P-75: Involvement of protein kinases of the insulin signalling pathway in the activation of glycogen synthase and acetyl-CoA carboxylase by liver cell swelling

2009 ◽  
Vol 104 (S 02) ◽  
pp. 140-141
Author(s):  
Ulrike Krause ◽  
Mark H. Rider ◽  
Louis Hue
Keyword(s):  
Protein Kinases ◽  
Liver Cell ◽  
Glycogen Synthase ◽  
Insulin Signalling ◽  
Signalling Pathway ◽  
Cell Swelling ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa ◽  
P 75 ◽  
Insulin Signalling Pathway

scholarly journals Swelling of rat hepatocytes activates acetyl-CoA carboxylase in parallel to glycogen synthase

1991 ◽  
Vol 278 (3) ◽  
pp. 887-890 ◽  
Author(s):  
A Baquet ◽  
L Maisin ◽  
L Hue
Keyword(s):  
Amino Acids ◽  
Glycogen Synthase ◽  
Rat Hepatocytes ◽  
Cell Swelling ◽  
Common Mechanism ◽  
Acetyl Coa Carboxylase ◽  
Acetyl Coa ◽  
Parallel Activation

Incubation of hepatocytes in conditions known to increase their volume, i.e. with amino acids or in hypo-osmotic media, resulted in the parallel activation of glycogen synthase and acetyl-CoA carboxylase. The activation of both enzymes by glutamine was antagonized by the addition of raffinose to prevent cell swelling, or by glucagon and microcystin. The findings are consistent with the involvement of a common mechanism for the activation of the two enzymes.

scholarly journals Grape seed extract supplementation prevents high-fructose diet-induced insulin resistance in rats by improving insulin and adiponectin signalling pathways

2011 ◽  
Vol 106 (8) ◽  
pp. 1173-1181 ◽  
Author(s):  
Aramsri Meeprom ◽  
Weerachat Sompong ◽  
Wannaporn Suwannaphet ◽  
Sirintorn Yibchok-anun ◽  
Sirichai Adisakwattana
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Mrna Expression ◽  
Glycogen Synthase ◽  
Insulin Signalling ◽  
Grape Seed ◽  
Signalling Pathway ◽  
Signalling Pathways ◽  
High Fructose ◽  
Insulin Signalling Pathway

Recent evidence strongly supports the contention that grape seed extract (GSE) improves hyperglycaemia and hyperinsulinaemia in high-fructose-fed rats. To explore the underlying molecular mechanisms of action, we examined the effects of GSE on the expression of muscle proteins related to the insulin signalling pathway and of mRNA for genes involved in the adiponectin signalling pathway. Compared with rats fed on a normal diet, high-fructose-fed rats developed pathological changes, including insulin resistance, hyperinsulinaemia, hypertriacylglycerolaemia, a low level of plasma adiponectin and a high level of plasma fructosamine. These disorders were effectively attenuated in high-fructose-fed rats supplemented with GSE. A high-fructose diet causes insulin resistance by significantly reducing the protein expression of insulin receptor, insulin receptor substrate-1, Akt and GLUT4, and the mRNA expression of adiponectin, adiponectin receptor R1 (AdipoR1) and AMP-activated protein kinase (AMPK)-α in the skeletal muscle. Supplementation of GSE enhanced the expression of insulin signalling pathway-related proteins, including Akt and GLUT4. GSE also increased the mRNA expression of adiponectin, AdipoR1 and AMPK-α. In addition, GSE increased the mRNA levels of glycogen synthase and suppressed the mRNA expression of glycogen synthase kinase-3-α, causing an increase in glycogen accumulation in the skeletal muscle. These results suggest that GSE ameliorates the defective insulin and adiponectin signalling pathways in the skeletal muscle, resulting in improved insulin resistance in fructose-fed rats.

scholarly journals The insulin signalling pathway

2002 ◽  
Vol 12 (7) ◽  
pp. R236-R238 ◽  
Author(s):  
Jose M. Lizcano ◽  
Dario R. Alessi
Keyword(s):  
Insulin Signalling ◽  
Signalling Pathway ◽  
Insulin Signalling Pathway

Effect of food restriction on the insulin signalling pathway in rat skeletal muscle and adipose tissue

2005 ◽  
Vol 16 (10) ◽  
pp. 602-609 ◽  
Author(s):  
Ana Alonso ◽  
Yolanda Fernández ◽  
Rebeca Fernández ◽  
Patricia Ordóñez ◽  
María Moreno ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Food Restriction ◽  
Insulin Signalling ◽  
Signalling Pathway ◽  
Rat Skeletal Muscle ◽  
Insulin Signalling Pathway ◽  
Effect Of Food

scholarly journals Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Simin Tian ◽  
Min Wang ◽  
Chenyue Liu ◽  
Hongbin Zhao ◽  
Baosheng Zhao
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Insulin Signalling ◽  
Signalling Pathway ◽  
Inflammatory Factor ◽  
Diabetic Mice ◽  
Mulberry Leaf ◽  
Insulin Signalling Pathway ◽  
Tnf Α ◽  
Necrosis Factor

Abstract Background It has been testified that Diabetes mellitus (DM) has a close association with chronic inflammation and Toll-like Receptors (TLRs), and DM could be prevented by mulberry leaf. Therefore, a hypothesis came into being that mulberry leaf could ameliorate proinflammation and insulin resistance (IR) through TLRs and insulin signalling pathways. Methods Water extracts of mulberry leaf (WEM) was given to diabetic mice by gavage for 10 weeks, and the diabetic mice was injected with low-dose streptozocin, fed with high-fat and high-sugar diet. Oral glucose tolerance tests (OGTTs) were conducted. At the same time, homeostasis model assessment of insulin (HOMA-IR) and the level of the inflammatory factor, tumour necrosis factor-α (TNF-α) was measured. The expressions of critical nodes of TLRs and insulin signalling pathway were also examined. Results WEM contributed to a significant decrease in fasting blood glucose, AUC from the investigation of OGTTs and HOMA-IR. The levels of the inflammatory factor, tumour necrosis factor-α (TNF-α) also declined. Moreover, WEM suppressed the expression of TLR2, myeloid differentiation primary-response protein 88 (MyD88), tumour-necrosis-factor receptor-associated factor 6 (TRAF6), nuclear factor kappa B (NF-κB) in the skeletal muscle. WEM could up-regulate the expression of insulin receptor (InsR) and insulin receptor substrate 1 (IRS1), and down-regulate the phosphorylation of IRS1 in adipose tissue. Conclusion Through this study, a conclusion could be made that WEM mitigates hyperglycemia, IR, and inflammation through the interactions among TLR2 signalling pathway, insulin signalling pathway and TNF-α.

scholarly journals S-resistin, a non secretable resistin isoform, impairs the insulin signalling pathway in 3T3-L1 adipocytes

2015 ◽  
Vol 71 (3) ◽  
pp. 381-390 ◽  
Author(s):  
María Rodríguez ◽  
Eduardo Moltó ◽  
Lidia Aguado ◽  
Nilda Gallardo ◽  
Antonio Andrés ◽  
...  
Keyword(s):  
Insulin Signalling ◽  
Signalling Pathway ◽  
Insulin Signalling Pathway
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