In vivo wound healing efficiency of curcumin-incorporated pectin-chitosan biodegradable films

2021 ◽  
Author(s):  
V. Muthulakshmi ◽  
G. R. Rajarajeswari
Keyword(s):  
Thin Films ◽  
Wound Healing ◽  
Wound Dressing ◽  
Antibacterial Properties ◽  
Biodegradable Films ◽  
Healing Efficiency ◽  
Mechanical Barrier

Curcumin incorporated pectin/chitosan thin films application as a potential wound dressing material with good mechanical, barrier and antibacterial properties.

scholarly journals Correction: In vivo wound healing efficiency of curcumin-incorporated pectin-chitosan biodegradable films

2021 ◽  
Author(s):  
V. Muthulakshmi ◽  
G. R. Rajarajeswari
Keyword(s):  
Wound Healing ◽  
Biodegradable Films ◽  
Healing Efficiency

Correction for ‘In vivo wound healing efficiency of curcumin-incorporated pectin-chitosan biodegradable films’ by V. Muthulakshmi et al., New J. Chem., 2021, DOI: 10.1039/d1nj03477d.

Chitosan-based hydrogels prepared by UV polymerization for wound dressing

2019 ◽  
Vol 27 (3) ◽  
pp. 155-167 ◽  
Author(s):  
Han-Yun Yao ◽  
Hong-Ru Lin ◽  
Geng-Pin Sue ◽  
Yiu-Jiuan Lin
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Healing Rate ◽  
Antibacterial Properties ◽  
Hydroxyethyl Methacrylate ◽  
Biological Characterization ◽  
Hydrophilic Nature ◽  
Epidermal Growth

Chitosan-based hydrogels were prepared by grafting with poly(acrylic acid) (PAA) and poly(hydroxyethyl methacrylate) (pHEMA) through ultraviolet polymerization to further improve its hydrophilic nature and enhance its mechanical properties. The epidermal growth factor (EGF) was incorporated inside the hydrogels to stimulate the wound healing. The physical characterization of chitosan-PAA-pHEMA hydrogel indicates that it is highly hydrophilic with adequate properties for wound dressing purpose. The biological characterization shows that chitosan-based hydrogel retains its thrombogenic and antibacterial properties. The in vivo wound healing experiment demonstrates that the hydrogel-incorporated EGF has better wound healing rate than other dressings.

scholarly journals Effects of chitosan-collagen dressing on wound healing in vitro and in vivo assays

2021 ◽  
Vol 19 ◽  
pp. 228080002198969
Author(s):  
Min-Xia Zhang ◽  
Wan-Yi Zhao ◽  
Qing-Qing Fang ◽  
Xiao-Feng Wang ◽  
Chun-Ye Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Type I Collagen ◽  
Inhibition Zone ◽  
Negative Control ◽  
Type I ◽  
Nih3t3 Cells ◽  
Post Operation

The present study was designed to fabricate a new chitosan-collagen sponge (CCS) for potential wound dressing applications. CCS was fabricated by a 3.0% chitosan mixture with a 1.0% type I collagen (7:3(w/w)) through freeze-drying. Then the dressing was prepared to evaluate its properties through a series of tests. The new-made dressing demonstrated its safety toward NIH3T3 cells. Furthermore, the CCS showed the significant surround inhibition zone than empty controls inoculated by E. coli and S. aureus. Moreover, the moisture rates of CCS were increased more rapidly than the collagen and blank sponge groups. The results revealed that the CCS had the characteristics of nontoxicity, biocompatibility, good antibacterial activity, and water retention. We used a full-thickness excisional wound healing model to evaluate the in vivo efficacy of the new dressing. The results showed remarkable healing at 14th day post-operation compared with injuries treated with collagen only as a negative control in addition to chitosan only. Our results suggest that the chitosan-collagen wound dressing were identified as a new promising candidate for further wound application.

Preparation of biocompatible wound dressings with dual release of antibiotic and platelet-rich plasma for enhancing infected wound healing

2021 ◽  
pp. 088532822199601
Author(s):  
Linying Shi ◽  
Fang Lin ◽  
Mou Zhou ◽  
Yanhui Li ◽  
Wendan Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Wound Dressings ◽  
Inflammatory Factors ◽  
Gelatin Microspheres ◽  
Infected Wounds ◽  
Dual Release

The ever-growing threats of bacterial infection and chronic wound healing have provoked an urgent need for novel antibacterial wound dressings. In this study, we developed a wound dressing for the treatment of infected wounds, which can reduce the inflammatory period (through the use of gentamycin sulfate (GS)) and enhance the granulation stage (through the addition of platelet-rich plasma (PRP)). Herein, the sustained antimicrobial CMC/GMs@GS/PRP wound dressings were developed by using gelatin microspheres (GMs) loading GS and PRP, covalent bonding to carboxymethyl chitosan (CMC). The prepared dressings exhibited high water uptake capability, appropriate porosity, excellent mechanical properties, sustain release of PRP and GS. Meanwhile, the wound dressing showed good biocompatibility and excellent antibacterial ability against Gram-negative and Gram-positive bacteria. Moreover, in vivo experiments further demonstrated that the prepared dressings could accelerate the healing process of E. coli and S. aureus-infected full-thickness wounds i n vivo, reepithelialization, collagen deposition and angiogenesis. In addition, the treatment of CMC/GMs@GS/PRP wound dressing could reduce bacterial count, inhibit pro-inflammatory factors (TNF-α, IL-1β and IL-6), and enhance anti-inflammatory factors (TGF-β1). The findings of this study suggested that biocompatible wound dressings with dual release of GS and PRP have great potential in the treatment of chronic and infected wounds.

scholarly journals Photo-Crosslinked Polymeric Matrix with Antimicrobial Functions for Excisional Wound Healing in Mice

Nanomaterials ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 791 ◽  
Author(s):  
Ming-Hsiang Chang ◽  
Yu-Ping Hsiao ◽  
Chia-Yen Hsu ◽  
Ping-Shan Lai
Keyword(s):  
Wound Healing ◽  
Wound Infection ◽  
Polymer Solution ◽  
Wound Dressing ◽  
Glycol Diacrylate ◽  
Excisional Wound ◽  
Poly Ethylene ◽  
Systemic Infections

Wound infection extends the duration of wound healing and also causes systemic infections such as sepsis, and, in severe cases, may lead to death. Early prevention of wound infection and its appropriate treatment are important. A photoreactive modified gelatin (GE-BTHE) was synthesized by gelatin and a conjugate formed from the 3,3′,4,4′-benzophenone tetracarboxylic dianhydride (BTDA) and the 2-hydroxyethyl methacrylate (HEMA). Herein, we investigated the photocurable polymer solution (GE-BTHE mixture) containing GE-BTHE, poly(ethylene glycol) diacrylate (PEGDA), chitosan, and methylene blue (MB), with antimicrobial functions and photodynamic antimicrobial chemotherapy for wound dressing. This photocurable polymer solution was found to have fast film-forming property attributed to the photochemical reaction between GE-BTHE and PEGDA, as well as the antibacterial activity in vitro attributed to the ingredients of chitosan and MB. Our in vivo results also demonstrated that untreated wounds after 3 days had the same scab level as the GE-BTHE mixture-treated wounds after 20 s of irradiation, which indicates that the irradiated GE-BTHE mixture can be quickly transferred into artificial scabs to protect wounds from an infection that can serve as a convenient excisional wound dressing with antibacterial efficacy. Therefore, it has the potential to treat nonhealing wounds, deep burns, diabetic ulcers and a variety of mucosal wounds.

scholarly journals Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 389 ◽  
Author(s):  
Mónica C. Guadarrama-Acevedo ◽  
Raisa A. Mendoza-Flores ◽  
María L. Del Prado-Audelo ◽  
Zaida Urbán-Morlán ◽  
David M. Giraldo-Gomez ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Clinical Performance ◽  
Ex Vivo ◽  
High Capacity ◽  
Wound Dressings ◽  
In Vivo Studies ◽  
Potential Use

Non-biodegradable materials with a low swelling capacity and which are opaque and occlusive are the main problems associated with the clinical performance of some commercially available wound dressings. In this work, a novel biodegradable wound dressing was developed by means of alginate membrane and polycaprolactone nanoparticles loaded with curcumin for potential use in wound healing. Curcumin was employed as a model drug due to its important properties in wound healing, including antimicrobial, antifungal, and anti-inflammatory effects. To determine the potential use of wound dressing, in vitro, ex vivo, and in vivo studies were carried out. The novel membrane exhibited the diverse functional characteristics required to perform as a substitute for synthetic skin, such as a high capacity for swelling and adherence to the skin, evidence of pores to regulate the loss of transepidermal water, transparency for monitoring the wound, and drug-controlled release by the incorporation of nanoparticles. The incorporation of the nanocarriers aids the drug in permeating into different skin layers, solving the solubility problems of curcumin. The clinical application of this system would cover extensive areas of mixed first- and second-degree wounds, without the need for removal, thus decreasing the patient’s discomfort and the risk of altering the formation of the new epithelium.

scholarly journals Antibacterial-Integrated Collagen Wound Dressing for Diabetes-Related Foot Ulcers: An Evidence-Based Review of Clinical Studies

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2168
Author(s):  
Ibrahim N. Amirrah ◽  
Mohd Farhanulhakim Mohd Razip Wee ◽  
Yasuhiko Tabata ◽  
Ruszymah Bt Hj Idrus ◽  
Abid Nordin ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Trials ◽  
Clinical Studies ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Gentian Violet ◽  
Antibacterial Properties ◽  
Small Sample ◽  
Wound Dressings ◽  
Sample Sizes

Diabetic foot ulcer (DFU) is a chronic wound frequently delayed from severe infection. Wound dressing provides an essential barrier between the ulcer and the external environment. This review aimed to analyse the effectiveness of antibacterial collagen-based dressing for DFU treatment in a clinical setting. An electronic search in four databases, namely, Scopus, PubMed, Ovid MEDLINE(R), and ISI Web of Science, was performed to obtain relevant articles published within the last ten years. The published studies were included if they reported evidence of (1) collagen-based antibacterial dressing or (2) wound healing for diabetic ulcers, and (3) were written in English. Both randomised and non-randomised clinical trials were included. The search for relevant clinical studies (n) identified eight related references discussing the effectiveness of collagen-based antibacterial wound dressings for DFU comprising collagen impregnated with polyhexamethylene biguanide (n = 2), gentamicin (n = 3), combined-cellulose and silver (n = 1), gentian violet/methylene blue mixed (n = 1), and silver (n = 1). The clinical data were limited by small sample sizes and multiple aetiologies of chronic wounds. The evidence was not robust enough for a conclusive statement, although most of the studies reported positive outcomes for the use of collagen dressings loaded with antibacterial properties for DFU wound healing. This study emphasises the importance of having standardised clinical trials, larger sample sizes, and accurate reporting for reliable statistical evidence confirming DFU treatment efficiency.

In-Vivo Wound Healing Efficiency of Curcumin Loaded on Chitosan Polyvinyl Propylene Nanofilm

2016 ◽  
Vol 8 (10) ◽  
pp. 763-770 ◽  
Author(s):  
M. Ponnanikajamideen ◽  
S. Devi Priya ◽  
M. Vanaja ◽  
K. Paulkumar ◽  
S. Rajeshkumar ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Efficiency

Preparation and In Vivo Study of an Anti-Infective Highly Volatile Wound Dressing Material

2010 ◽  
Vol 123-125 ◽  
pp. 355-358
Author(s):  
Mubarak A. Khan ◽  
Jahid M.M. Islam ◽  
Md. Arifur Rahman ◽  
H.U. Shekhar
Keyword(s):  
Wound Healing ◽  
Rattus Norvegicus ◽  
Wound Dressing ◽  
Ventral Side ◽  
Gelatin Solution ◽  
Spray System ◽  
High Volatility ◽  
Healing Wounds ◽  
Antibiotic Dosing

In this research, a highly volatile membrane forming solution of gelatin with quick membrane forming property (30 sec) was prepared to investigate the suitability of solution spray system in the treatment of wound at dermal surface. A nontoxic Aromatic Ketone (AK) and a highly volatile solvent (VS) were introduced in gelatin solution to ensure high volatility. The solution was subjected to antibiotic dosing using Ciprofloxacin to ensure its anti-infectiveness. The pH of the raw gelatin solution and the highly volatile gelatin solution were 4.95 and 6.17 respectively. Viscosity of gelatin/AK/VS solution was 62.12mPa.s. Wound healing characteristic of the highly volatile solution (gelatin/AK/VS) was evaluated using a rat (Rattus norvegicus) model. Full-thickness wounds were created on the ventral side of the Rattus norvegicus and were dressed with the volatile solution and “eco-plaster” (control). Wound healing and bioadhesion were monitored in 3-days interval. The results revealed that prepared volatile solution was more effective in preventing blood loss as well as healing wounds than the conventional wound dresser.

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