Spot Scanning Based Proton Therapy for Skull Base Meningiomas: Long-Term Results from the Paul Scherrer Institute

2012 ◽  
Vol 73 (S 02) ◽  
Author(s):  
D. Weber ◽  
R. Schneider ◽  
T. Koch ◽  
J. Geismar ◽  
A. Schertler ◽  
...  
Keyword(s):  
Skull Base ◽  
Proton Therapy ◽  
Paul Scherrer Institute ◽  
Long Term Results ◽  
Spot Scanning ◽  
Skull Base Meningiomas ◽  
Paul Scherrer

scholarly journals Long-term outcomes and prognostic factors of skull-base chondrosarcoma patients treated with pencil-beam scanning proton therapy at the Paul Scherrer Institute

2015 ◽  
Vol 18 (2) ◽  
pp. 236-243 ◽  
Author(s):  
Damien C. Weber ◽  
Shahed Badiyan ◽  
Robert Malyapa ◽  
Francesca Albertini ◽  
Alessandra Bolsi ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Skull Base ◽  
Proton Therapy ◽  
Paul Scherrer Institute ◽  
Pencil Beam ◽  
Long Term Outcomes ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Paul Scherrer

High Efficacy of Fractionated Stereotactic Radiotherapy of Large Base-of-Skull Meningiomas: Long-Term Results

2001 ◽  
Vol 19 (15) ◽  
pp. 3547-3553 ◽  
Author(s):  
Juergen Debus ◽  
Martina Wuendrich ◽  
Andrea Pirzkall ◽  
Angelika Hoess ◽  
Wolfgang Schlegel ◽  
...  
Keyword(s):  
Skull Base ◽  
Stereotactic Radiotherapy ◽  
Fractionated Stereotactic Radiotherapy ◽  
World Health ◽  
Long Term Results ◽  
Subtotal Resection ◽  
Who Grade ◽  
Skull Base Meningiomas

PURPOSE: Large skull-base meningiomas are difficult to treat due to their proximity or adherence to critical structures. We analyzed the long-term results of patients with skull-base meningiomas treated by a new approach with high-precision fractionated stereotactic radiotherapy. PATIENTS AND METHODS: One hundred eighty-nine patients with benign meningiomas were treated with conformal fractionated stereotactic radiotherapy between 1985 and 1998. Patients were undergoing a course of radiotherapy either as primary treatment, following subtotal resection, or for recurrent disease. The median target volume was 52.5 mL (range, 5.2 to 370 mL). The mean radiation dose was 56.8 Gy (± 4.4 Gy). Follow-up examinations, including magnetic resonance imaging, were performed at 6-month intervals thereafter. RESULTS: The median follow-up period was 35 months (range, 3 months to 12 years). Overall actuarial survival for patients with World Health Organization (WHO) grade I meningiomas was 97% after 5 years and 96% after 10 years. Local tumor failure was observed in three of 180 patients with WHO grade I tumors and was significantly higher in two of nine patients with WHO grade II tumors. A volume reduction of more than 50% was observed in 26 patients (14%). Preexisting cranial nerve symptoms resolved completely in 28% of the patients. Clinically significant treatment-induced toxicity was seen in 1.6% of the patients. No treatment-related deaths occurred. CONCLUSION: The results of this study demonstrate that fractionated stereotactic radiotherapy is safe and effective in the therapy of subtotally resected or unresectable meningiomas. The overall morbidity and incidence subacute and late side effects of this conformal radiotherapy approach were low.

scholarly journals PC3 - 141 Long-Term Results of Stereotactic Radiosurgery for Skull Base Meningiomas

2016 ◽  
Vol 43 (S4) ◽  
pp. S21-S21
Author(s):  
O. Cohen-Inbar
Keyword(s):  
Tumor Progression ◽  
Skull Base ◽  
Clinical Improvement ◽  
Tumor Volume ◽  
Long Term Results ◽  
Tumor Control ◽  
Long Term Outcome ◽  
Skull Base Meningiomas

Gamma knife radiosurgery (GKRS) is well-established in the management of inaccessible, recurrent, or residual benign skull base meningiomas. Most series report clinical outcome parameters and complications in the short -intermediate period after radiosurgery. Reports of long-term tumor control and neurological status are still lacking. Objective: We report the presentation, treatment, and long-term outcome of skull base meningiomas after GKRS. Methods: From a prospectively collected IRB approved database, we selected patients with a WHO grade I skull base meningioma treated with a single-session GKRS and a minimum of 60 months follow up. 135 patients, 54.1% males (n=73) form the cohort. Median age was 54 years (19-80). Median tumor volume was 4.7 cm3 (0.5-23). Median margin dose was 15 Gy (7.5-36). Median follow up was 102.5 months (60.1-235.4). Patient and tumor characteristics were assessed to determine predictors of neurological function and tumor progression. Results: At last follow up, tumor volume control was achieved in 88.1% (n=119). Post-GKRS clinical improvement or stability was reported in 61.5%. The 5, 10, and 15 years actuarial progression free survival rates are 100%, 95.4%, and 68.8%, respectively. Favorable outcome (both tumor control and clinical preservation/improvement) was attained in 60.8% (n=79). Pre-GKRS performance status (KPS) was shown to influence tumor progression (p=0.0001) and post-GKRS clinical improvement / preservation (p=0.003). Conclusion: GKRS offers a highly durable rate of tumor control for WHO-I skull base meningiomas, with an acceptably low incidence of neurological deficits. KPS at the time of radiosurgery serves as a reliable long-term predictor of overall outcome.

scholarly journals OP18LONG TERM OUTCOMES OF SKULL-BASE LOW-GRADE CHONDROSARCOMA PATIENTS TREATED WITH PENCIL BEAM SCANNING PROTON THERAPY AT THE PAUL SCHERRER INSTITUTE

2015 ◽  
Vol 17 (suppl 8) ◽  
pp. viii3.4-viii3 ◽  
Author(s):  
Damien Charles Weber ◽  
Shahed Badiyan ◽  
Tony Lomax ◽  
Robert Malyapa ◽  
Alessandra Bolsi ◽  
...  
Keyword(s):  
Skull Base ◽  
Proton Therapy ◽  
Paul Scherrer Institute ◽  
Low Grade ◽  
Pencil Beam ◽  
Beam Scanning ◽  
Pencil Beam Scanning ◽  
Paul Scherrer
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