Are food and nicotine craving mediated by the same transmitter related drug and respective hormone responses?

2009 ◽  
Vol 42 (05) ◽  
Author(s):  
P Netter ◽  
C Toll ◽  
A Siegmund ◽  
T Birkenbach-Holdschuh ◽  
C Lujic
Keyword(s):  
Related Drug ◽  
Hormone Responses

Linear Arrays of Helical Polyribosomes in Cells Exposed to Antitumor Drug Vincristine Sulfate

1969 ◽  
Vol 27 ◽  
pp. 358-359
Author(s):  
Awtar Krishan
Keyword(s):  
Close Association ◽  
Annulate Lamellae ◽  
Large Array ◽  
Vincristine Sulfate ◽  
Linear Arrays ◽  
Golgi Membranes ◽  
Related Drug ◽  
Drug Leads ◽  
Lethal Doses ◽  
Vinblastine Sulfate

Earle's L-929 fibroblasts treated with mitosis-arresting but sub-lethal doses of vinblastine sulfate (VLB) show hypertrophy of the granular endoplasmic reticulum and annulate lamellae. Exposure of the cells to heavier doses of vincristine sulfate (VCR), a VLB-related drug, leads to the accumulation of large amounts of helical polyribosomes, Golgi membranes and crystals in the cytoplasm. In many of these cells a large number of helical polyribosomes are arranged in prominent linear rows, some of which may be up to 5 micrometers in length. Figure 1 shows a large array of helical polyribosomes near a crystalline mass (CRS) in an Earle's L-929 fibroblast exposed to VCR (5ϒ/ml.) for 3 hours At a higher magnification, as seen in figure 2, the helical polyribosomes are seen arranged in parallel rows. In favorably cut sections, a prominent backbone like "stalk" of finely granular material, measuring approximately 300Å in width is seen in close association with the linear rows of helical polyribosomes.

Methods to unravel the role of HDAC10 in autophagy-related drug resistance

2015 ◽  
Vol 227 (06/07) ◽  
Author(s):  
J Fabian ◽  
J Ridinger ◽  
O Witt ◽  
I Oehme
Keyword(s):  
Drug Resistance ◽  
Related Drug

GROWTH HORMONE RESPONSES TO FRUCTOSE IN DIABETES MELLITUS

1974 ◽  
Vol 75 (3) ◽  
pp. 497-502
Author(s):  
Mayer B. Davidson ◽  
Roger M. Steele
Keyword(s):  
Diabetes Mellitus ◽  
Growth Hormone ◽  
Fasting Glucose ◽  
Area Under The Curve ◽  
Oral Glucose ◽  
Gh Secretion ◽  
Significant Difference ◽  
Duration Of Disease ◽  
Hormone Responses

ABSTRACT Since fructose is normally metabolized in diabetics and has recently been shown to stimulate GH secretion, it was used to assess GH responses in diabetics. Fourteen diabetics (9 on insulin) and 8 controls matched for weight were studied. Fructose, infused over 10 min, was compared to arginine, infused over 30 min, both at 0.5 g/kg. Samples were collected at 0, 30, 60, 90 and 120 min and GH responses assessed as area under the curve minus the fasting area. There was no significant difference between the GH responses in diabetics and controls to either agent. Responses to arginine and fructose were significantly correlated (r = 0.60, P < 0.01) in all subjects, but not related to therapy, duration of disease or fasting glucose (75–287 mg/100 ml) in the diabetics. Oral glucose blunted the GH response to fructose in 2 controls. It is concluded that 1) fructose can stimulate GH secretion in male diabetics; 2) however, fructose-stimulated GH responses are not increased in diabetes mellitus.

Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans

Diabetes ◽  
1987 ◽  
Vol 36 (4) ◽  
pp. 518-522 ◽  
Author(s):  
S. A. Amiel ◽  
D. C. Simonson ◽  
W. V. Tamborlane ◽  
R. A. DeFronzo ◽  
R. S. Sherwin
Keyword(s):  
Hormone Responses

scholarly journals Approaches for Mitigating Microbial Biofilm-Related Drug Resistance: A Focus on Micro- and Nanotechnologies

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1870
Author(s):  
Harinash Rao ◽  
Sulin Choo ◽  
Sri Raja Rajeswari Mahalingam ◽  
Diajeng Sekar Adisuri ◽  
Priya Madhavan ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Physiological State ◽  
Persister Cells ◽  
Microbial Biofilm ◽  
Antimicrobial Coatings ◽  
Drug Efflux Pumps ◽  
Lock Therapy ◽  
Related Drug ◽  
Healthcare Associated ◽  
Potential Therapeutics

Biofilms play an essential role in chronic and healthcare-associated infections and are more resistant to antimicrobials compared to their planktonic counterparts due to their (1) physiological state, (2) cell density, (3) quorum sensing abilities, (4) presence of extracellular matrix, (5) upregulation of drug efflux pumps, (6) point mutation and overexpression of resistance genes, and (7) presence of persister cells. The genes involved and their implications in antimicrobial resistance are well defined for bacterial biofilms but are understudied in fungal biofilms. Potential therapeutics for biofilm mitigation that have been reported include (1) antimicrobial photodynamic therapy, (2) antimicrobial lock therapy, (3) antimicrobial peptides, (4) electrical methods, and (5) antimicrobial coatings. These approaches exhibit promising characteristics for addressing the impending crisis of antimicrobial resistance (AMR). Recently, advances in the micro- and nanotechnology field have propelled the development of novel biomaterials and approaches to combat biofilms either independently, in combination or as antimicrobial delivery systems. In this review, we will summarize the general principles of clinically important microbial biofilm formation with a focus on fungal biofilms. We will delve into the details of some novel micro- and nanotechnology approaches that have been developed to combat biofilms and the possibility of utilizing them in a clinical setting.

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