The Effect of Simulated Metabolic Acidosis on Intracellular pH and Lactate Metabolism in the Isolated Perfused Rat Liver
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1. The relationship between extracellular pH (pHe), intracellular pH (pHi) and lactate uptake was studied in the isolated perfused rat liver during simulated metabolic acidosis. 2. pHi fell to a considerably less extent than pHe when the latter was decreased from pH 7·4 to 6·7. 3. The liver took up lactate when pHi was greater than 7·0; at lower values of pHi lactate output occurred. 4. The relevance of these observations to the control of hepatic pHi and lactate metabolism is discussed.
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2006 ◽
Vol 119
(3)
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pp. 1013-1028
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1971 ◽
Vol 27
(5)
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pp. 543-543
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1969 ◽
Vol 244
(23)
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pp. 6451-6457
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1991 ◽
Vol 372
(1)
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pp. 401-410
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1982 ◽
Vol 47
(02)
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pp. 166-172
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