Gut dysbiosis correction contributes to the hepatoprotective effects of Thymus quinquecostatus Celak extract against alcohol through the gut–liver axis

2021 ◽  
Author(s):  
Xin Yan ◽  
Yu Wang ◽  
Xue-Yang Ren ◽  
Xiao-Yun Liu ◽  
Jia-Mu Ma ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Alcoholic Liver Injury ◽  
Gut Dysbiosis ◽  
Hepatoprotective Effects ◽  
Gut Microbiota Dysbiosis

Gut microbiota dysbiosis correction contributes to the hepatoprotective effects of Thymus quinquecostatus Celak extract (TQE) against alcoholic liver injury through gut–liver axis modulation.

Dietary nucleotides protect against alcoholic liver injury by attenuating inflammation and regulating gut microbiota in rats

2016 ◽  
Vol 7 (6) ◽  
pp. 2898-2908 ◽  
Author(s):  
Xiaxia Cai ◽  
Lei Bao ◽  
Nan Wang ◽  
Jinwei Ren ◽  
Qihe Chen ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Alcoholic Liver Injury ◽  
Dietary Nucleotides

The present study aims to investigate whether nucleotides ameliorate alcoholic liver injury and explores the possible mechanism.

Crosstalk between gut microbiota and host lipid metabolism in a mouse model of alcoholic liver injury by chronic baijiu or ethanol feeding

2022 ◽  
Author(s):  
Cheng Fang ◽  
Qingwu Zhou ◽  
Qingyang Liu ◽  
Wei Jia ◽  
Yan Xu
Keyword(s):  
Lipid Metabolism ◽  
Liver Injury ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Alcoholic Beverage ◽  
Alcoholic Liver Injury ◽  
Ethanol Feeding

This study demonstrates that compounds in baijiu, a traditional Chinese alcoholic beverage, can attenuate the development of ethanol-induced liver injury by regulating the crosstalk between gut microbiota and host lipid metabolism.

Antrodin A from Antrodia camphorata modulates the gut microbiome and liver metabolome in mice exposed to acute alcohol intake

2021 ◽  
Vol 12 (7) ◽  
pp. 2925-2937
Author(s):  
Zhenwei Yi ◽  
Xiaofeng Liu ◽  
Lihong Liang ◽  
Guangqiang Wang ◽  
Zhiqiang Xiong ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Alcohol Intake ◽  
Underlying Mechanism ◽  
Antrodia Camphorata ◽  
Hepatoprotective Effects

In this study, we investigated the hepatoprotective effects of AdA and the underlying mechanism at the liver metabolomics and gut microbiota levels under alcohol-induced liver injury conditions.

Fermented ginseng improved alcohol liver injury in association with changes in the gut microbiota of mice

2019 ◽  
Vol 10 (9) ◽  
pp. 5566-5573 ◽  
Author(s):  
Jingjing Fan ◽  
Yushan Wang ◽  
Ying You ◽  
Zhiyi Ai ◽  
Weichang Dai ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Intestinal Flora ◽  
Alcoholic Liver Injury ◽  
Fermented Ginseng

Fermented ginseng can alleviate alcoholic liver injury by adjusting the intestinal flora.

scholarly journals F. prausnitzii and its supernatant increase SCFAs-producing bacteria to restore gut dysbiosis in TNBS-induced colitis

AMB Express ◽  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Youlian Zhou ◽  
Haoming Xu ◽  
Jing Xu ◽  
Xue Guo ◽  
Hailan Zhao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Throughput Sequencing ◽  
Therapeutic Potential ◽  
Protective Effects ◽  
Trinitrobenzenesulfonic Acid ◽  
Gut Dysbiosis ◽  
Tnf Α ◽  
Inflammatory Bowel ◽  
Anti Inflammatory ◽  
Gut Microbiota Dysbiosis

AbstractAn increasing number of studies have shown that Faecalibacterium prausnitzii (F. prausnitzii) is a promising anti-inflammatory bacterium that colonizes in the gut and that gut microbiota dysbiosis plays an important role in the pathogenesis of inflammatory bowel disease (IBD). In this study, we report the gut microbiota profile of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis mice treated with F. prausnitzii and its supernatant on the basis of high-throughput sequencing. We interestingly found that both F. prausnitzii and its metabolites exerted protective effects against colitis in mice, which ameliorated gut dysbiosis, with an increase in bacterial diversity and the abundance of short-chain fatty acid (SCFA)-producing bacteria and a decrease in serum TNF-α and the abundance of Proteinbacteria, Acidobacteria, and Bacteroidetes. These findings will provide further evidence of the anti-inflammatory effect of F. prausnitzii, which presents therapeutic potential for IBD treatment.

scholarly journals Gut Microbiota Was Involved in the Process of Liver Injury During Intra-Abdominal Hypertension

2021 ◽  
Vol 12 ◽  
Author(s):  
Zeyu Zhao ◽  
Zhengchang Guo ◽  
Zhengliang Yin ◽  
Yue Qiu ◽  
Bo Zhou
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Intestinal Damage ◽  
Abdominal Hypertension ◽  
Portal Veins ◽  
The Relationship ◽  
Abdominal Compartment ◽  
Gut Microbiota Dysbiosis

Background: Intestinal damage caused by intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) can lead to the ectopic gut microbiota, which can contribute to liver injury via portal veins. Therefore, it is speculated that gut microbiota disorder caused by IAH/ACS may result in liver injury. The relationship between gut microbiota and IAH/ACS-related liver injury was investigated in this study.Methods: A model of IAH was established in rats, and 16S rRNA sequencing was analyzed for gut microbiota in the feces of rats. The elimination of gut microbiota was completed by antibiotics gavage, and fecal microbiota transplantation (FMT) was used to change the composition of gut microbiota in rats.Results: In addition to the traditional cause of liver blood vessel compression, liver injury caused by IAH was also associated with gut microbiota dysbiosis. Gut microbiota clearance can relieve liver injury caused by IAH, while FMT from IAH-intervened rats can aggravate IAH-related liver injury.Conclusion: The gut microbiota was one of the most important factors contributing to the IAH-related liver injury, and the JNK/p38 signaling pathway was activated in this process.

scholarly journals Scutellarein Aggravated Carbon Tetrachloride-Induced Chronic Liver Injury in Gut Microbiota-Dysbiosis Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Zhimin Miao ◽  
Yong Lai ◽  
Yingying Zhao ◽  
Lingmin Chen ◽  
Jianeng Zhou ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gut Microbiota ◽  
Relative Abundance ◽  
Function Analysis ◽  
Chronic Liver ◽  
Hepatoprotective Effect ◽  
Chronic Liver Injury ◽  
Cyp2e1 Expression ◽  
Factor Α ◽  
Gut Microbiota Dysbiosis

Scutellarein (SCU) is an herbal flavonoid, showing hepatoprotective potentials. The study was aimed to investigate whether the hepatoprotective effect of SCU is dependent on the integrity of gut microbiota. Mice received repeated intraperitoneal injections of CCl4, followed with or without SCU treatment (15, 30, and 60 mg/kg). Gut microbial community of mice was disrupted by administrating a cocktail of antibiotics (ampicillin, neomycin sulfate, metronidazole, and vancomycin) in drinking water. The results showed SCU plus antibiotics aggravated CCl4-induced chronic liver injury, as demonstrated by liver function analysis, histological analysis, and TUNEL assay. SCU activated CYP2E1 expression and worsened CYP2E1-mediated lipid peroxidation and oxidative stress as coadministered with antibiotics. Moreover, when gut microbiota was disrupted by antibiotics, SCU activated IκBα/NF-κB pathway and promoted the release of subsequent proinflammatory cytokines including interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α). Remarkably, the 16 S rRNA sequencing demonstrated that SCU greatly decreased the relative abundance of Bifidobacterium and Lactobacillus and increased the relative abundance of Enterococcus in gut microbiota-dysbiosis mice. Spearman correlation analysis showed that Lactobacillus was positively correlated with SOD and negatively correlated with AST. Collectively, the hepatoprotective effect of SCU is reversed under antibiotics intervention, which may partly involve the activation of CYP2E1 and IκBα/NF-κB pathway and diminishment of Lactobacillus.

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