Thoracic Endodermal Sinus Tumor with Root Compression Mimicking Guillain–Barre Syndrome in Clinical Presentation, CSF Studies, and EMG/NCV Findings

2019 ◽  
Vol 18 (04) ◽  
pp. 195-197
Author(s):  
Gal Barbut ◽  
Yuri Brosgol ◽  
Mahmut Celiker ◽  
Evan G. Stein ◽  
Gary N. McAbee

AbstractA 2-year-old boy who presented with clinical, cerebrospinal fluid, and electrophysiological findings consistent with Guillain–Barre syndrome (GBS) was found to have a thoracic spinal cord mass due to a yolk sac tumor. On examination, he had an absent anal wink and flaccid anal ring which is atypical for GBS. This case demonstrates the need for a thorough physical examination on presentation of a child with a clinical and laboratory presentation of GBS and highlights the importance of prompt imaging studies when clinical suspicion arises because of atypical clinical signs, such as absent anal wink or low rectal tone.

2009 ◽  
Vol 56 (3) ◽  
pp. 270-270
Author(s):  
James Scozzafava ◽  
Glen Jickling ◽  
Jack H. Jhamandas ◽  
Michael J. Jacka

2008 ◽  
Vol 55 (7) ◽  
pp. 441-446 ◽  
Author(s):  
James Scozzafava ◽  
Glen Jicking ◽  
Jack H. Jhamandas ◽  
Michael J. Jacka

2021 ◽  
Vol 2021 (9) ◽  
Author(s):  
Celeste Camargo ◽  
Tathagat Narula ◽  
Daniel A Jackson ◽  
Teresa Padro ◽  
W David Freeman

ABSTRACT Guillain-Barré syndrome (GBS) is an immune-mediated polyneuropathy, which is characterized by areflexia and ascending paresthesia which can progress to a respiratory failure. Certain conditions, such as vasculitis and heavy metal and drug toxicity, may have misleadingly similar clinical presentation to GBS. We describe a case of a patient with cystic fibrosis and intravenous colistin-induced neurotoxicity mimicking GBS. The patient had used inhaled colistin on five occasions with no adverse effects, however, developed symptoms on the second day of intravenous treatment. Overlapping findings between immune-mediated polyneuropathy and drug-induced neurotoxicity include limb paresthesia and decreased reflexes. Perioral tingling, however, is a common presentation of colistin-induced neurotoxicity, and therefore, is an important differentiating factor. Early diagnosis prevents further neurologic decline, extensive unnecessary workup and potentially harmful incorrect management.


2021 ◽  
Author(s):  
Yasmim Nadime José Frigo ◽  
Hendrick Henrique Fernandes Gramasco ◽  
Ana Flavia Andrade ◽  
Guilherme Drumond Jardini Anastácio ◽  
Stella de Angelis Trivellato ◽  
...  

Introduction: Guillain-Barré syndrome is an acute / subacute inflammatory polyradiculoneuropathy that classically results in flaccid areflex palsy. However, there are other possibilities of clinical presentation that must be remembered so that an adequate diagnosis and treatment is carried out. Case report: Female patient, 23 years old, without comorbidities, with complaint of paresthesia in extremities and right peripheral facial paralysis, having diagnosis until then of Bell’s Palsy. She denied previous or current infectious complaints. The neurological examination revealed facial diparesis, proximal weakness of the lower limbs that made walking difficult, tactile and painful hypoesthesia in the feet, with reflexes 1+/4+ in the lower limbs and 3+/4+ in the upper limbs. An investigation was started with CSF collection that showed albuminocytological dissociation (proteins 440 mg/dl and leukocytes 01 mm3). Neuroimaging exams showed contrast impregnation in facial and trigeminal nerves. A diagnosis of acute inflammatory polyradiculoneuropathy was made and treatment with human immunoglobulin was initiated for 5 days. Electroneuromyography showed peripheral, sensory-motor polyradiculoneuropathy and questioned the physiopathological possibility of juxtaparanodopathy. The patient presented a significant and early improvement after treatment. Conclusions: It is essential to consider that Guillain-Barré syndrome has symptom variability, especially according to its pathophysiology and clinical and electrophysiological variant, thus avoiding that conditions such as this one are underdiagnosed.


2011 ◽  
Vol 123 (3) ◽  
pp. 181-186 ◽  
Author(s):  
A. Soysal ◽  
F. Aysal ◽  
B. Calıskan ◽  
P. Dogan Ak ◽  
B. Mutluay ◽  
...  

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