scholarly journals Fibroblast Growth Factor 23 and Sudden Versus Non-sudden Cardiac Death: The Cardiovascular Health Study

2015 ◽  
Vol 66 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Rajat Deo ◽  
Ronit Katz ◽  
Ian H. de Boer ◽  
Nona Sotoodehnia ◽  
Bryan Kestenbaum ◽  
...  
2014 ◽  
Vol 237 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Vincent M. Brandenburg ◽  
Marcus E. Kleber ◽  
Marc G. Vervloet ◽  
Andreas Tomaschitz ◽  
Stefan Pilz ◽  
...  

Bone ◽  
2018 ◽  
Vol 114 ◽  
pp. 278-284 ◽  
Author(s):  
Rupal Mehta ◽  
Xuan Cai ◽  
Alexander Hodakowski ◽  
Bharat Thyagarajan ◽  
Donglin Zeng ◽  
...  

Heart Rhythm ◽  
2013 ◽  
Vol 10 (10) ◽  
pp. 1425-1432 ◽  
Author(s):  
Ayman A. Hussein ◽  
John S. Gottdiener ◽  
Traci M. Bartz ◽  
Nona Sotoodehnia ◽  
Christopher DeFilippi ◽  
...  

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Larisa G Tereshchenko ◽  
Jonathan Waks ◽  
Mary Biggs ◽  
Colleen Sitlani ◽  
Muammar Kabir ◽  
...  

Introduction: Electrocardiographic (ECG) measures of myocardial global electrical heterogeneity (GEH) are associated with sudden cardiac death (SCD) in middle-age adults. Hypothesis: We hypothesized that time-updated ECG GEH measures are associated with SCD in elderly adults after LVEF adjustment. Methods: We analyzed data from 2 prospective cohorts: The Atherosclerosis Risk in Communities (ARIC, n=15,366; mean age 54.1±5.8 y; 44.6% male; 73.2% white) and the Cardiovascular Health Study (CHS, n=5,016; mean age 72.8±5.6 y; 43.1% male; 95.3% white). Mean spatial QRS-T angle, azimuth, elevation, and magnitude of spatial ventricular gradient (SVG), and sum absolute QRST integral (SAI QRST) were calculated from digital 12-lead ECGs and analyzed as baseline variables in ARIC and as time-updated longitudinal variables in CHS (measured yearly at 10 consecutive visits). The primary outcome was adjudicated SCD. Cox regression models were constructed: Model 1 adjusted for age, sex and race. Model 2 further adjusted for cardiovascular disease, beta-blocker use, creatinine, BMI, hypertension, diabetes, smoking, total cholesterol, HDL, triglycerides, physical activity and alcohol use. Model 3 included Model 2 variables and heart rate, QTc, LV hypertrophy and bundle branch block or intra-ventricular conduction delay. Model 4 in CHS included all Model 3 variables plus baseline LVEF and time-updated incident HF and coronary heart disease. Results: During median 13-14 y of follow-up SCD incidence was 1.51 (95%CI 1.35-1.69) per 1,000 person-yrs in ARIC, and 2.78 (95%CI 2.41-3.21) per 1,000 person-yrs in CHS. In both cohorts (Table) QRS-T angle, SVG and SAI QRST were associated with SCD. Among older adults (CHS), longitudinal SAI QRST, QRS-T angle and SVG magnitude were associated with SCD independent of LVEF. Conclusions: Baseline and longitudinal GEH ECG parameters are independently associated with SCD in middle-age and older adults, respectively. In older adults, GEH ECG parameters provide information on SCD risk beyond LVEF.


Heart Rhythm ◽  
2011 ◽  
Vol 8 (2) ◽  
pp. 228-233 ◽  
Author(s):  
Kristen K. Patton ◽  
Nona Sotoodehnia ◽  
Christopher DeFilippi ◽  
David S. Siscovick ◽  
John S. Gottdiener ◽  
...  

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