Role of signal transduction pathway of mitogen-activated protein kinase on metastasis of hepatocellular carcinoma induced by VEGF

2001 ◽  
Vol 2 (1) ◽  
pp. 38-41
Author(s):  
Mao Hua ◽  
Yuan Aili ◽  
Zhao Minfang ◽  
Lai Zuosheng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Signal Transduction ◽  
Protein Kinase ◽  
Signal Transduction Pathway ◽  
Mitogen Activated Protein Kinase ◽  
Transduction Pathway ◽  
Mitogen Activated Protein

Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes

1993 ◽  
Vol 13 (9) ◽  
pp. 5659-5669 ◽  
Author(s):  
M Tyers ◽  
B Futcher
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Signal Transduction Pathway ◽  
Mitogen Activated Protein Kinase ◽  
G1 Phase ◽  
Transduction Pathway ◽  
Yeast Saccharomyces Cerevisiae ◽  
Alpha Factor ◽  
Mitogen Activated Protein

In the yeast Saccharomyces cerevisiae, the Cdc28 protein kinase controls commitment to cell division at Start, but no biologically relevant G1-phase substrates have been identified. We have studied the kinase complexes formed between Cdc28 and each of the G1 cyclins Cln1, Cln2, and Cln3. Each complex has a specific array of coprecipitated in vitro substrates. We identify one of these as Far1, a protein required for pheromone-induced arrest at Start. Treatment with alpha-factor induces a preferential association and/or phosphorylation of Far1 by the Cln1, Cln2, and Cln3 kinase complexes. This induced interaction depends upon the Fus3 protein kinase, a mitogen-activated protein kinase homolog that functions near the bottom of the alpha-factor signal transduction pathway. Thus, we trace a path through which a mitogen-activated protein kinase regulates a Cdc2 kinase.

Clozapine and the mitogen-activated protein kinase signal transduction pathway: Implications for antipsychotic actions

2005 ◽  
Vol 57 (6) ◽  
pp. 617-623 ◽  
Author(s):  
Jeff L. Browning ◽  
Tushar Patel ◽  
Paul C. Brandt ◽  
Keith A. Young ◽  
Leigh A. Holcomb ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Signal Transduction Pathway ◽  
Mitogen Activated Protein Kinase ◽  
Transduction Pathway ◽  
Mitogen Activated Protein
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