In utero programming of chronic disease

1998 ◽  
Vol 95 (2) ◽  
pp. 115-128 ◽  
Author(s):  
D. J. P. BARKER
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chronic Disease ◽  
Later Life ◽  
In Utero ◽  
Human Fetuses ◽  
Limited Supply ◽  
Structure And Metabolism

1.Many human fetuses have to adapt to a limited supply of nutrients. In doing so they permanently change their structure and metabolism. 2.These ‘programmed' changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders stroke, diabetes and hypertension. 3.This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area.

scholarly journals Is Childhood Socioeconomic Status Related to Coronary Heart Disease? Evidence From the Health and Retirement Study (1992-2012)

2017 ◽  
Vol 3 ◽  
pp. 233372141769667 ◽  
Author(s):  
Minjee Lee ◽  
M. Mahmud Khan ◽  
Brad Wright
Keyword(s):  
Socioeconomic Status ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Later Life ◽  
Study Data ◽  
Health And Retirement Study ◽  
Increased Risk ◽  
Childhood Socioeconomic Status ◽  
Nationally Representative ◽  
Retirement Study

Objective: We investigated the association between childhood socioeconomic status (SES) and coronary heart disease (CHD) in older Americans. Method: We used Health and Retirement Study data from 1992 to 2012 to examine a nationally representative sample of Americans aged ≥50 years ( N = 30,623). We modeled CHD as a function of childhood and adult SES using maternal and paternal educational level as a proxy for childhood SES. Results: Respondents reporting low childhood SES were significantly more likely to have CHD than respondents reporting high childhood SES. Respondents reporting both low childhood and adult SES were 2.34 times more likely to have CHD than respondents reporting both high childhood and adult SES. People with low childhood SES and high adult SES were 1.60 times more likely than people with high childhood SES and high adult SES to report CHD in the fully adjusted model. High childhood SES and low adult SES increased the likelihood of CHD by 13%, compared with high SES both as a child and adult. Conclusion: Childhood SES is significantly associated with increased risk of CHD in later life among older adult Americans.

scholarly journals Associations Between Midlife (but Not Late-Life) Elevated Coronary Heart Disease Risk and Lower Cognitive Performance: Results From the Framingham Offspring Study

2019 ◽  
Vol 188 (12) ◽  
pp. 2175-2187 ◽  
Author(s):  
Nicole M Armstrong ◽  
Katherine J Bangen ◽  
Rhoda Au ◽  
Alden L Gross
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Executive Function ◽  
Cognitive Performance ◽  
Late Life ◽  
Later Life ◽  
Cognitive Change ◽  
Carrier Status ◽  
Allele Carrier ◽  
Chd Risk

Abstract It is unclear how coronary heart disease (CHD) risk across the adult life span affects late-life cognition. We estimated associations of midlife and late-life elevated CHD risk with cognitive trajectories (general cognitive performance, processing speed/executive function, memory) in later life (after age 55 years or age 70 years) among 2,892 Framingham Offspring Study participants who had completed CHD risk assessments approximately every 4 years since 1971 and had undergone neuropsychological testing between 1999 and 2014. We stratified analyses by apolipoprotein E gene (APOE) Ɛ4 allele carrier status. Using linear mixed-effects models, elevated CHD risk in midlife (age 55 years) was associated with lower levels of general cognitive performance (β = −0.560 standard deviation (SD) units, 95% confidence interval (CI): −0.874, −0.246), executive function (β = −0.624 SD units, 95% CI: −0.916, −0.332), and memory (β = −0.560 SD units, 95% CI: −0.907, −0.213) at age 70 years but not with rates of cognitive change. Late-life (age 70 years) elevated CHD risk, however, was associated with somewhat better levels of general cognitive performance and memory. There were associations between duration of elevated CHD risk during midlife and levels (but not trajectories) of later-life cognitive outcomes. Associations were not modified by APOE-ɛ4 status. These findings suggest that midlife elevated CHD risk is associated with lower cognition, independently of APOE-ɛ4 status, suggesting that risk of vascular disease may not contribute a “second hit” to AD risk.

scholarly journals Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study

BMJ ◽  
1997 ◽  
Vol 315 (7119) ◽  
pp. 1342-1348 ◽  
Author(s):  
S A Stanner ◽  
K Bulmer ◽  
C Andres ◽  
O E Lantseva ◽  
V Borodina ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cross Sectional Study ◽  
In Utero ◽  
Sectional Study ◽  
Cross Sectional

Growth In Utero and During Childhood Among Women Who Develop Coronary Heart Disease: Longitudinal Study

2000 ◽  
Vol 55 (5) ◽  
pp. 280-281
Author(s):  
T. Forsén ◽  
J. G. Eriksson ◽  
J. Tuomilehto ◽  
C. Osmond ◽  
D. J. P. Barker
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Longitudinal Study ◽  
In Utero

Mediterranean Diet Polyphenols: Anthocyanins and their Implications for Health

2020 ◽  
Vol 21 ◽  
Author(s):  
Simona Martinotti ◽  
Gregorio Bonsignore ◽  
Mauro Patrone ◽  
Elia Ranzato
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chronic Disease ◽  
Cardiovascular Diseases ◽  
Mortality Rate ◽  
Mediterranean Diet ◽  
Dairy Products ◽  
Mediterranean Area ◽  
Herbal Remedies ◽  
Food Regime

Abstract:: The Mediterranean diet (MD) is becoming a milestone for the prevention of chronic disease, such as cardiovascular diseases (CVDs), Alzheimer’s and Parkinson’s disease. Ancel Keys in the 1950’s showed a low mortality rate, in particular for coronary heart disease, among people resident in Mediterranean area. The MD is characterized by the intake of high amount of vegetables, fruit and cereals and regular but moderate consumption of wine, fish and dairy products, while olive oil is the main source of culinary fat. Therefore, it is principally a plant-based diet rich in polyphenols, a heterogeneous category of compounds with different properties and bio availabilities. Among polyphenols, anthocyanins have been combined into the human food regime for centuries and have been utilized as traditional herbal remedies for their abilities to treat several conditions, as potent anti-oxidants, anti-diabetic and anti-carcinogenic compounds. This reviews summarizes our knowledge on the health-enhancing component of anthocyanins-rich diet.

Sign in / Sign up

Export Citation Format

Share Document