P53 regulates the lipid metabolism response to metabolic stress in brown adipose tissue

2020 ◽  
Author(s):  
G Lenihan-Geels ◽  
F Garcia-Carrizo ◽  
C Li ◽  
M Oster ◽  
A Prokesch ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Brown Adipose Tissue ◽  
Metabolic Stress ◽  
Brown Adipose

scholarly journals Identification of functional lipid metabolism biomarkers of brown adipose tissue aging

2019 ◽  
Vol 24 ◽  
pp. 1-17 ◽  
Author(s):  
Sabrina Gohlke ◽  
Vyacheslav Zagoriy ◽  
Alvaro Cuadros Inostroza ◽  
Michaël Méret ◽  
Carola Mancini ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Brown Adipose Tissue ◽  
Brown Adipose ◽  
Tissue Aging

scholarly journals Brown adipose tissue and lipid metabolism imaging

Methods ◽  
2017 ◽  
Vol 130 ◽  
pp. 105-113 ◽  
Author(s):  
Andreas Paulus ◽  
Wouter van Marken Lichtenbelt ◽  
Felix M. Mottaghy ◽  
Matthias Bauwens
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Brown Adipose Tissue ◽  
Brown Adipose

scholarly journals The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Xiaoliang Shao ◽  
Wei Yang ◽  
Xiaonan Shao ◽  
Chun Qiu ◽  
Xiaosong Wang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Brown Adipose Tissue ◽  
Chinese Adults ◽  
Brown Adipose ◽  
Healthy Chinese

scholarly journals Catalase deficiency facilitates the shuttling of free fatty acid to brown adipose tissue through lipolysis mediated by ROS during sustained fasting

2021 ◽  
Author(s):  
Raghbendra Kumar Dutta ◽  
Joon No Lee ◽  
Yunash Maharjan ◽  
Channy Park ◽  
Seong-Kyu Choe ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Brown Adipose Tissue ◽  
Energy Homeostasis ◽  
Redox Homeostasis ◽  
Ros Generation ◽  
Peroxisomal Enzyme ◽  
Triglyceride Accumulation ◽  
Brown Adipose

Abstract Background Fatty acids (FA) derived from adipose tissue and liver serve as the main fuel in thermogenesis of brown adipose tissue (BAT). Catalase, a peroxisomal enzyme, plays an important role in maintaining intracellular redox homeostasis by decomposing hydrogen peroxide to either water or oxygen that oxidize and provide fuel for cellular metabolism. Although the antioxidant enzymatic activity of catalase is well known, its role in the metabolism and maintenance of energy homeostasis has not yet been revealed. The present study investigated the role of catalase in lipid metabolism and thermogenesis during nutrient deprivation in catalase-knockout (KO) mice. Results We found that hepatic triglyceride accumulation in KO mice decreased during sustained fasting due to lipolysis through reactive oxygen species (ROS) generation in adipocytes. Furthermore, the free FA released from lipolysis were shuttled to BAT through the activation of CD36 and catabolized by lipoprotein lipase in KO mice during sustained fasting. Although the exact mechanism for the activation of the FA receptor enzyme is still unclear, we found that ROS generation in adipocytes mediated the shuttling of FA to BAT. Conclusions Taken together, our findings uncover the novel role of catalase in lipid metabolism and thermogenesis in BAT, which may be useful in understanding metabolic dysfunction.

scholarly journals The functional role of brown adipose tissue in whole‐body lipid metabolism in humans (1160.3)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Maria Chondronikola ◽  
Craig Porter ◽  
Nicholas Hurren ◽  
Tony Chao ◽  
Christina Yfanti ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Brown Adipose Tissue ◽  
Functional Role ◽  
Whole Body ◽  
Body Lipid ◽  
Brown Adipose

Brown adipose tissue lipid metabolism in morbid obesity: Effect of bariatric surgery‐induced weight loss

2018 ◽  
Vol 20 (5) ◽  
pp. 1280-1288 ◽  
Author(s):  
Prince Dadson ◽  
Jarna C. Hannukainen ◽  
Mueez U Din ◽  
Minna Lahesmaa ◽  
Kari K. Kalliokoski ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Brown Adipose Tissue ◽  
Tissue Lipid ◽  
Brown Adipose

Autocrine effects of transgenic resistin on brown adipose tissue glucose and lipid metabolism

2017 ◽  
Vol 263 ◽  
pp. e71
Author(s):  
Jaroslava Trnovská ◽  
Michal Pravenec ◽  
Jan Silhavy ◽  
Hynek Strnad ◽  
Sebastian Eigner ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Brown Adipose Tissue ◽  
Glucose And Lipid Metabolism ◽  
Brown Adipose
Sign in / Sign up

Export Citation Format

Share Document