Changes in the metabolism of inositol phospholipids with myoblast fusion

1981 ◽  
Vol 9 (5) ◽  
pp. 462-463
Author(s):  
MICHAEL J. O. WAKELAM ◽  
DIRK PETTE
Keyword(s):  
Myoblast Fusion ◽  
Inositol Phospholipids

scholarly journals TGFβ signalling acts as a molecular brake of myoblast fusion

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Julie Melendez ◽  
Daniel Sieiro ◽  
David Salgado ◽  
Valérie Morin ◽  
Marie-Julie Dejardin ◽  
...  
Keyword(s):  
Dynamic Control ◽  
Muscle Growth ◽  
Myoblast Fusion ◽  
In Vivo Studies ◽  
In Vitro Assays ◽  
Receptor Complex ◽  
Tgfβ Signalling ◽  
Molecular Brake

AbstractFusion of nascent myoblasts to pre-existing myofibres is critical for skeletal muscle growth and repair. The vast majority of molecules known to regulate myoblast fusion are necessary in this process. Here, we uncover, through high-throughput in vitro assays and in vivo studies in the chicken embryo, that TGFβ (SMAD2/3-dependent) signalling acts specifically and uniquely as a molecular brake on muscle fusion. While constitutive activation of the pathway arrests fusion, its inhibition leads to a striking over-fusion phenotype. This dynamic control of TGFβ signalling in the embryonic muscle relies on a receptor complementation mechanism, prompted by the merging of myoblasts with myofibres, each carrying one component of the heterodimer receptor complex. The competence of myofibres to fuse is likely restored through endocytic degradation of activated receptors. Altogether, this study shows that muscle fusion relies on TGFβ signalling to regulate its pace.

scholarly journals Mechanisms of myoblast fusion during muscle development

2015 ◽  
Vol 32 ◽  
pp. 162-170 ◽  
Author(s):  
Ji Hoon Kim ◽  
Peng Jin ◽  
Rui Duan ◽  
Elizabeth H Chen
Keyword(s):  
Muscle Development ◽  
Myoblast Fusion

scholarly journals Visualizing new dimensions inDrosophila myoblast fusion

BioEssays ◽  
2008 ◽  
Vol 30 (5) ◽  
pp. 423-431 ◽  
Author(s):  
Brian Richardson ◽  
Karen Beckett ◽  
Mary Baylies
Keyword(s):  
Myoblast Fusion

scholarly journals Nuclear phosphoinositide kinases and inositol phospholipids

2006 ◽  
Vol 97 (2) ◽  
pp. 252-260 ◽  
Author(s):  
Michael L. Gonzales ◽  
Richard A. Anderson
Keyword(s):  
Inositol Phospholipids
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