Monocyte-derived macrophage cytokine responses induced by M. bovis BCG

2000 ◽  
Vol 80 (4-5) ◽  
pp. 197-207 ◽  
Author(s):  
S. Atkinson ◽  
E. Valadas ◽  
S.M. Smith ◽  
P.T. Lukey ◽  
H.M. Dockrell
Keyword(s):  
Cytokine Responses ◽  
Macrophage Cytokine

Cigarette Smoke Alters Alveolar Macrophage Cytokine Responses To Bacteria In A Murine Model

2011 ◽  
Author(s):  
Jake K. Nikota ◽  
Gordon J. Gaschler ◽  
Pamela Shen ◽  
Carole Yauk ◽  
Andrew Williams ◽  
...  
Keyword(s):  
Alveolar Macrophage ◽  
Cigarette Smoke ◽  
Murine Model ◽  
Cytokine Responses ◽  
Macrophage Cytokine

scholarly journals Macrophage cytokine responses to commensal Gram-positive Lactobacillus salivarius strains are TLR2-independent and Myd88-dependent

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sreeram Udayan ◽  
Ludovica F. Buttó ◽  
Valerio Rossini ◽  
Janaki Velmurugan ◽  
Maria Martinez-Lopez ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Bacterial Species ◽  
Commensal Bacteria ◽  
Host Cells ◽  
Lactobacillus Salivarius ◽  
Gram Positive ◽  
Cytokine Responses ◽  
Tlr2 Ligand ◽  
Different Strains ◽  
Macrophage Cytokine

AbstractThe mechanisms through which cells of the host innate immune system distinguish commensal bacteria from pathogens are currently unclear. Toll-like receptors (TLRs) are a class of pattern recognition receptors (PRRs) expressed by host cells which recognize microbe-associated molecular patterns (MAMPs) common to both commensal and pathogenic bacteria. Of the different TLRs, TLR2/6 recognize bacterial lipopeptides and trigger cytokines responses, especially to Gram-positive and Gram-negative pathogens. We report here that TLR2 is dispensable for triggering macrophage cytokine responses to different strains of the Gram-positive commensal bacterial species Lactobacillus salivarius. The L. salivarius UCC118 strain strongly upregulated expression of the PRRs, Mincle (Clec4e), TLR1 and TLR2 in macrophages while downregulating other TLR pathways. Cytokine responses triggered by L. salivarius UCC118 were predominantly TLR2-independent but MyD88-dependent. However, macrophage cytokine responses triggered by another Gram-positive commensal bacteria, Bifidobacterium breve UCC2003 were predominantly TLR2-dependent. Thus, we report a differential requirement for TLR2-dependency in triggering macrophage cytokine responses to different commensal Gram-positive bacteria. Furthermore, TNF-α responses to the TLR2 ligand FSL-1 and L. salivarius UCC118 were partially Mincle-dependent suggesting that PRR pathways such as Mincle contribute to the recognition of MAMPs on distinct Gram-positive commensal bacteria. Ultimately, integration of signals from these different PRR pathways and other MyD88-dependent pathways may determine immune responses to commensal bacteria at the host-microbe interface.

scholarly journals Genetically distinct Group B Streptococcus strains induce varying macrophage cytokine responses

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222910 ◽  
Author(s):  
Rebecca A. Flaherty ◽  
Elena C. Borges ◽  
Jessica A. Sutton ◽  
David M. Aronoff ◽  
Jennifer A. Gaddy ◽  
...  
Keyword(s):  
Group B Streptococcus ◽  
Distinct Group ◽  
Cytokine Responses ◽  
Group B ◽  
Macrophage Cytokine

scholarly journals MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis

2009 ◽  
Vol 5 (6) ◽  
pp. e1000474 ◽  
Author(s):  
Dawn M. E. Bowdish ◽  
Kaori Sakamoto ◽  
Mi-Jeong Kim ◽  
Mariliis Kroos ◽  
Subhankar Mukhopadhyay ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Trehalose Dimycolate ◽  
Cytokine Responses ◽  
Macrophage Cytokine
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