Langzeitsicherheit von Blutdrucksenkern

2021 ◽  
Vol 25 (09) ◽  
pp. 366-370
Author(s):  
Markus van der Giet
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Beta Blocker ◽  
Converting Enzyme ◽  
Kardiovaskuläre Mortalität

ZUSAMMENFASSUNGEine optimale Blutdruckeinstellung ist essenziell, um langfristig kardiorenovaskuläre Schäden zu verhindern und um die kardiovaskuläre Mortalität der Patienten zu reduzieren. Viele blutdrucksenkende Medikamente wurden in den letzten Jahrzehnten sehr erfolgreich entwickelt. Patienten müssen diese z. T. für viele Jahre einnehmen, daher erwartet man von den Medikamenten eine sehr hohe Langzeitsicherheit. Das bedeutet, dass es auch nach Jahrzehnten nicht zu unangenehmen Folgeschäden wie v. a. Krebserkrankungen kommen darf. Denn es gab immer wieder Hinweise, dass bestimmte Medikamente wie Thiaziddiuretika oder auch ACE-Hemmer (ACE: „angiotensin converting enzyme“) das Wachstum spezifischer Krebserkrankungen ggf. steigern oder auch die Entstehung von Tumoren auslösen können. Dieser Beitrag fasst den aktuellen Stand zu Langzeitsicherheit bzw. -nebenwirkungen der typischen Blutdrucksenker wie ACE-Hemmer, Sartane, Kalziumantagonisten, Beta-Blocker und Diuretika zusammen.

scholarly journals Effect of Cardioselective Beta Blocker on Lisinopril Treated Isolated Rabbit’s Heart

2020 ◽  
Vol 7 (4) ◽  
pp. 186-190
Author(s):  
Hina Abrar ◽  
M. Tariq Aftab ◽  
Hina Yasin ◽  
Kiran Qadeer ◽  
Adeel Arsalan ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Effective Dose ◽  
Beta Blocker ◽  
Enzyme Inhibitor ◽  
Beta Blockers ◽  
Oral Feeding ◽  
Converting Enzyme ◽  
Pharmacodynamic Interaction ◽  
Isolated Hearts ◽  
Selective Blocker

Background: Certain drugs produce unpredictable responses when used in emergency conditions. These variable outcomes may be harmful or beneficial for the patient. Objective: This study has been conducted to evaluate the pharmacodynamic interaction between angiotensin converting enzyme inhibitor and metoprolol, a selective blocker of β1 receptors. Cardioselective beta blockers are commonly used to treat hypertension, arrhythmias and ischemic heart disease. Method: In this study, 20 healthy male rabbits were selected and divided into two groups. Effective dose of Lisinopril (10 mg/kg) was administered orally via oral feeding, for 9 days. By using Langendroff’s technique, the effects of metoprolol were observed in isolated hearts. Result: The data showed that the effective dose of Lisinopril (10 mg/kg daily orally) increases the inotropic and chronotropic effects of metoprolol significantly (p<0.05). Conclusion: Therefore, lisinopril, an inhibitor of angiotensin converting enzyme may increase the response of cardioselective beta blocker metoprolol in isolated rabbit’s heart.

scholarly journals Comparative Effects of Preoperative Angiotensin-converting Enzyme In-hibitor, Statin and Beta-blocker Treatment on Human Internal Mammary Artery Reactivity in Patients with Coronary Artery Disease: A Pilot Study

2013 ◽  
Vol 7 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Selvinaz Dalaklioglu ◽  
Ilhan Golbasi ◽  
Caglar Ogutman
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Beta Blocker ◽  
Bypass Surgery ◽  
Internal Mammary Artery ◽  
Ace Inhibitor ◽  
Control Group ◽  
Maximal Effect ◽  
Converting Enzyme ◽  
Significant Difference ◽  
Internal Mammary

Purpose: We investigated the effect of angiotensin-converting enzyme (ACE)- inhibitor, statin, and beta-blocker usage before coronary bypass surgery (CABG) on vascular reactivity of the internal mammary artery (IMA). Methods: Patients, who underwent elective CABG were evaluated. Samples of IMA obtained from 22 patients were divided into 4 groups in respect of drugs used by patients before bypass surgery (control group, ACE inhibitor + statin group, ACE inhibitor + statin + beta-blocker group, and ACE inhibitor + beta-blocker group). The discarded, distal end section of IMA was carefully removed, and the vasoreactivity of IMA rings was evaluated in vitro using an organ chamber. Smooth muscle contractile function was tested on artery segments exposed to 10-80 mM KCl and norepinephrine. The endothelial function of IMA rings was assessed with acetylcholine (ACh) and bradykinin, while endothelium-independent vasorelaxation was evaluated by sodium nitroprusside (SNP). Results: Both ACh and bradykinin caused concentration-dependent relaxation in endothelium-intact IMA rings. However, the maximal effect produced by endothelium-dependent agents in all treatment groups was more prominent when compared with the control group. There was no significant difference in the endothelium-dependent relaxation response of IMA between ACE inhibitor + statin, ACE inhibitor + beta-blocker and ACE inhibitor + statin + beta-blocker groups. The vasodilatory potency of SNP was similar in all groups. Similarly, contractile response to KCl or norepinephrine was not significantly different between groups. Conclusion: Use of ACE inhibitors and statins before bypass surgery may influence IMA vasoreactivity by improving endothelial control of vascular tone.

Sign in / Sign up

Export Citation Format

Share Document