scholarly journals Chicory inulin enhances fermentation of 2’-fucosyllactose by infant fecal microbiota and differentially influences immature dendritic cell and T-cell cytokine responses under normal and Th2-polarizing conditions

2021 ◽  
Author(s):  
Renate Akkerman ◽  
Madelon Joy Logtenberg ◽  
Martin Beukema ◽  
Bart J de Haan ◽  
Marijke M Faas ◽  
...  

Scope: Non-digestible carbohydrates (NDCs) such as native chicory inulin and 2’-fucosyllactose (2’-FL) are added to infant formula to mimic some of the human milk oligosaccharide (HMO) functions. It is unknown...

2019 ◽  
Vol 98 ◽  
pp. 38-43 ◽  
Author(s):  
Xiao Mao ◽  
Jianwu Wang ◽  
Yuanxin Hang ◽  
Yanchun Zhang ◽  
Huanhuan Yu ◽  
...  

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 790 ◽  
Author(s):  
Ana Lorena Ferreira ◽  
Ronaldo Alves ◽  
Amanda Figueiredo ◽  
Nadya Alves-Santos ◽  
Nathalia Freitas-Costa ◽  
...  

Human milk oligosaccharide (HMO) composition varies throughout lactation and can be influenced by maternal characteristics. This study describes HMO variation up to three months postpartum and explores the influences of maternal sociodemographic and anthropometric characteristics in a Brazilian prospective cohort. We followed 101 subjects from 28–35 gestational weeks (baseline) and throughout lactation at 2–8 (visit 1), 28–50 (visit 2) and 88–119 days postpartum (visit 3). Milk samples were collected at visits 1, 2 and 3, and 19 HMOs were quantified usinghigh-performance liquid chromatography with fluorescence detection (HPLC-FL). Friedman post-hoc test, Spearman rank correlation for maternal characteristics and HMOs and non-negative matrix factorization (NMF) were used to define the HMO profile. Most women were secretors (89.1%) and presented high proportion of 2′-fucosyllactose (2′FL) at all three sample times, while lacto-N-tetraose (LNT, 2–8 days) and lacto-N-fucopentaose II (LNFPII, 28–50 and 88–119 days) were the most abundant HMOs in non-secretor women. Over the course of lactation, total HMO weight concentrations (g/L) decreased, but total HMO molar concentrations (mmol/L) increased, highlighting differential changes in HMO composition over time. In addition, maternal pre-pregnancy body mass index (BMI) and parity influence the HMO composition in healthy women in this Brazilian cohort.


Virology ◽  
2017 ◽  
Vol 508 ◽  
pp. 81-89 ◽  
Author(s):  
Anna Koromyslova ◽  
Shailesh Tripathi ◽  
Vasily Morozov ◽  
Horst Schroten ◽  
Grant S. Hansman

2018 ◽  
Vol 148 (11) ◽  
pp. 1733-1742 ◽  
Author(s):  
Meghan B Azad ◽  
Bianca Robertson ◽  
Faisal Atakora ◽  
Allan B Becker ◽  
Padmaja Subbarao ◽  
...  

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