon Nanoparticles ◽  
Porous Silicon Nanoparticles

scholarly journals Development of Tumor-Targeting IRE-1 Inhibitors for B-cell Cancer Therapy

2020 ◽  
Vol 19 (12) ◽  
pp. 2432-2444
Author(s):  
Andong Shao ◽  
Qin Xu ◽  
Walker T. Spalek ◽  
Christopher F. Cain ◽  
Chang Won Kang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
B Cell ◽  
Tumor Targeting ◽  
Cell Cancer

scholarly journals Novel functionalized nanoparticles for tumor-targeting co-delivery of doxorubicin and siRNA to enhance cancer therapy

2017 ◽  
Vol Volume 13 ◽  
pp. 143-159 ◽  
Author(s):  
Yu Xia ◽  
Tiantian Xu ◽  
Changbing Wang ◽  
Yinghua Li ◽  
Zhengfang Lin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting ◽  
Functionalized Nanoparticles

scholarly journals Nanoparticles Modified With Tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy

2010 ◽  
Vol 18 (9) ◽  
pp. 1650-1656 ◽  
Author(s):  
Yunching Chen ◽  
Xiaodong Zhu ◽  
Xiaoju Zhang ◽  
Bin Liu ◽  
Leaf Huang
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting

scholarly journals Tumor-targeting prodrug-activating bacteria for cancer therapy

2008 ◽  
Vol 15 (6) ◽  
pp. 393-401 ◽  
Author(s):  
C-M Cheng ◽  
Y-L Lu ◽  
K-H Chuang ◽  
W-C Hung ◽  
J Shiea ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting
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