Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis

2002 ◽  
Vol 16 (1) ◽  
pp. 66-67 ◽  
Author(s):  
S Piskin ◽  
C Sayan ◽  
N Durukan ◽  
M Senol
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Serum Iron ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis

Significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high homocysteine level with recurrent aphthous stomatitis

2014 ◽  
Vol 44 (4) ◽  
pp. 300-305 ◽  
Author(s):  
Andy Sun ◽  
Hsin-Ming Chen ◽  
Shih-Jung Cheng ◽  
Yi-Ping Wang ◽  
Julia Yu-Fong Chang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Homocysteine Level ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis

A Case Report of Pernicious Anemia and Recurrent Aphthous Stomatitis

2009 ◽  
Vol 10 (2) ◽  
pp. 83-89 ◽  
Author(s):  
Ricardo Alves Mesquita ◽  
Bruna Gonçalves Garcia ◽  
Marcelo Ferreira Pinto Cardoso ◽  
Omar de Faria ◽  
Ricardo Santiago Gomez
Keyword(s):  
Folic Acid ◽  
Case Report ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Systemic Disease ◽  
Intrinsic Factor ◽  
Serum Vitamin ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Vitamin B12 Malabsorption

Abstract Aim The aim of this report is to present the management of a patient with pernicious anemia afflicted with recurrent aphthous stomatitis (RAS). Background RAS is one of the most common lesions of the oral mucosa. Although the exact etiology of RAS is still unknown different hematinic deficiencies have been proposed. Case Report Painful recurrent ulcers covered with a grayish pseudomembrane surrounded by an erythematous margin were identified on the tongue and in the buccal mucosa of a 71-year-old woman. The patient also presented with depapilation of the tongue. The clinical diagnosis was RAS. Laboratory tests including a hemogram were ordered to determine existing levels of folic acid, iron, ferritin, and vitamins B2, B6, and B12. Levels of serum vitamin B12 and serum hemoglobin were low. The laboratory investigation also showed a medium corpuscular volume of 104.1 fl. A gastroduodenoscopy revealed no macroscopic abnormality. A gastric biopsy showed mucosal atrophy in the gastric corpus with evidence of intestinal metaplasia. Antibodies against an intrinsic factor were negative. The diagnosis pernicious anemia was made, with RAS caused by vitamin B12 malabsorption. Treatment consisted of the administration of 1.0 ml of hydroxocolabamin intramuscularly twice weekly over four weeks followed by 1.0 ml once weekly for four weeks. Clinical resolution was observed after two months. Summary The association of RAS with vitamin B12 malabsorption is a rare event. However, along with conventional RAS clinical management, iron, folic acid, vitamin B deficiencies, and nutritional intolerance must be considered. Evaluation of the predisposing factors is imperative in treating patients with RAS including vitamin B12 malabsorption. Clinical Significance Determination of the levels of vitamin B12 should be the basis for replacement therapy. Such therapy can be considered a benefit to the patients with RAS as its etiology remains unclear. Clinicians must be alert to the possibility this lesion could be a signal of systemic disease. Citation Garcia BG, Cardoso MFP, Faria O, Gomez RS, Mesquita RA. A Case Report of Pernicious Anemia and Recurrent Aphthous Stomatitis. J Contemp Dent Pract 2009 March; (10)2:083-089.

scholarly journals Recurrent Aphthous Stomatitis and Nutritional Deficiencies: Report of Three Cases with Literature Review

2019 ◽  
pp. 93-103
Author(s):  
Yadira V. Boza Oreamuno DDS, MSc ◽  
María F. Rugama Flores BSND
Keyword(s):  
Folic Acid ◽  
Iron Deficiency ◽  
Vitamin B12 ◽  
Systemic Disease ◽  
Recurrent Aphthous Stomatitis ◽  
Blood Analysis ◽  
Aphthous Stomatitis ◽  
Vegan Diet ◽  
Nutritional Deficiencies ◽  
First Case

Introduction: Recurrent aphthous stomatitis (RAS) is the most common ulcerative disease that affects the non-keratinized oral mucosa. The etiology is still unknown, but several local and systemic factors have been proposed as causal agents. Case description: three patients are reported with RAS associated with nutritional deficiencies, due to dietary restriction diets. The first case, a 19-year-old woman with iron deficiency, reported taking green tea daily and consuming a small amount of carbohydrates, fats and meat. The second case, a 32-year-old man with iron deficiency and vitamin B12 associated with vegan diet, although sometimes if he consumed meat. The third case, man of 50 years, vegan and ex-smoker for a year, presented deficiency of iron, vitamin B12 and folic acid. In all three cases a detailed questioning, clinical examination and complete blood analysis allowed to establish an adequate diagnosis, dental management and referral with a nutritionist, in order to treat the underlying pathology and not only provide a symptomatic treatment of the injuries. Discussion: In the setting of RAS, it is advisable to perform an analysis that includes a blood count, folic acid, iron and vitamin B12, to rule out possible systemic causes and eventually treat them. Clinical management aims to improve patient function and quality of life through topical and systemic therapies; however, it is essential to identify and control the causal factors that contribute; as well as, the exclusion or treatment of the underlying systemic disease.

scholarly journals Serum vitamin B12 associated with vitamin D/25(OH)D in women with recurrent aphthous stomatitis.

2020 ◽  
Vol 9 (1) ◽  
pp. 21-28
Author(s):  
Hendri Susanto ◽  
◽  
Puput Kendarwati ◽  
Sri Budiarti ◽  
Supriatno . ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis
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