Expression of Concern: Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker Fatty Rats

2020 ◽  
Vol 134 (21) ◽  
pp. 2789-2789
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Green Tea ◽  
Insulin Signalling ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Metabolic Abnormalities

Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker fatty rats

2020 ◽  
Vol 134 (10) ◽  
pp. 1167-1180
Author(s):  
Jing Cheng ◽  
Yi Tan ◽  
Jiong Zhou ◽  
Linda Xiao ◽  
Michael Johnson ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Body Weight ◽  
Insulin Sensitivity ◽  
Glucose Uptake ◽  
Green Tea ◽  
Visceral Fat ◽  
Insulin Signalling ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols

Abstract In the present study, we evaluated the metabolic effects of green tea polyphenols (GTPs) in high-fat diet (HFD) fed Zucker fatty (ZF) rats, in particular the effects of GTP on skeletal muscle insulin sensitivity. Body weight, visceral fat, glucose tolerance, lipid profiles and whole-body insulin sensitivity were measured in HFD-fed ZF rats after 8-week-treatment with GTP (200 mg/kg of body weight) or saline (5 ml/kg of body weight). Zucker lean rats were studied as controls. Ex vivo insulin-mediated muscle glucose uptake was assessed. Immunoblotting was used to evaluate the expression of key insulin signalling proteins in skeletal muscle. GTP treatment attenuated weight gain (P<0.05) and visceral fat accumulation (27.6%, P<0.05), and significantly reduced fasting serum glucose (P<0.05) and insulin (P<0.01) levels. Homoeostasis model assessment of insulin resistance (HOMA-IR), a measure of insulin resistance, was lower (P<0.01) in GTP-treated animals compared with ZF controls. Moreover, insulin-stimulated glucose uptake by isolated soleus muscle was increased (P<0.05) in GTP-ZF rats compared with ZF-controls. GTP treatment attenuated the accumulation of ectopic lipids (triacyl- and diacyl-glycerols), enhanced the expression and translocation of glucose transporter-4, and decreased pSer612IRS-1 and increased pSer473Akt2 expression in skeletal muscle. These molecular changes were also associated with significantly decreased activation of the inhibitory (muscle-specific) protein kinase (PKC) isoform, PKC-θ. Taken together, the present study has shown that regular ingestion of GTP exerts a number of favourable metabolic and molecular effects in an established animal model of obesity and insulin resistance. The benefits of GTP are mediated in part by inhibiting PKC-θ and improving muscle insulin sensitivity.

A mixture of citrus polymethoxyflavones, green tea polyphenols and lychee extracts attenuates adipogenesis in 3T3-L1 adipocytes and obesity-induced adipose inflammation in mice

2019 ◽  
Vol 10 (12) ◽  
pp. 7667-7677 ◽  
Author(s):  
Min-Hsiung Pan ◽  
Ming-Yi Li ◽  
Mei-Ling Tsai ◽  
Chih-Yu Pan ◽  
Vladimir Badmaev ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Green Tea ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Adipose Inflammation

Adipocyte–macrophage interaction in obesity can cause adipose tissue inflammation and contribute to insulin resistance.

Topical Green Tea Polyphenols and Caffeine as a Treatment for Acne Vulgaris

2017 ◽  
Vol 1 ◽  
pp. s55
Author(s):  
Sarah Y Siu ◽  
Georgina M Ferzli ◽  
Neil Brody
Keyword(s):  
Green Tea ◽  
Acne Vulgaris ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols

Abstract Not Available

Antimutagenic activity of green tea polyphenols

1989 ◽  
Vol 223 (3) ◽  
pp. 273-285 ◽  
Author(s):  
Zhi Y. Wang ◽  
Shu J. Cheng ◽  
Zong C. Zhou ◽  
Mohammad Athar ◽  
Wasiuddin A. Khan ◽  
...  
Keyword(s):  
Green Tea ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Antimutagenic Activity

Supplementation with Green Tea Polyphenols Improves Bone Microstructure and Quality in Aged, Orchidectomized Rats

2011 ◽  
Vol 88 (6) ◽  
pp. 455-463 ◽  
Author(s):  
Chwan-Li Shen ◽  
Jay J. Cao ◽  
Raul Y. Dagda ◽  
Thomas E. Tenner ◽  
Ming-Chien Chyu ◽  
...  
Keyword(s):  
Green Tea ◽  
Bone Microstructure ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols

Complexation/encapsulation of green tea polyphenols in mixed calcium carbonate and phosphate micro-particles

2010 ◽  
Vol 28 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Amal Elabbadi ◽  
Nicolas Jeckelmann ◽  
Olivier P. Haefliger ◽  
Lahoussine Ouali
Keyword(s):  
Calcium Carbonate ◽  
Green Tea ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Micro Particles
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