Derivatization based on tetrazine scaffold: synthesis of tetrazine derivatives and their biomedical applications

2021 ◽  
Author(s):  
Hongbao Sun ◽  
Qinghe Xue ◽  
Chang Zhang ◽  
Haoxing Wu ◽  
Ping Feng
Keyword(s):  
Biomedical Applications ◽  
Chemical Biology ◽  
Biological Systems ◽  
Bioorthogonal Chemistry ◽  
Bioorthogonal Reactions

Bioorthogonal chemistry is widely used in biological systems and has been trialed in patients, attracting a lot of attention in this century. Tetrazine-based bioorthogonal reactions are essential in chemical biology...

scholarly journals Nanoparticles and bioorthogonal chemistry joining forces for improved biomedical applications

2021 ◽  
Author(s):  
Javier Idiago-López ◽  
Eduardo Moreno-Antolín ◽  
Jesús M. de la Fuente ◽  
Raluca M. Fratila
Keyword(s):  
Biomedical Applications ◽  
Bioorthogonal Chemistry ◽  
Bioorthogonal Reactions

Herein, we summarise the recent efforts to bring together the unique properties of nanoparticles and the remarkable features of bioorthogonal reactions for creating a toolbox of new or improved biomedical applications.

scholarly journals Impact of anti-biofouling surface coatings on the properties of nanomaterials and their biomedical applications

2018 ◽  
Vol 6 (1) ◽  
pp. 9-24 ◽  
Author(s):  
Yuancheng Li ◽  
Yaolin Xu ◽  
Candace C. Fleischer ◽  
Jing Huang ◽  
Run Lin ◽  
...  
Keyword(s):  
Surface Coating ◽  
Biomedical Applications ◽  
Biological Systems ◽  
Surface Coatings ◽  
Specific Interactions ◽  
Coating Materials

Various anti-biofouling surface coating materials for nanoparticles have been reviewed for the reduction of their non-specific interactions with biological systems.

7 Tetrazine-Based Cycloadditions in Click Chemistry

2022 ◽  
Author(s):  
W. Kuba ◽  
M. Wilkovitsch ◽  
J. C. T. Carlson ◽  
H. Mikula
Keyword(s):  
Reaction Mechanisms ◽  
Chemical Biology ◽  
Bond Cleavage ◽  
Therapeutic Strategies ◽  
Complex Environments ◽  
Bioorthogonal Chemistry ◽  
Bioorthogonal Reaction ◽  
Low Concentrations ◽  
Time Critical

AbstractThe spontaneous cycloaddition of tetrazines with a number of different dienophiles has become a powerful tool in chemical biology, in particular for the biocompatible conjugation and modification of (bio)molecules. The exceptional reaction kinetics made these bioorthogonal ligations the methods of choice for time-critical processes at very low concentrations, facilitating controlled molecular transformations in complex environments and even in vivo. The emerging concept of bond-cleavage reactions triggered by tetrazine-based cycloadditions enabled the design of diagnostic and therapeutic strategies. The tetrazine-triggered activation of prodrugs represents the first bioorthogonal reaction performed in humans, marking the beginning of the era of clinical translation of bioorthogonal chemistry. This chapter provides an overview of the synthesis and reactivity of tetrazines, their cycloadditions with various dienophiles, and transformations triggered by these reactions, focusing on reaction mechanisms, kinetics and efficiency, and selected applications.

Reductive Amination/Alkylation Reactions: The Recent Developments, Progresses, and Applications in Protein Chemical Biology Studies

2018 ◽  
Vol 15 (6) ◽  
pp. 755-761 ◽  
Author(s):  
Zhipeng A. Wang ◽  
Yan-Yu Liang ◽  
Ji-Shen Zheng
Keyword(s):  
Chemical Biology ◽  
Reductive Amination ◽  
High Efficiency ◽  
Protein Complexes ◽  
Protein Chemistry ◽  
Bioorthogonal Reactions ◽  
Chemistry Research ◽  
Amination Reaction ◽  
Recent Developments ◽  
Alkylation Reactions

The chemical modifications of proteins or protein complexes have been a challenging but fruitful task in the post-genomic era. Bioorthogonal reactions play an important role for the purpose of selective functionalization, localization, and labeling of proteins with natural or non-natural structures. Among these reactions, reductive amination stands out as one of the typical bioorthogonal reactions with high efficiency, good biocompatibility, and versatile applications. However, not many specific reviews exist to discuss the mechanism, kinetics, and their applications in a detailed manner. In this manuscript, we aim to summarize some current developments and mechanistic studies of reductive amination reaction and its applications. We hope reductive amination reaction can contribute to a wider scope of protein chemistry research en route in the chemical biology frontier as one of the well-known bioorthogonal reactions.

Potential Role of Biological Systems in Formation of Nanoparticles: Mechanism of Synthesis and Biomedical Applications

2013 ◽  
Vol 9 (5) ◽  
pp. 576-587 ◽  
Author(s):  
Mahendra Rai ◽  
Avinash Ingle ◽  
Indarchand Gupta ◽  
Sonal Birla ◽  
Alka Yadav ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Potential Role ◽  
Biological Systems

Biology-guided engineering of bioelectrical interfaces

2022 ◽  
Author(s):  
Bernadette A. Miao ◽  
Lingyuan Meng ◽  
Bozhi Tian
Keyword(s):  
Biomedical Applications ◽  
Biological Systems ◽  
Design Engineering ◽  
Recent Advances ◽  
Microbial Systems

This review provides an overview and recent advances of how biological systems guide the design, engineering, and implementation of bioelectrical interfaces for biomedical applications in nervous, cardiac, and microbial systems.

scholarly journals Inverse electron demand Diels–Alder reactions in chemical biology

2017 ◽  
Vol 46 (16) ◽  
pp. 4895-4950 ◽  
Author(s):  
B. L. Oliveira ◽  
Z. Guo ◽  
G. J. L. Bernardes
Keyword(s):  
Chemical Biology ◽  
Diels Alder ◽  
Inverse Electron Demand ◽  
Bioorthogonal Reactions ◽  
Electron Demand

The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and biocompatibility.

Cyclopropenes: a new tool for the study of biological systems

2017 ◽  
Vol 4 (6) ◽  
pp. 1167-1198 ◽  
Author(s):  
João M. J. M. Ravasco ◽  
Carlos M. Monteiro ◽  
Alexandre F. Trindade
Keyword(s):  
Chemical Biology ◽  
Biological Systems ◽  
Diels Alder ◽  
Inverse Electron Demand ◽  
Electron Demand

Cyclopropenes have become an important mini-tag tool in chemical biology, participating in fast inverse electron demand Diels–Alder and photoclick reactions in biological settings.

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