scholarly journals An improved, scalable synthesis of the selective serotonin 2A receptor agonist 25CN-NBOH

SynOpen ◽  
2021 ◽  
Author(s):  
Emil Marcher-Rørsted ◽  
Jitka Nykodemova ◽  
Jesper Langgaard Kristensen
Keyword(s):  
Receptor Agonist ◽  
Scientific Community ◽  
In Vitro Studies ◽  
Selective Serotonin ◽  
Serotonin 2A Receptor ◽  
Scalable Synthesis ◽  
Serotonin 2A

4-(2-((2-hydroxybenzyl)amino)ethyl)-2,5-dimethoxybenzonitrile (25CN-NBOH) was first reported as a potent and highly selective serotonin 2A receptor (5-HT2AR) agonist in 2014. The compound has since found extensive use as a pharmacological tool in a variety of in vivo and in vitro studies. In the present study, we present an improved and scalable synthesis of 25CN-NBOH making this compound readily available to the scientific community.

Eseroline: A new antinociceptive agent derived from physostigmine with opiate receptor agonist properties. Experimental in vivo and in vitro studies on cats and rodents

1981 ◽  
Vol 25 (2) ◽  
pp. 179-183 ◽  
Author(s):  
Alessandro Bartolini ◽  
Giovanni Renzi ◽  
Alessandro Galli ◽  
Petra Malmberg Aiello ◽  
Rosalia Bartolini
Keyword(s):  
Receptor Agonist ◽  
Opiate Receptor ◽  
In Vitro Studies

25CN‐NBOH: A selective agonist for in vitro and in vivo investigations of the serotonin 2A receptor

ChemMedChem ◽  
2021 ◽  
Author(s):  
Emil Märcher-Rørsted ◽  
Anders A. Jensen ◽  
Jesper Langgaard Kristensen
Keyword(s):  
Serotonin 2A Receptor ◽  
Selective Agonist ◽  
Serotonin 2A

The Venom of the Boomslang (Dispholidus Typus): In Vivo and in Vitro Studies

1969 ◽  
Vol 21 (02) ◽  
pp. 234-244 ◽  
Author(s):  
N Mackay ◽  
J.C Ferguson ◽  
Antonia Bagshawe ◽  
A.T.T Forrester ◽  
G.P Mcnicol
Keyword(s):  
In Vitro Studies

SummaryAn account is given of the effects of boomslang venom in man. Evidence was found of a fibrinolytic state apparently secondary to the coagulant action of the venom. These features rapidly responded to the administration of specific antivenom. In vitro studies, using a homogenate of boomslang parotids, confirmed the coagulant properties of the venom and showed them to be of much greater potency than the proteolytic actions.

Effect of X-irradiation on gene expression of rat liver chemokines: in vivo and in vitro studies

2008 ◽  
Vol 46 (01) ◽  
Author(s):  
F Moriconi ◽  
H Christiansen ◽  
H Christiansen ◽  
N Sheikh ◽  
J Dudas ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Liver ◽  
In Vitro Studies ◽  
X Irradiation

Ciamexon in low-dose streptozotocin induced diabetes mellitus. In vivo and in vitro studies

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S120-S121
Author(s):  
TH. LINN ◽  
H. GERMANN ◽  
B. HERING ◽  
R. BRETZEL ◽  
K. FEDERLIN
Keyword(s):  
Diabetes Mellitus ◽  
Low Dose ◽  
In Vitro Studies ◽  
Streptozotocin Induced Diabetes
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